Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan

Cell Systems - Tập 2 - Trang 122-132 - 2016
Mario Baumgart1, Steffen Priebe2, Marco Groth1, Nils Hartmann1, Uwe Menzel2, Luca Pandolfini3, Philipp Koch1, Marius Felder1, Michael Ristow4, Christoph Englert1,5, Reinhard Guthke2, Matthias Platzer1, Alessandro Cellerino1,3
1Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany
2Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Beutenbergstraße 11a, 07745 Jena, Germany
3Scuola Normale Superiore, Laboratory of Biology, c/o Istituto di Biofisica del CNR, via Moruzzi 1, 56124 Pisa, Italy
4Energy Metabolism Laboratory, ETH Zürich (Swiss Federal Institute of Technology), Schorenstrasse 16, 8603 Schwerzenbach-Zürich, Switzerland
5Faculty of Biology and Pharmacy, Friedrich Schiller University Jena, 07743 Jena, Germany

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