Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

Molecular Cell - Tập 59 - Trang 285-297 - 2015
Daniel F. Egan1, Matthew G.H. Chun1, Mitchell Vamos2, Haixia Zou2, Juan Rong2, Chad J. Miller3, Hua Jane Lou3, Dhanya Raveendra-Panickar2, Chih-Cheng Yang4, Douglas J. Sheffler2, Peter Teriete2, John M. Asara5,6, Benjamin E. Turk3, Nicholas D.P. Cosford2, Reuben J. Shaw1,7
1Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
2Cell Death and Survival Networks Research Program, NCI-Designated Cancer Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
3Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520 USA
4Functional Genomics Core, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
5Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115 USA
6Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
7Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA

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