Patient, caregiver, health professional and researcher views and experiences of participating in research at the end of life: a critical interpretive synthesis of the literature

BMC Medical Research Methodology - Tập 12 Số 1 - 2012
Marjolein Gysels1, Catherine Evans1, Irene J Higginson1
1King's College London, Cicely Saunders Institute, Department of Palliative Care, Policy and Rehabilitation, School of Medicine, London, UK.

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Tài liệu tham khảo

National Institute on Aging: Why population aging matters: a global perspective. 2007, US Department of Health and Human Services, US Department of State: National Institutes of Health

World Health Organization: The global burden of disease. 2008

A Report from the Economist Intelligence Unit: The quality of death. 2010, London: Ranking end-of-life care across the world

Casarett D: Ethical considerations in end-of-life care and research. Journal of Palliative Medicine. 2005, 8: S148-S160. 10.1089/jpm.2005.8.148.

Jubb AM: Palliative care research: trading ethics for an evidence base. Journal of Medical Ethics. 2002, 28: 342-346. 10.1136/jme.28.6.342.

Kaasa S, Dale O: Pain and Palliation Research G: Building up research in palliative care: a historical perspective and a case for the future. Clinical Geriatric Medicine. 2005, 21: 81-92. 10.1016/j.cger.2004.08.009.

Riley J, Ross JR: Research into care at the end of life. Lancet. 2005, 365: 735-737.

Beaver K, Luker K, Woods S: Conducting research with the terminally ill: challenges and considerations. Int J Palliat Nurs. 1999, 5: 13-17.

Grande CE, Todd CJ: Why are trials in palliative care so difficult?. Palliative Medicine. 2000, 14: 69-74. 10.1191/026921600677940614.

Rinck GC, van den Bos GA, Kleijnen J, de Haes HJ, Schade E, Veenhof CH: Methodologic issues in effectiveness research on palliative cancer care: a systematic review. J Clin Oncol. 1997, 15: 1697-1707.

Duke S, Bennet H: A narrative review of the published ethical debates in palliative care research and an assessment of their adequacy to inform research governance. Palliative Medicine. 2010, 24: 111-126. 10.1177/0269216309352714.

Todd AM, Laird BJ, Boyle D, Boyd AC, Colvin LA, Fallon MT: A systematic review examining the literature on attitudes of patients with advanced cancer toward research. Journal of Pain and Symptom Management. 2009, 37: 1078-1085. 10.1016/j.jpainsymman.2008.07.009.

White C, Hardy J: What do palliative care patients and their relatives think about research in palliative care? - a systematic review. Supportive Care in Cancer. 2009, 18: 905-911.

Dixon-Woods M, Cavers D, Agarwal S, Annandale E, Arthur E, Harvey J, et al: Conducting a critical interpretive synthesis of the literature on access to health care by vulnerable groups. BMC Medical Research Methodology. 2006, 6: 35-10.1186/1471-2288-6-35.

Kirsh KL, Walker R, Snider S, Weisenfluh S, Brown GM, Passik SD: Hospice staff members' views on conducting end-of-life research. Palliative & Supportive Care. 2004, 2: 273-282.

Casarett DJ, Karlawish J, Hirschman KB: Are Hospices Ready to Participate in Palliative Care Research? Results of a National Survey. Journal of Palliative Medicine. 2002, 5 (3): 397-406. 10.1089/109662102320135289.

White CD, Hardy JR, Gilshenan KS, Charles MA, Pinkerton CR: Randomised controlled trials of palliative care - a survey of the views of advanced cancer patients and their relatives. European Journal of Cancer Care. 1828, 2008: 44-

Williams C, Shuster J, Clay O, Burgio K: Interest in Research Participation among Hospice Patients, Caregivers, and Ambulatory Senior Citizens: Practical Barriers or Ethical Contraints?. Journal of Palliative Medicine. 2006, 9: 968-974. 10.1089/jpm.2006.9.968.

Terry W, Olson LG, Ravenscroft P, Wilss L, Boulton-Lewis G: Hospice patients' views on research in palliative care. Internal Medicine Journal. 2006, 36: 406-413. 10.1111/j.1445-5994.2006.01078.x.

Shipman C, Hotoph M, Richardson A, Murray S, Koffman J, Harding R, et al: The views of patients with advanced cancer regarding participation in serial questionnaire studies. Palliative Medicine. 2008, 213: 913-920.

Christ GH, Siegel K, Weinstein L: Developing a research unit within a hospital social work department. Heal Soc Work. 1995, 20: 60-69.

Daly BJ, Douglas SL, Foley H, Lipson A, Liou CF, Bowman K, et al: Psychosocial registry for persons with cancer: a method of facilitating quality of life and symptom research. Psycho-Oncology. 2007, 16: 358-364. 10.1002/pon.1091.

Barnett M: Interviewing terminally ill people: Is it fair to take their time?. Palliative Medicine. 2001, 15 (2): 157-158. 10.1191/026921601666846232.

Davies EA, Hall SM, Clarke CR, Bannon MP, Hopkins AP: Do research interviews cause distress or interfere in management? Experience from a study of cancer patients. Journal of the Royal College of Physicians of London. 1998, 32: 406-411.

Dobratz MC: Issues and dilemmas in conducting research with vulnerable home hospice participants. J Nurs Scholarsh. 2003, 35: 371-376. 10.1111/j.1547-5069.2003.00371.x.

Emanuel EJ, Fairclough DL, Wolfe P, Emanuel LL: Talking with terminally ill patients and their caregivers about death, dying, and breavement: is it stressful, is it helpful?. Arch Intern Med. 2004, 164: 1999-2004. 10.1001/archinte.164.18.1999.

Gysels M, Shipman C, Higginson IJ: "I will do it if it helps others": motivations and distress among patients taking part in qualitative studies on palliative care. Palliative Medicine. 2006, 20: 255-

Kendall M, Harris F, Boyd K, Sheikh A, Murray SA, Brown D, et al: Key challenges and ways forward in researching the "good death": qualitative in-depth interview and focus group study. British Medical Journal. 2007, 334: 521-10.1136/bmj.39097.582639.55.

Pessin H, Galietta M, Nelson CJ, Brescia R, Rosenfeld B, Breitbart W: Burden and benefit of psychosocial research at the end of life. Journal of Palliative Medicine. 2008, 11 (4): 627-632. 10.1089/jpm.2007.9923.

Phipps E, Harris D, Braitman LE, Tester W, Thompson N, True G: Who Enrolls in Observational End of Life Research? Report from the Cultural Variations in Approaches to End of Life Study. Journal of Palliative Medicine. 2005, 8: 115-120. 10.1089/jpm.2005.8.115.

Takesaka J, Crowley R, Cassarett D: What is the risk of distress in palliative care survey research?. Journal of Pain & Symptom Management. 2004, 28: 593-598. 10.1016/j.jpainsymman.2004.03.006.

Wright DNM, Hopkinson JB, Corner JL, Foster CL: How to involve cancer patients at the end of life as co-researchers. Palliative Medicine. 2006, 20: 821-827. 10.1177/0269216306073110.

Wright K, Flemons D: Dying to know: Qualitative research with terminally ill persons and their families. Death Studies. 2002, 26: 255-271. 10.1080/07481180211268.

Grbich C, Abernethy AP, Shelby-James T, Fazekas B, Currow DC: Creating a research culture in a palliative care service environment: a qualitative study of the evolution of staff attitudes to research during a large longitudinal controlled trial. Journal of Palliative Care. 2008, 24: 100-109.

Henderson M, Addington-Hall JM, Hotopf M: The willingness of palliative care patients to participate in research. Journal of Pain & Symptom Management. 2005, 29: 116-118. 10.1016/j.jpainsymman.2004.12.001.

Fallowfied L, Jenkins V, Brennan C, Sawtell M, Moynihan C, Souhami R: Attitudes of patients to randomised clinical trials of cancer therapy. European Journal of Cancer Care. 1989, 34: 1554-1559.

Fallowfield L, Ratcliffe D, Souhami R: Clinicians attitudes to clinical trials of cancer therapy. European Journal of Cancer Care. 1997, 33: 2221-2229.

Tolley DC, Payne R: Hospice Partnerships with Academic Entities: Philosophical and Historical Background and Assessment of Future Needs. Journal of Pain and Symptom Management. 2007, 33: 90-98. 10.1016/j.jpainsymman.2006.10.007.

Seymour J, Payne S, Reid D, Sargeant A, Skilbeck J, Smith P: Ethical and methodological issues in palliative care studies: The experiences of a research group. NT Res. 2005, 21: 169-188.

Koenig BA, Back AL, Crawley LM: Qualitative methods in end-of-life research: recommendations to enhance the protection of human subjects. Journal of Pain & Symptom Management. 2003, 25: S43-S52. 10.1016/S0885-3924(03)00060-5.

Larkin PJ, de Casterle BD, Schotsmans P: A relational ethical dialogue with research ethics committees. Nursing Ethics. 2008, 19: 234-242.

Fine PG: Maximising benefits and minimising risks in palliative care research that involves patients near the end of life. Journal of Pain & Symptom Management. 2003, 25: S53-S62. 10.1016/S0885-3924(03)00056-3.

Jenkins V, Leach L, Fallowfield L, Nicholls K, Newsham A: Describing randomisation: patients' and the public's preferences compared with clinicians' practice. Br J Cancer. 2002, 87: 854-858. 10.1038/sj.bjc.6600527.