Effect of Antibodies to Glutamate on Retention of Conditioned Passive Avoidance Response in Rats with Ischemic Injury of the Prefrontal Cortex
Tóm tắt
Experiments were performed on rats with bilateral photothrombosis of vessels in the prefrontal cortex. Intranasal administration of antibodies to glutamate (1 h after ischemia of the brain cortex) improved retention of conditioned passive avoidance response, which was elicited before ischemic damage. The content of antibodies to glutamate in the serum of rats increased significantly on day 8 after bilateral photochemical thrombosis of vessels in the prefrontal cortex compared to that in the control.
Tài liệu tham khảo
J. Buresh, O. Bureshova, and J. P. Houston, Methods and Main Experiments for Studies of the Brain and Behavior [in Russian], Moscow (1991).
E. I. Gusev and V. I. Skvortsova, Cerebral Ischemia [in Russian], Moscow (2001).
T. V. Davydova, N. I. Voskresenskaya, V. G. Fomina, et al., Byull. Eksp. Biol. Med., 143, No. 2, 140-141 (2007).
T. V. Davydova, N. I. Voskresenskaya, V. G. Fomina, et al., Ibid., 142, No. 12, 624-626 (2006).
V. A. Evseev, Antibodies to Neurotransmitters in the Mechanisms of Neuroimmunopathology [in Russian], Moscow (2007).
G. A. Romanova, I. V. Barskov, R. U. Ostrovskaya, et al., Patol. Fiziol. Eksper. Ter., No. 2, 8-10 (1998).
G. A. Romanova, Dysregulation Pathology, Ed. G. N. Kryzhanovskii [in Russian], Moscow (2002), pp. 605-615.
The Rat Brain in Stereotaxic Coordinates. 3rd Edition, G. Paxinos and C. Watson, San Diego (1997).
P. Seguela, M. Geffard, R. Buijs, and M. Le Moal, Proc. Natl. Acad. Sci. USA, 81, No. 12, 3888-3892 (1984).
S. Talegaonkar and P. R. Mishra, Indian J. Pharmacol., 36, 140-147 (2004).
B. D. Watson, W. D. Dietrich, R. Busto, et al., Ann. Neurol., 17, No. 5, 497-504 (1985).