Determination of dissolved CO2 concentration and CO2 production rate of mammalian cell suspension culture based on off-gas measurement
Tài liệu tham khảo
Andersen, 1994, The effect of cell-culture conditions on the oligosaccharide structures of secreted glycoproteins, Curr. Opin. in Biotechnol., 5, 546, 10.1016/0958-1669(94)90072-8
Bonarius, 1995, 677
Bonarius, 1995, Determination of the respiration quotient in mammalian cell culture in bicarbonate buffered media, Biotechnol. Bioeng., 45, 524, 10.1002/bit.260450610
Chen, 2000, Nutrient-feed control in fed-batch fermenting, Gen. Eng. News, 20, 102
Freshney, 1994
Gambhir, 1999, Analysis of the use of fortified medium in continuous culture of mammalian cells, Cytotechnology, 31, 243, 10.1023/A:1008026613975
Garnier, 1996, Dissolved carbon dioxide accumulation in a large scale and high density production of TGFβ receptor with baculovirus infected Sf-9 cells, Cytotechnology, 22, 53, 10.1007/BF00353924
Gray, 1996, CO2 in large-scale and high-density CHO cell perfusion culture, Cytotechnology, 22, 65, 10.1007/BF00353925
Guyton, 1991
Itagaki, 1974, Exp. Cell Res., 83, 351, 10.1016/0014-4827(74)90349-8
Kasche, 1994, Perfusible and non-perfusible supports with monoclonal antibodies for bioaffinity chromatography of Escherichia coli penicillin amidase within its pH stability range, J. Chromatogr., 660, 137, 10.1016/0021-9673(94)85107-7
Kimura, 1996, Effects of elevated pCO2 and/or osmolality on the growth and recombinant tPA production of CHO cells, Biotechnol. Bioeng., 52, 152, 10.1002/(SICI)1097-0290(19961005)52:1<152::AID-BIT15>3.0.CO;2-Q
Kimura, 1997, Glycosylation of CHO-derived recombinant tPA produced under elevated pCO2, Biotechnol. Prog., 13, 311, 10.1021/bp9700162
Lindl, 1994
Lovrecz, 1994, Use of an on-line gas analysis to monitor recombinant mammalian cell cultures, Cytotechnology, 14, 167, 10.1007/BF00749613
Lüdemann, 1994, Effect of NH3 on the cell growth of a hybridoma cell line, Cytotechnology, 14, 11, 10.1007/BF00772191
Luttmann, 1989, Modellbildung, Simulation und Regelung eines membranbegasten Zellkulturreaktors
Matanguihan, R., Sajan, E., Zachariou, M., Olson, C., Konstantinov, K., 1999. Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration. US Patent Application No. 09/307175.
Matanguihan, R., Sajan, E., Zachariou, M., Olson, C., Michaels, J., Thrift, J., Konstantinov, K., 2001. Solution to the high dissolved CO2 problem in high-density perfusion culture of mammalian cells. Poster Presentation at the Nineteenth ESACT Meeting, Tylösand, Sweden.
Miller, W.M., de Zengotita, V.M., Schmelzer, A.E., Abston, L.R., Chen, Y., 2001. Environmental effects on cell physiology and metabolism: response to elevated pCO2. Oral Presentation at the Nineteenth ESACT Meeting, Tylösand, Sweden.
Oh, 1995, Intracellular responses of productive hybridomas subjected to high osmotic pressure, Biotechnol. Bioeng., 46, 525, 10.1002/bit.260460605
Ozturk, 1996, Engineering challenges in high density cell culture systems, Cytotechnology, 22, 3, 10.1007/BF00353919
Pörtner, 1996, Modelling hybridoma cell growth and metabolism—a comparison of selected models and data, J. Biotechnol., 49, 119, 10.1016/0168-1656(96)01535-0
Qi, H., Jovanovic, G., Michaels, J., Konstantinov, K., 2001. The art and science of micro-sparging in high-density perfusion cultures of animal cells. Poster Presentation at the Nineteenth ESACT Meeting, Tylösand, Sweden.
Reklaitis, 1983
Royce, 1992, Effect of changes in the pH and carbon dioxide evolution rate on the measured respiratory quotient of fermentations, Biotechnol. Bioeng., 40, 1129, 10.1002/bit.260401002
Royce, 1991, Estimation of dissolved carbon dioxide concentrations in aerobic fermentations, AIChE J., 37, 1680, 10.1002/aic.690371111
Ruffieux, 1998, Measurement of volumetric (OUR) and determination of specific (qO2) oxygen uptake rates in animal cell cultures, J. Biotechnol., 63, 85, 10.1016/S0168-1656(98)00046-7
Ryu, 1997, Effect of hypoosmotic stress on hybridoma cell growth and antibody production, Biotechnol. Bioeng., 55, 565, 10.1002/(SICI)1097-0290(19970805)55:3<565::AID-BIT14>3.0.CO;2-F
Stumm, 1996
Taticek, R., Petersen, S., Konstantinov, K., Naveh, D., 1998. ACS Meeting, San Diego, CA.
Yoon, S.K., Ahn, Y.-H., Han, K., 2001. Enhancement of recombinant erythropoietin production in CHO cells in an incubator without CO2 addition. Poster Presentation at the Nineteenth ESACT Meeting, Tylösand, Sweden.
Zanghi, 1999, Bicarbonate concentration and osmolality are key determinants in the inhibition of CHO cell polysialylation under elevated pCO2 or pH, Biotechnol. Bioeng., 65, 182, 10.1002/(SICI)1097-0290(19991020)65:2<182::AID-BIT8>3.0.CO;2-D
Zeng, 1995, Effect of CO2 absorption on the measurement of CO2 evolution rate in aerobic and anaerobic continuous cultures, Appl. Microbiol. Biotechnol., 42, 688, 10.1007/BF00171945
Zhou, 1994, On-line characterization of a hybridoma cell culture process, Biotechnol. Bioeng., 44, 170, 10.1002/bit.260440205
Zhou, 1995, High viable cell concentration fed-batch cultures of hybridoma cells through on-line nutrient feeding, Biotechnol. Bioeng., 46, 579, 10.1002/bit.260460611