Production of spherical pellets by a hot-melt extrusion and spheronization process

International Journal of Pharmaceutics - Tập 242 - Trang 87-92 - 2002
Christopher R Young1, John J Koleng1, James W McGinity1
1Drug Dynamics Institute, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA

Tài liệu tham khảo

Aitken-Nichol, 1996, Hot-melt extrusion of acrylic films, Pharm. Res., 13, 804, 10.1023/A:1016076306279 Berner, 1992, Fundamental concepts in controlled-release, 155 Follonier, 1994, Evaluation of hot-melt extrusion as a new technique for the production of polymer based pellets for sustained release capsules containing high loading of freely soluble drugs, Drug Dev. Ind. Pharm., 20, 1323, 10.3109/03639049409038373 Follonier, 1995, Various ways of modulating the release of diltiazem hydrochloride from hot-melt extruded sustained release pellets prepared using polymeric materials, J. Control. Release, 36, 243, 10.1016/0168-3659(95)00041-6 Gandhi, 1999, Extrusion and spheronization in the development of oral controlled-release dosage forms, Pharm. Sci. Technol. Today, 2, 160, 10.1016/S1461-5347(99)00136-4 Lee, 1992, Diffusion-controlled matrix systems, 155 McGinity, 2000, Hot-melt extrusion technology, 19, 203 Repka, 2000, Physical–mechanical, moisture absorption and bioadhesive properties of hydroxypropylcellulose hot-melt extruded films, Biomaterials, 21, 1509, 10.1016/S0142-9612(00)00046-6 Repka, 1999, Influence of plasticizers and drugs on the physical–mechanical properties of hydroxypropylcellulose films prepared by hot-melt extrusion, Drug Dev. Ind. Pharm., 25, 625, 10.1081/DDC-100102218 Wicks, 1986, Free volume and coatings formulator, J. Coating Technol., 58, 23 Zheng, 1999, Properties of sustained release tablets prepared by hot-melt extrusion, Pharm. Dev. Technol., 4, 241, 10.1081/PDT-100101358