Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X7 antagonists

Bioorganic & Medicinal Chemistry Letters - Tập 20 - Trang 4951-4954 - 2010
Robert J. Gleave1, Daryl S. Walter1, Paul J. Beswick1, Elena Fonfria1, Anton D. Michel1, Shilina A. Roman1, Sac-Pham Tang1
1Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK

Tài liệu tham khảo

Colomar, 2005, J. Biol. Chem., 278, 30732, 10.1074/jbc.M304534200 Hughes, 2007, Purinergic Signalling, 3, 163, 10.1007/s11302-006-9031-1 Collo, 1997, Neuropharmacology, 36, 1277, 10.1016/S0028-3908(97)00140-8 Chessell, 2005, Pain, 114, 386, 10.1016/j.pain.2005.01.002 Labasi, 2002, J. Immunol., 168, 6436, 10.4049/jimmunol.168.12.6436 Romagnoli, 2008, Expert Opin. Ther. Targets, 12, 647, 10.1517/14728222.12.5.647 Chambers, 2010, Bioorg. Med. Chem. Lett. Gordon, 1993, Tetrahedron Lett., 34, 1901, 10.1016/S0040-4039(00)91958-0 Clarke, 2001, Xenobiotica, 31, 591, 10.1080/00498250110057350 Galia, 1998, Pharm. Res., 15, 698, 10.1023/A:1011910801212