Flexible Management of Enzymatic Digestion Improves Human Islet Isolation Outcome from Sub‐Optimal Donor Pancreata

American Journal of Transplantation - Tập 3 - Trang 1135-1142 - 2003
A.N. Balamurugan1,2, Yigang Chang2, John J. Fung1, Massimo Trucco2, Rita Bottino2
1Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
2Department of Pediatrics, Division of Immunogenetics, Diabetes Institute, University of Pittsburgh, School of Medicine, Rangos Research Center, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA

Tài liệu tham khảo

Shapiro, 2000, Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid‐free immunosuppressive regimen, N Engl J Med, 343, 230, 10.1056/NEJM200007273430401 Ryan, 2002, Successful islet transplantation: continued insulin reserve provides long‐term glycemic control, Diabetes, 51, 2148, 10.2337/diabetes.51.7.2148 Hakim, 2001, Recent developments and future prospects in pancreatic and islet transplantation, Diabetes Obes Metab, 3, 9, 10.1046/j.1463-1326.2001.00138.x Hering, 2002, Impact of two‐layer pancreas preservation on islet isolation and transplantation, Transplantation, 74, 1813, 10.1097/00007890-200212270-00033 Ricordi, 1988, Automated method for isolation of human pancreatic islets, Diabetes, 37, 413, 10.2337/diab.37.4.413 Matsumoto, 2003, Improved islet yields from Macaca nemestrina and marginal human pancreata after two‐layer method preservation and endogenous trypsin inhibition, Am J Transplant, 3, 53, 10.1034/j.1600-6143.2003.30110.x Lakey, 1999, Intraductal collagenase delivery into the human pancreas using syringe loading or controlled perfusion, Cell Transplant, 8, 285, 10.1177/096368979900800309 Kenmochi, 2000, Improved quality and yield of islets isolated from human pancreata using a two‐step digestion method, Pancreas, 20, 184, 10.1097/00006676-200003000-00012 London, 1995, Clinical studies of human islet transplantation, Ann R Coll Surg Engl, 77, 263 Morrison, 2002, Islet yield remains a problem in islet autotransplantation, Arch Surg, 137, 80, 10.1001/archsurg.137.1.80 Paraskevas, 2000, Cell loss in isolated human islets occurs by apoptosis, Pancreas, 20, 270, 10.1097/00006676-200004000-00008 Lakey, 1996, Variables in organ donors that affect the recovery of human islets of Langerhans, Transplantation, 61, 1047, 10.1097/00007890-199604150-00010 Bottino, 2002, Islet/pancreas transplantation: challenges for pediatrics, Pediatric Diabetes, 3, 210, 10.1034/j.1399-5448.2002.30408.x Mahler, 1999, Evidence for a significant correlation of donor pancreas morphology and the yield of isolated purified human islets, J Mol Med, 77, 87, 10.1007/s001090050308 Lakey, 2001, Serine‐protease inhibition during islet isolation increases islet yield from human pancreases with prolonged ischemia, Transplantation, 72, 565, 10.1097/00007890-200108270-00003 Tanaka, 2002, A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity, Proc Natl Acad Sci USA, 99, 12363, 10.1073/pnas.192445199 Bottino, 2002, Preservation of human islet cell functional mass by anti‐oxidative action of a novel SOD mimic compound, Diabetes, 51, 2561, 10.2337/diabetes.51.8.2561 Ricordi, 1995, Automated method for pancreatic islet separation., 433 Toso, 2002, Factors affecting human islet of Langerhans isolation yields, Transplant Proc, 34, 826, 10.1016/S0041-1345(01)02925-6 Ricordi, 1994, Islet isolation assessment, 130 Ling, 1996, Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation, J Clin Invest, 98, 2805, 10.1172/JCI119108 Pipeleers, 1991, Transplantation of purified islet cells in diabetic rats. I. Standardization of islet cell grafts, Diabetes, 40, 908, 10.2337/diab.40.7.908 Hauptman, 1997, Medical progress: procurement and allocation of solid organs for transplantation, N Engl J Med, 336, 422, 10.1056/NEJM199702063360607 Clayton, 2000, Non‐heart‐beating organ donors: a potential source of islets for transplantation, Transplantation, 69, 2094, 10.1097/00007890-200005270-00021 Fraker, 2002, Use of oxygenated perfluorocarbon toward making every pancreas count, Transplantation, 74, 1811, 10.1097/00007890-200212270-00032 Brandhorst, 1994, Influence of donor data and organ procurement on human islet isolation, Transplant Proc, 26, 592 Chen, 2001, Characterization of an important enzymatic component in collagenase that is essential for the effective digestion of the human and porcine pancreas, Cell Transplant, 10, 709, 10.3727/000000001783986189 Gray, 1987, Developments in isolated pancreatic islet transplantation, Transplantation, 43, 321, 10.1097/00007890-198703000-00001 Vargas, 2001, Engraftment of islets obtained by collagenase and Liberase in diabetic rats: a comparative study, Pancreas, 23, 406, 10.1097/00006676-200111000-00012 Schwartz, 1984, Morphological changes in pancreatic fragments prepared for transplantation by collagenase treatment, Transplantation, 38, 273, 10.1097/00007890-198409000-00015 Rehman, 2003, Protection of islets by in situ peptide mediated transduction of the IB kinase (IKK) inhibitor nemo binding domain (NBD) peptide, J Biol Chem, 278, 9862, 10.1074/jbc.M207700200 Pileggi, 2001, Heme oxygenase‐1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation, Diabetes, 50, 1983, 10.2337/diabetes.50.9.1983