Smad Translocation and Growth Suppression in Lens Epithelial Cells by Endogenous TGFβ2 during Wound Repair

Cousins, 1991, Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor, Invest. Ophthalmol. Vis. Sci., 32, 2201 Gordon-Thomson, 1998, Differential cataractogenic potency of TGF-β1, -β2, and -β3 and their expression in the postnatal rat eye, Invest. Ophthalmol. Vis. Sci., 39, 1399 Hales, 1995, Cataract induction in lenses cultured with transforming growth factor-β, Invest. Ophthalmol. Vis. Sci., 36, 1709 Harding, 1961, A propagated stimulation of DNA synthesis and cell division, Exp. Cell Res., 25, 326, 10.1016/0014-4827(61)90283-X Jones, 1999, TGF-β1 stimulates the release of pre-formed bFGF from renal proximal tubular cells, Kidney Int., 56, 83, 10.1046/j.1523-1755.1999.00517.x Kokawa, 1996, High total TGF-β2 in normal human tears, Curr. Eye Res., 15, 341, 10.3109/02713689609007630 Kurosaka, 1994, Inhibitory effect of TGF-β2 in human aqueous humor on bovine lens epithelial cell proliferation, Invest. Ophthalmol. Vis. Sci., 35, 3408 Lo, 1999, Ubiquitin-dependent degradation of TGF-β-activated Smad2, Nature Cell Biol., 1, 472, 10.1038/70258 Massague, 1990, The transforming growth factor-β family, Ann. Rev. Cell Biol., 6, 597, 10.1146/annurev.cb.06.110190.003121 Massague, 2000, How cells read TGF-β signals, Nature Rev. Mol. Cell Biol., 1, 169, 10.1038/35043051 Miller, 1990, Transforming growth factor β: a family of growth regulatory peptides, Ann. N.Y. Acad. Sci., 593, 208, 10.1111/j.1749-6632.1990.tb16113.x Mita, 1999, Functional difference of TGF-β isoforms regulating corneal wound healing after excimer laser keratectomy, Exp. Eye Res., 68, 513, 10.1006/exer.1998.0627 Nishi, 1996, Effects of the cytokines on the proliferation of and collagen synthesis by human cataract lens epithelial cells, Br. J. Ophthalmol., 80, 63, 10.1136/bjo.80.1.63 Oharazawa, 1999, The effects of extracellular matrix on cell attachment, proliferation and migration in a human lens epithelial cell line, Exp Eye Res., 69, 603, 10.1006/exer.1999.0723 Petridou, 2000, TGF-β receptor expression and Smad2 localization are cell density dependent in fibroblasts, Invest. Ophthalmol. Vis. Sci., 41, 89 Piek, 1999, Specificity, diversity, and regulation in TGF-β superfamily signaling, FASEB J., 13, 2105, 10.1096/fasebj.13.15.2105 Qi, 1999, Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat, Proc. Natl. Acad. Sci. U.S.A., 96, 2345, 10.1073/pnas.96.5.2345 Rakic, 1997, Separation of fibers from the capsule enhances mitotic activity of human lens epithelium, Exp. Eye Res., 64, 67, 10.1006/exer.1996.0179 Rothstein, 1964, Response to injury in the lens epithelium of the bullfrog (Rana catesbeina), Exp. Cell Res., 35, 548, 10.1016/0014-4827(64)90142-9 Saika, 1998, Immunolocalization of prolyl 4-hydroxylase subunits, α-smooth muscle actin, and extracellular matrix components in human lens capsules with lens implants, Exp. Eye Res., 66, 283, 10.1006/exer.1997.0434 Saika, 1996, Lens epithelial cell outgrowth and matrix formation on intraocular lenses in rabbit eyes, J. Cataract Refract. Surg., 22, 835, 10.1016/S0886-3350(96)80171-4 Saika, 2000, Role of lumican in the corneal epithelium during wound healing, J. Biol. Chem., 275, 2607, 10.1074/jbc.275.4.2607 Shibuya, 1996, TAB1: an activator of the TAK1 MAPKKK in TGF-β signal transduction, Science, 272, 1179, 10.1126/science.272.5265.1179 Uga, 1981, Wound healing in the mouse lens, Exp. Eye Res., 32, 175, 10.1016/0014-4835(81)90006-3 Wang, 1997, Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition, Proc. Natl. Acad. Sci. U.S.A., 94, 2386, 10.1073/pnas.94.6.2386 Weinsieder, 1976, Aqueous humor in lens repair and cell proliferation, Exp. Eye Res., 23, 355, 10.1016/0014-4835(76)90134-2