Age-associated changes in gene expression in human brain and isolated neurons

Bahar, 2006, Increased cell-to-cell variation in gene expression in ageing mouse heart, Nature, 441, 1011, 10.1038/nature04844 Berchtold, 2008, Gene expression changes in the course of normal brain aging are sexually dimorphic, Proc. Natl. Acad. Sci. U. S. A., 105, 15605, 10.1073/pnas.0806883105 Blalock, 2011, Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease, J. Chem. Neuroanat., 42, 118, 10.1016/j.jchemneu.2011.06.007 Burton, 2011, Mineralocorticoid antagonism: a novel way to treat sarcopenia and physical impairment in older people?, Clin. Endocrinol. (Oxf.)., 75, 725, 10.1111/j.1365-2265.2011.04148.x Colantuoni, 2011, Temporal dynamics and genetic control of transcription in the human prefrontal cortex, Nature, 478, 519, 10.1038/nature10524 Fraser, 2005, Aging and gene expression in the primate brain, PLoS Biol., 3, e274, 10.1371/journal.pbio.0030274 Gibbs, 2010, Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain, PLoS Genet., 6, e1000952, 10.1371/journal.pgen.1000952 Hamatani, 2004, Age-associated alteration of gene expression patterns in mouse oocytes, Hum. Mol. Genet., 13, 2263, 10.1093/hmg/ddh241 Hernandez, 2012, Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain, Neurobiol. Dis., 47, 20, 10.1016/j.nbd.2012.03.020 Huang, 2009, Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists, Nucleic Acids Res., 37, 1, 10.1093/nar/gkn923 Huang, 2009, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources, Nat. Protoc., 4, 44, 10.1038/nprot.2008.211 Huizing, 2001, Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33, Gene, 264, 241, 10.1016/S0378-1119(01)00333-X Jászai, 2002, Cloning and expression of Ventrhoid, a novel vertebrate homologue of the Drosophila EGF pathway gene rhomboid, Mech. Dev., 113, 73, 10.1016/S0925-4773(01)00655-4 Jin, 2011, Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo, Circulation, 123, 1963, 10.1161/CIRCULATIONAHA.110.000034 Kadish, 2009, Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment, J. Neurosci., 29, 1805, 10.1523/JNEUROSCI.4599-08.2009 Kang, 2011, Spatio-temporal transcriptome of the human brain, Nature, 478, 483, 10.1038/nature10523 Kirkwood, 2011, Systems biology of ageing and longevity, Philos. Trans. R. Soc. Lond. B Biol. Sci., 366, 64, 10.1098/rstb.2010.0275 Langfelder, 2008, WGCNA: an R package for weighted correlation network analysis, BMC Bioinformatics, 9, 559, 10.1186/1471-2105-9-559 Liu, 2011, Characterization of age-related gene expression profiling in bone marrow and epididymal adipocytes, BMC Genomics, 12, 212, 10.1186/1471-2164-12-212 Lu, 2004, Gene regulation and DNA damage in the ageing human brain, Nature, 429, 883, 10.1038/nature02661 Martin, 2011, The biology of aging: 1985-2010 and beyond, FASEB J., 25, 3756, 10.1096/fj.11-1102.ufm Miller, 2010, Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways, Proc. Natl. Acad. Sci. U. S. A., 107, 12698, 10.1073/pnas.0914257107 Miller, 2008, A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging, J. Neurosci., 28, 1410, 10.1523/JNEUROSCI.4098-07.2008 Nakamura, 2012, Identification of blood biomarkers of aging by transcript profiling of whole blood, Biochem. Biophys. Res. Commun., 418, 313, 10.1016/j.bbrc.2012.01.018 Oberdick, 1988, A Purkinje cell differentiation marker shows a partial DNA sequence homology to the cellular sis/PDGF2 gene, Neuron, 1, 367, 10.1016/0896-6273(88)90186-9 Oh, 2011, Reciprocal phylogenetic conservation of molecular aging in mouse and human brain, Neurobiol. Aging, 32, 1331, 10.1016/j.neurobiolaging.2009.08.004 Pfaffl, 2001, A new mathematical model for relative quantification in real-time RT-PCR, Nucleic Acids Res., 29, e45, 10.1093/nar/29.9.e45 Rodwell, 2004, A transcriptional profile of aging in the human kidney, PLoS Biol., 2, e427, 10.1371/journal.pbio.0020427 Sahin, 2011, Telomere dysfunction induces metabolic and mitochondrial compromise, Nature, 470, 359, 10.1038/nature09787 Scott, 1995, Cloning of the sulphamidase gene and identification of mutations in Sanfilippo A syndrome, Nat. Genet., 11, 465, 10.1038/ng1295-465 Shammas, 2011, Telomeres, lifestyle, cancer, and aging, Curr. Opin. Clin. Nutr. Metab. Care, 14, 28, 10.1097/MCO.0b013e32834121b1 Trabzuni, 2011, Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies, J. Neurochem., 119, 275, 10.1111/j.1471-4159.2011.07432.x Tranah, 2011, Mitochondrial-nuclear epistasis: implications for human aging and longevity, Ageing Res. Rev., 10, 238, 10.1016/j.arr.2010.06.003 Zahn, 2007, AGEMAP: a gene expression database for aging in mice, PLoS Genet., 3, e201, 10.1371/journal.pgen.0030201 Zahn, 2006, Transcriptional profiling of aging in human muscle reveals a common aging signature, PLoS Genet., 2, e115, 10.1371/journal.pgen.0020115 Zheng, 2010, PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease, Sci. Transl. Med., 2, 52ra73, 10.1126/scitranslmed.3001059