Circadian control of p75 neurotrophin receptor leads to alternate activation of Nrf2 and c-Rel to reset energy metabolism in astrocytes via brain-derived neurotrophic factor

Rudic, 2004, BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis, PLoS Biol., 2, e377, 10.1371/journal.pbio.0020377

Kalsbeek, 2014, Circadian control of glucose metabolism, Mol. Metab., 3, 372, 10.1016/j.molmet.2014.03.002

Schmutz, 2010, The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors, Genes. Dev., 24, 345, 10.1101/gad.564110

Vukolic, 2010, Role of mutation of the circadian clock gene Per2 in cardiovascular circadian rhythms, Am. J. Physiol. Regul. Integr. Comp. Physiol., 298, R627, 10.1152/ajpregu.00404.2009

Lamont, 2005, The central and basolateral nuclei of the amygdala exhibit opposite diurnal rhythms of expression of the clock protein Period2, Proc. Natl. Acad. Sci. USA, 102, 4180, 10.1073/pnas.0500901102

Harbour, 2014, Phase differences in expression of circadian clock genes in the central nucleus of the amygdala, dentate gyrus, and suprachiasmatic nucleus in the rat, PLoS One, 7, e103309, 10.1371/journal.pone.0103309

Hood, 2010, Endogenous dopamine regulates the rhythm of expression of the clock protein PER2 in the rat dorsal striatum via daily activation of D2 dopamine receptors, J. Neurosci., 30, 14046, 10.1523/JNEUROSCI.2128-10.2010

Rios, 2014, Neurotrophins and the regulation of energy balance and body weight, Handb. Exp. Pharmacol., 220, 283, 10.1007/978-3-642-45106-5_11

K. Marosi, M.P. Mattson, BDNF mediates adaptive brain and body responses to energetic challenges. 25:89-98; 2014.

Fargali, 2012, Role of neurotrophins in the development and function of neural circuits that regulates energy homeostasis, J. Mol. Neurosci., 48, 654, 10.1007/s12031-012-9790-9

Chao, 1995, P75 and Trk: a two-receptor system, Trends Neurosci., 18, 321, 10.1016/0166-2236(95)93922-K

Baeza-Raja, 2013, p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks, J. Neurosci., 33, 10221, 10.1523/JNEUROSCI.2757-12.2013

Baeza-Raja, 2012, p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity, Proc. Natl. Acad. Sci. USA, 109, 5838, 10.1073/pnas.1103638109

Baeza-Raja, 2016, p75 neurotrophin receptor regulates energy balance in obesity, Cell Rep., 14, 255, 10.1016/j.celrep.2015.12.028

Park, 2013, Neurotrophin regulation of neural circuit development and function, Nat. Rev. Neurosci., 14, 7, 10.1038/nrn3379

Sato, 2017, Releasing mechanism of neurotrophic factors via polysialic acid, Vitam. Horm., 104, 89, 10.1016/bs.vh.2016.11.004

Santos, 2010, Regulation of local translation at synapse by BDNF, Prog. Neuobiol., 92, 505, 10.1016/j.pneurobio.2010.08.004

Martin, 2013, Regulation of neurotrophic factors and energy metabolism by antidepressants in astrocytes, Curr. Drug Targets, 14, 1308, 10.2174/1389450111314110009

Vannucci, 1997, Glucose transporter proteins in brain: delivery of glucose to neurons and glia, Glia, 21, 2021, 10.1002/(SICI)1098-1136(199709)21:1<2::AID-GLIA2>3.0.CO;2-C

Maher, 1991, Expression of two glucose transporters, GLUT1 and GLUT3, in cultured cerebellar neurons: evidence for neuron-specific expression of GLUT3, Mol. Cell. Neurosci., 2, 351, 10.1016/1044-7431(91)90066-W

Simpson, 2008, The facilitative glucose transporter GLUT3: 20 years of distinction, Am. J. Physiol. Endocrinol. Metab., 295, E242, 10.1152/ajpendo.90388.2008

Bélanger, 2011, Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation, Cell Metab., 14, 724, 10.1016/j.cmet.2011.08.016

Dityatev, 2011, Molecular signals of plasticity at the tetrapartite synapse, Curr. Opin. Neurobiol., 21, 353, 10.1016/j.conb.2010.12.006

Fuxe, 2012, Extrasynaptic neurotransmission in the modulation of brain function. Focus on the striatal neuronal-glial networks, Front. Physiol., 3, 136, 10.3389/fphys.2012.00136

Del Rio, 2015, Neuron-glia crosstalk in the autonomic nervous system and its possible role in the progression of metabolic syndrome: a new hypothesis, Front. Physiol., 6, 350, 10.3389/fphys.2015.00350

P.G. Haydon, The evolving view of astrocytes. Cerebrum pii: cer-12-16, 2016.

Hertz, 2017, Integration between glycolysis and glutamate-glutamine cycle flux may explain preferential glycolytic increase during brain activation, requiring glutamate, Front. Integr. Neurosci., 11, 00018, 10.3389/fnint.2017.00018

Dienel, 2015, Contributions of glycogen to astrocytic energetics during brain activation, Metab. Brain Dis., 30, 281, 10.1007/s11011-014-9493-8

DiNuzzo, 2015, Monoaminergic control of cellular glucose utilization by glycogenolysis in neocortex and hippocampus, Neurochem. Res., 40, 2493, 10.1007/s11064-015-1656-4

Matsui, 2011, Brain glycogen decreases during prolonged exercise, J. Physiol., 589, 3383, 10.1113/jphysiol.2011.203570

Matsui, 2012, Brain glycogen supercompensation following exhaustive exercise, J. Physiol., 590, 607, 10.1113/jphysiol.2011.217919

Matsui, 2015, Brain glycogen decreases during intense exercise without hypoglycemia: the possible involvement of serotonin, Neurochem. Res., 40, 1333, 10.1007/s11064-015-1594-1

DiNuzzo, 2017, Brain energetics during the sleep-wake cycle, Curr. Opin. Neurobiol., 47, 65, 10.1016/j.conb.2017.09.010

Kapogiannis, 2011, Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease, Lancet Neurol., 10, 187, 10.1016/S1474-4422(10)70277-5

Duran, 2013, Impairment in long-term memory formation and learning-dependent synaptic plasticity in mice lacking glycogen synthase in the brain, J. Cereb. Blood Flow Metab., 33, 550, 10.1038/jcbfm.2012.200

Lanciotti, 2013, Astrocytes: emerging stars in leukodystrophy pathogenesis, Transl. Neurosci., 4, 10.2478/s13380-013-0118-1

Ohira, 2005, A truncated tropomyosin-related kinase B receptor, T1, regulates glial cell morphology via Rho GDP dissociation inhibitor 1, J. Neurosci., 25, 1343, 10.1523/JNEUROSCI.4436-04.2005

Wojnacki, 2014, Rho GTPases at the crossroad of signaling networks in mammals: impact of Rho-GTPase on microtubule organization and dynamics, Small GTPase, 5, e28430, 10.4161/sgtp.28430

Wang, 2016, Lim kinase, a bi-functional effector in injury-induced structural plasticity of synapses, Neural Regen. Res., 11, 1029, 10.4103/1673-5374.187018

Ohira, 2009, A new aspect of the TrkB signaling pathway in neural plasticity, Curr. Neuropharmacol., 7, 276, 10.2174/157015909790031210

Dransart, 2005, RhoGDIs revisited: novel roles in Rho regulation, Traffic, 6, 957, 10.1111/j.1600-0854.2005.00335.x

Cherfils, 2013, Regulation of small GTPases by GEFs, Gaps, and GDIs, Physiol. Rev., 93, 269, 10.1152/physrev.00003.2012

Dovas, 2010, Serine 34 phosphorylation of rho quinine dissociation inhibitor (RhoGDIα) links signaling from conventional protein kinase C to RhoGTPase in cell adhesion, J. Biol. Chem., 285, 23296, 10.1074/jbc.M109.098129

DerMardirossian, 2004, Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase, Mol. Cell, 15, 117, 10.1016/j.molcel.2004.05.019

MacVicar, 1987, Morphological differentiation of cultured astrocytes is blocked by cadmium or cobalt, Brain Res., 420, 175, 10.1016/0006-8993(87)90256-3

Shain, 1987, Morphology of astroglial cells is controlled by β-adrenergic receptors, J. Cell Biol., 105, 2307, 10.1083/jcb.105.5.2307

Ohira, 2007, Truncated TrkB-T1 regulates the morphology of neocortical layer I astrocytes in adult rat brain slices, Eur. J. Neurosci., 25, 406, 10.1111/j.1460-9568.2007.05282.x

Dobrowsky, 1994, Activation of the sphinogomyelin cycle through the low-affinity neurotrophin receptor, Science, 265, 1596, 10.1126/science.8079174

Mathias, 1998, Signal transduction of stress via ceramide, Biochem. J., 335, 465, 10.1042/bj3350465

Dobrowsky, 1998, Coupling of the p75 neurotrophin receptor to sphingolipid signaling, Ann. N. Y. Acad. Sci., 845, 32, 10.1111/j.1749-6632.1998.tb09660.x

Müller, 1995, PKCζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid, EMBO J., 14, 1961, 10.1002/j.1460-2075.1995.tb07188.x

Yamashita, 2003, The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI, Nat. Neurosci., 6, 461, 10.1038/nn1045

Harrington, 2008, The role of Kalirin9 in p75/nogo receptor-mediated RhoA activation in cerebellar granule neurons, J. Biol. Chem., 283, 24690, 10.1074/jbc.M802188200

Gong, 1999, Differential stimulation of PKC phosphorylation of potassium channels by ZIP and ZIP2, Science, 285, 1565, 10.1126/science.285.5433.1565

Puls, 1997, Interaction of protein kinase C ζ with ZIP, a novel protein kinase-C-binding protein, Proc. Natl. Acad. Sci. USA, 94, 6191, 10.1073/pnas.94.12.6191

Ishii, 2013, Sequestosome1/p62: a regulator of redox-sensitive voltage-activated potassium channels, arterial remodeling, inflammation, and neurite outgrowth, Free Radic. Biol. Med., 65, 102, 10.1016/j.freeradbiomed.2013.06.019

Geetha, 2003, Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling, J. Biol. Chem., 278, 4730, 10.1074/jbc.M208468200

Moscat, 2006, Signal integration and diversification through the p62 scaffold protein, TRENDS Biochem. Sci., 32, 95, 10.1016/j.tibs.2006.12.002

Kim, 2004, Modulation of delayed rectifier potassium channel by protein kinase C zeta-containing signaling complex in pheochromocytoma cells, Neuroscience, 125, 359, 10.1016/j.neuroscience.2003.08.004

Kim, 2005, Modulation of delayed rectifier potassium channels by alpha1-adrenergic activation via protein kinase C zeta and p62 in PC12 cells, Neurosci. Lett., 387, 43, 10.1016/j.neulet.2005.07.016

Roy, 1996, Manipulation of the delayed rectifier Kv1.5 potassium channel in glial cells by antisense oligodeoxynucleotides, Glia, 18, 177, 10.1002/(SICI)1098-1136(199611)18:3<177::AID-GLIA2>3.0.CO;2-X

Moreno, 2007, Role of protein kinase C ζ and its adaptor protein p62 in voltage-gated potassium channel modulation in pulmonary arteries, Mol. Pharmacol., 72, 1301, 10.1124/mol.107.037002

Moreno, 2014, Ceramide mediates acute oxygen sensing in vascular tissues, Antioxid. Redox Signal., 20, 1, 10.1089/ars.2012.4752

Cogolludo, 2009, Activation of neutral shingomyelinase is involved in acute hypoxic pulmonary vasoconstriction, Cardiovasc. Res., 82, 296, 10.1093/cvr/cvn349

Firth, 2011, Functional ion channels in human pulmonary artery smooth muscle cells: voltage-dependent cation channels, Pulm. Circ., 1, 48, 10.4103/2045-8932.78103

Waheed, 2010, Extracellular signal-regulated kinase and GEF-H1 mediate depolarization-induced Rho activation and paracellular permeability increase, Am. J. Physiol. Cell. Physiol., 298, C1376, 10.1152/ajpcell.00408.2009

Kosaka, 2010, Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells, J. Biochem., 147, 73, 10.1093/jb/mvp149

Mann, 2015, Introduction to Special Issue on ‘Nerf2 regulated redox signaling and metabolism in physiology and medicine’, Free Radic. Biol. Med., 88, 91, 10.1016/j.freeradbiomed.2015.08.002

Itoh, 1997, An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements, Biochem. Biophys. Res. Commun., 236, 313, 10.1006/bbrc.1997.6943

Ishii, 2000, Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages, J. Biol. Chem., 275, 16023, 10.1074/jbc.275.21.16023

Ishii, 2004, Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal, Circ. Res., 94, 609, 10.1161/01.RES.0000119171.44657.45

Blanquet, 1998, Neurotrophin-induced activation of casein kinase 2 in rat hippocampal slices, Neuroscience, 86, 739, 10.1016/S0306-4522(98)00087-6

Schael, 2013, Casein kinase 2 phosphorylation of protein kinase C and casein kinase 2 substrate in neurons (PACSIN) 1 protein regulates neuronal spine formation, J. Biol. Chem., 288, 9303, 10.1074/jbc.M113.461293

Arevalo, 2006, Activation of casein kinase II and inhibition of phosphatase and tensin homologue deleted on chromosome 10 phosphatase by nerve growth factor/p75NTR inhibit glycogen synthase kinase-3β and stimulate axonal growth, Mol. Biol. Cell, 17, 3369, 10.1091/mbc.e05-12-1144

Castello, 2017, CK2–An emerging target for neurological and psychiatric disorders, Pharmaceuticals, 10, 10.3390/ph10010007

Kobayashi, 2009, The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds, Mol. Cell. Biol., 29, 493, 10.1128/MCB.01080-08

Huang, 2000, Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2, Proc. Natl. Acad. Sci. USA, 97, 12475, 10.1073/pnas.220418997

Pi, 2007, Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2, Free Radic. Biol. Med., 42, 1797, 10.1016/j.freeradbiomed.2007.03.001

Apopa, 2008, Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells, J. Biochem. Mol. Toxicol., 22, 63, 10.1002/jbt.20212

Afonyuskin, 2011, Involvement of CK2 in activation of electrophilic genes in endothelial cells by oxidized phospholipids, J. Lipid Res., 52, 98, 10.1194/jlr.M009480

Olsen, 2012, Downregulation of protein kinase CK2 induces autophagic cell death through modulation of the mTOR and MAPK signaling pathways in human glioblastoma cells, Int. J. Oncol., 41, 1967, 10.3892/ijo.2012.1635

Ji, 2013, The role of protein kinase CK2 in glioblastoma development, Clin. Cancer Res., 19, 6335, 10.1158/1078-0432.CCR-13-2478

Zheng, 2013, Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma, Clin. Cancer Res., 19, 6484, 10.1158/1078-0432.CCR-13-0265

Kanamori, 2015, Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients, Neuro-Oncology, 17, 555, 10.1093/neuonc/nou282

Cong, 2013, ERK and PI3K signaling cascades induce Nrf2 activation and regulate cell viability partly through Nrf2 in human glioblastoma cells, Oncol. Rep., 30, 715, 10.3892/or.2013.2485

Kraft, 2004, Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult, J. Neurosci., 24, 1101, 10.1523/JNEUROSCI.3817-03.2004

Heiss, 2013, Glucose availability is a decisive factor for Nrf2-mediated gene expression, Redox Biol., 1, 359, 10.1016/j.redox.2013.06.001

Uruno, 2016, Nrf2-mediated regulation of skeletal muscle glycogen metabolism, Mol. Cell. Biol., 36, 1655, 10.1128/MCB.01095-15

Itoh, 2015, Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria, J. Clin. Biochem. Nutr., 56, 91, 10.3164/jcbn.14-134

Holmström, 2016, The multifaceted role of Nrf2 in mitochondrial function, Curr. Opin. Toxicol., 1, 80, 10.1016/j.cotox.2016.10.002

Lee, 2016, Regulation of protein kinase CK2 catalytic activity by protein kinase C and phospholipase D2, Biochimie, 121, 131, 10.1016/j.biochi.2015.12.005

Song, 2003, Inhibition of rat sympathetic neuron apoptosis by ceramide. Role of p75NTR in ceramide generation, Neuropharmacology, 45, 1130, 10.1016/S0028-3908(03)00284-3

Jung, 2016, Short-chain C2 ceramide induces heme oxygenase-1 expression by upregulating AMPK and MAPK signaling pathways in rat primary astrocytes, Neurochem. Int., 94, 39, 10.1016/j.neuint.2016.02.004

Augé, 1996, The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation, J. Biol. Chem., 271, 19251, 10.1074/jbc.271.32.19251

Kinscherf, 1997, Modified low density lipoprotein delivers substrate for ceramide formation and stimulates the sphingomyelin-ceramide pathway in human macrophages, FEBS Lett., 405, 55, 10.1016/S0014-5793(97)00157-9

Halasiddappa, 2013, Oxidized phospholipids induce ceramide accumulation in RAW 264.7 macrophages: role of ceramide synthases, PLoS One, 8, e70002, 10.1371/journal.pone.0070002

Camaré, 2016, The neutral sphingomyelinase-2 is involved in angiogenic signaling triggered by oxidized LDL, Free Radic. Biol. Med., 93, 204, 10.1016/j.freeradbiomed.2016.02.006

Scarlatti, 2003, Resvertrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling, FASEB J., 17, 2339, 10.1096/fj.03-0292fje

Sala, 2003, Resveratrol structure and ceramide-associated growth inhibition in prostate cancer cells, Drugs Exp. Clin. Res., 29, 263

Moussavi, 2006, Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells, Carcinogenesis, 27, 1636, 10.1093/carcin/bgi371

Thayyullathil, 2014, ROS-dependent prostate apoptosis response-4 (Par-4) upregulation and ceramide generation are the prime signaling events associated with curcumin-induced autophagic cell death in human malignant glioma, FEBS Open Bio, 4, 763, 10.1016/j.fob.2014.08.005

Shakor, 1841, Curcumin induces apoptosis of multidrug-resistant human leukemia HL60 cells by complex pathways leading to ceramide accumulation, Biochem. Biophys. Acta, 1672–1682, 2014

Miller, 2002, Direct identification of PTEN phosphorylation sites, FEBS Lett., 528, 145, 10.1016/S0014-5793(02)03274-X

Barata, 2011, The impact of PTEN regulation by CK2 on PI3K-dependent signaling and leukemia cell survival, Adv. Enzyme Regul., 51, 37, 10.1016/j.advenzreg.2010.09.012

Guerra, 2006, Protein kinase CK2 subunits are positive regulators of AKT kinase, Int. J. Oncol., 28, 685

Laplante, 2010, mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis, Proc. Natl. Acad. Sci. USA, 107, 3281, 10.1073/pnas.1000323107

Shaw, 1997, Further evidence that the inhibition of glycogen synthase kinase-3β by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216, FEBS Lett., 416, 307, 10.1016/S0014-5793(97)01235-0

Hemmings, 1984, DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphoatase-1, Nature, 310, 503, 10.1038/310503a0

Roach, 2012, Glycogen and its metabolism: some new developments and old themes, Biochem. J., 441, 763, 10.1042/BJ20111416

Lee, 2001, Activation of Trk neurotrophin receptors in the absence of neurotrophins, Proc. Natl. Acad. Sci. USA, 98, 3555, 10.1073/pnas.061020198

Colino-Oliveira, 2016, BDNF-induced presynaptic facilitation of GABAergic transmission in the hippocampus of young adults is dependent of TrkB and adenosine A2A receptors, Purinergic Signal., 12, 283, 10.1007/s11302-016-9502-y

Sebastião, 2015, Neuromodulation and metamodulation by adenosine: Impact and subtleties upon synaptic plasticity regulation, Brain Res., 1621, 102, 10.1016/j.brainres.2014.11.008

Parri, 2013, Star spangled manner: astrocytes and neurons contribute to adenosine release in the hippocampus, J. Physiol., 591, 3805, 10.1113/jphysiol.2013.259838

Rodrigues, 2015, ATP as a multi-target danger signal in the brain, Front. Neurosci., 9, 10.3389/fnins.2015.00148

Barros-Barbosa, 2016, Adenosine A2A receptor and exto-5’-nucleaotidase/CD73 are upregulated in hippocampal astrocytes of human patients with mesial temporal lobe epilepsy (MTLE), Purinergic Signal, 12, 719, 10.1007/s11302-016-9535-2

Iwakura, 2008, Dopamine D1 receptor-induced signaling through TrkB receptors in striatal neurons, J. Biol. Chem., 283, 15799, 10.1074/jbc.M801553200

Nagatomo, 2017, Dopamine D1 receptor immunoreactivity on fine processes of GFAP-positive astrocytes in the substantia nigra pars reticulate of adult mouse, Front. Neuroanat., 11, 3, 10.3389/fnana.2017.00003

Arias-Carriόn, 2010, Dopaminergic reward system: a short integrative review, Int. Arch. Med., 3, 24, 10.1186/1755-7682-3-24

Shohamy, 2010, Dopamine and adaptive memory, Trends Cogn. Sci., 14, 464, 10.1016/j.tics.2010.08.002

Garris, 1994, Efflux of dopamine from the synaptic cleft in the nucleus accumbens of the rat brain, J. Neurosci., 14, 6084, 10.1523/JNEUROSCI.14-10-06084.1994

Tritsch, 2012, Dopaminergic modulation of synaptic transmission in cortex and striatum, Neuron, 76, 33, 10.1016/j.neuron.2012.09.023

Hutchins, 1973, Effect of depletion of cerebral monoamines on the concentration of glycogen and on amphetamine-induced glycogenolysis in the brain, Br. J. Pharmacol., 48, 19, 10.1111/j.1476-5381.1973.tb08218.x

Requardt, 2010, The biphasic NAD(P)H fluorescence response of astrocytes to dopamine reflects the metabolic actions of oxidative phosphorylation and glycolysis, J. Neurochem., 115, 483, 10.1111/j.1471-4159.2010.06940.x

Lu, 2006, Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation, Am. J. Physiol. Cell. Physiol., 290, C1477, 10.1152/ajpcell.00374.2005

Norrmén, 2014, mTORC1 control PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells, Cell Rep., 9, 646, 10.1016/j.celrep.2014.09.001

Birukova, 2007, Prostaglandins PGE2 and PGI2 promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation, Exp. Cell Res., 313, 2504, 10.1016/j.yexcr.2007.03.036

Zaldua, 2007, Epac signaling pathway involves STEF, a guanine nucleotide exchange factor for Rac, to regulate APP processing, FEBS Lett., 581, 5814, 10.1016/j.febslet.2007.11.053

Oishi, 2012, Regulation of RhoA signaling by the cAMP-dependent phosphorylation of RhoGDIα, J. Biol. Chem., 287, 38705, 10.1074/jbc.M112.401547

Nicchia, 2008, Actin cytoskeleton remodeling governs aquaporin-4 localization in astrocytes, Glia, 56, 1755, 10.1002/glia.20724

Song, 2012, Potassium dependent regulation of astrocyte water permeability is mediated by cAMP signaling, PLoS One, 7, e34936, 10.1371/journal.pone.0034936

Baiguera, 2012, Late-onset Parkinsonism in NFκB/c-Rel-deficient mice, Brain, 135, 2750, 10.1093/brain/aws193

Ho, 2012, UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress, Free Radic. Biol. Med., 53, 383, 10.1016/j.freeradbiomed.2012.05.002

Neumann, 1995, RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A, EMBO J., 14, 1991, 10.1002/j.1460-2075.1995.tb07191.x

Lahdenpohja, 1996, Activation of the protein kinase A increases the DNA-binding and transcriptional activity of c-Rel in T cells, Scad. J. Immunol., 43, 640, 10.1046/j.1365-3083.1996.d01-268.x

Yu, 2000, Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation, FASEB J., 14, 1611, 10.1096/fj.99-0834com

Perreten, 2014, Control of mitochondrial pH by uncoupling protein 4 in astrocytes promotes neuronal survival, J. Biol. Chem., 289, 31014, 10.1074/jbc.M114.570879

Dorseuil, 1992, Inhibition of superoxide production in B lymphocytes by rac antisense oligonucleotides, J. Biol. Chem., 267, 20540, 10.1016/S0021-9258(19)36716-X

Hordijk, 2006, Regulation of NADPH oxidases: the role of Rac proteins, Cir. Res., 98, 453, 10.1161/01.RES.0000204727.46710.5e

Nayernia, 2014, New insights on NOX enzymes in the central nervous system, Antioxid. Redox Signal., 20, 2815, 10.1089/ars.2013.5703

Dienel, 2016, Aerobic glycolysis during brain activation: adrenergic regulation and influence of norepinephrine on astrocytic metabolism, J. Neurochem., 138, 14, 10.1111/jnc.13630

Hertz, 2007, Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis, J. Cereb. Blood Flow Metab., 27, 219, 10.1038/sj.jcbfm.9600343

Huang, 2007, Protein kinase A and casein kinases mediate sequential phosphorylation events in the circadian negative feedback loop, Genes Dev., 21, 3283, 10.1101/gad.1610207

Lin, 2002, A role for caseine kinase 2α in the Drosophila circadian clock, Nature, 420, 816, 10.1038/nature01235

Maier, 2009, A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock, Genes Dev., 23, 708, 10.1101/gad.512209

Tsuchiya, 2009, Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms, Sci. Signal., 2, ra26, 10.1126/scisignal.2000305

Rebholz, 2009, CK2 negatively regulates Gαs signaling, Proc. Natl. Acad. Sci. USA, 106, 14096, 10.1073/pnas.0906857106

Kim, 2009, CK2 is a novel negative regulator of NADPH oxidase and a neuroprotectant in mice after cerebral ischemia, J. Neurosci., 29, 14779, 10.1523/JNEUROSCI.4161-09.2009

Zhou, 2016, 5d, a novel analogue of 3-n-butylphthalide, decreases NADPH oxidase activity through the positive regulation of CK2 after ischemia/reperfusion injury, Oncotarget, 7, 39444, 10.18632/oncotarget.8548

Park, 2001, Phosphorylation of the leucocyte NADPH oxidase subunit p47phox by casein kinase 2: conformation-dependent phosphorylation and modulation of oxidase activity, Biochem. J., 358, 783, 10.1042/bj3580783

Prosser, 1994, Serotonergic phase advances of the mammalian circadian clock involve protein kinase A and K+ channel opening, Brain Res., 644, 67, 10.1016/0006-8993(94)90348-4

Lee, 1999, Inhibition of protein kinase A phase delays the mammalian circadian clock, Brain Res., 835, 350, 10.1016/S0006-8993(99)01600-5

O’Neill, 2012, The essential role of cAMP/Ca2+ signaling in mammalian circadian timekeeping, Biochem. Soc. Trans., 40, 44, 10.1042/BST20110691

Sassone-Corsi, 1998, Coupling gene expression to cAMP signaling: role of CREB and CREM, Int. J. Biochem. Cell Biol., 30, 27, 10.1016/S1357-2725(97)00093-9

Fukuchi, 2005, Transcriptional regulation of neuronal genes and its effect on neural functions: cumulative mRNA expression of PACAP and BDNF genes controlled by calcium and cAMP signals in neurons, J. Pharmacol. Sci., 98, 212, 10.1254/jphs.FMJ05001X4

Deogracias, 2004, Expression of the neurotrophin receptor trkB is regulated by the cAMP/CREB pathway in neurons, Mol. Cell. Neurosci., 26, 470, 10.1016/j.mcn.2004.03.007

Edgar, 2012, Peroxiredoxins are conserved marker of circadian rhythms, Nature, 485, 459, 10.1038/nature11088

Milev, 2015, Circadian redox oscillations and metabolism, Trends Endocrinol. Metab., 26, 430, 10.1016/j.tem.2015.05.012

Tso, 2017, Astrocytes regulate daily rhythms in the suprachiasmatic nucleus and behavior, Curr. Biol., 27, 1055, 10.1016/j.cub.2017.02.037

Brancaccio, 2017, Astrocytes control circadian timekeeping in the suprachiasmatic nucleus via glutamatergic signaling, Neuron, 93, 1420, 10.1016/j.neuron.2017.02.030

Liang, 2000, Role of brain-derived neurotrophic factor in the circadian regulation of the suprachiasmatic pacemaker by light, J. Neurosci., 20, 2978, 10.1523/JNEUROSCI.20-08-02978.2000

Allen, 2005, TrkB-deficient mice show diminished phase shifts of the circadian activity rhythm in response to light, Neurosci. Lett., 378, 150, 10.1016/j.neulet.2004.12.023

Girardet, 2013, Brain-derived neurotrophic factor/TrkB signaling regulates daily astroglial plasticity in the suprachiasmatic nucleus: electron-microscopic evidence in mouse, GLIA, 61, 1172, 10.1002/glia.22509

Reddy, 2010, Healthy clocks, healthy body, healthy mind, Trends Cell. Biol., 20, 36, 10.1016/j.tcb.2009.10.005

Videnovic, 2014, ‘The clocks that time us'—circadian rhtyhms in neurodegerative disorders, Nat. Rev. Neurol., 10, 683, 10.1038/nrneurol.2014.206

Musiek, 2016, Mechanisms linking circadian clocks, sleep, and neurodegeneration, Science, 354, 1004, 10.1126/science.aah4968

Mattis, 2016, Circadian rhythms, sleep, and disorders of aging, Trens. Endocrinol. Metab., 27, 192, 10.1016/j.tem.2016.02.003