The structural and functional connectivity of the amygdala: From normal emotion to pathological anxiety

Behavioural Brain Research - Tập 223 - Trang 403-410 - 2011
M. Justin Kim1, Rebecca A. Loucks1, Amy L. Palmer1, Annemarie C. Brown1, Kimberly M. Solomon1, Ashley N. Marchante1, Paul J. Whalen1
1Department of Psychological & Brain Sciences, Dartmouth College, 6207 Moore Hall, Hanover, NH 03755, USA

Tài liệu tham khảo

Roelofs, 2010, Facing freeze: social threat induces bodily freeze in humans, Psychol Sci, 21, 1575, 10.1177/0956797610384746 Bishop, 2007, Neurocognitive mechanisms of anxiety: an integrative account, Trends Cogn Sci, 11, 307, 10.1016/j.tics.2007.05.008 Ochsner, 2005, The cognitive control of emotion, Trends Cogn Sci., 9, 242, 10.1016/j.tics.2005.03.010 Quirk, 2006, Prefrontal involvement in the regulation of emotion: convergence of rat and human studies, Curr Opin Neurobiol, 16, 723, 10.1016/j.conb.2006.07.004 Bishop, 2004, Prefrontal cortical function and anxiety: controlling attention to threat-related stimuli, Nat Neurosci, 7, 184, 10.1038/nn1173 Simmons, 2008, Anxiety vulnerability is associated with altered anterior cingulate response to an affective appraisal task, Neuroreport, 19, 1033, 10.1097/WNR.0b013e328305b722 Simpson, 2001, Emotion-induced changes in human medial prefrontal cortex: II. During anticipatory anxiety, Proc Natl Acad Sci USA, 98, 688, 10.1073/pnas.98.2.688 Straube, 2009, Dynamic activation of the anterior cingulate cortex during anticipatory anxiety, Neuroimage, 44, 975, 10.1016/j.neuroimage.2008.10.022 Pezawas, 2005, 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression, Nat Neurosci, 8, 828, 10.1038/nn1463 Kim, 2009, The structural integrity of an amygdala-prefrontal pathway predicts trait anxiety, J Neurosci, 29, 11614, 10.1523/JNEUROSCI.2335-09.2009 Kim MJ, Gee DG, Loucks RA, Davis FC, Whalen PJ. Anxiety dissociates dorsal and ventral medial prefrontal cortex functional connectivity with the amygdala at rest. Cereb Cortex. 2010; doi:10.1093/cercor/bhq237. 1992 Whalen, 2009 Amaral, 1992, Anatomical organization of the primate amygdaloid complex Freese, 2009, Neuroanatomy of the primate amygdala Aggleton, 1980, Cortical and subcortical afferents to the amygdala of the rhesus monkey (Macaca mulatta), Brain Res, 190, 347, 10.1016/0006-8993(80)90279-6 Carmichael, 1995, Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys, J. Comp. Neurol., 363, 615, 10.1002/cne.903630408 Ghashghaei, 2002, Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey, Neuroscience, 115, 1261, 10.1016/S0306-4522(02)00446-3 Ghashghaei, 2007, Sequence of information processing for emotions based on the anatomic dialogue between prefrontal cortex and amygdala, Neuroimage, 34, 905, 10.1016/j.neuroimage.2006.09.046 Leichnetz, 1976, The efferent projections of the medial prefrontal cortex in the squirrel monkey (Saimiri sciureus), Brain Res, 109, 455, 10.1016/0006-8993(76)90027-5 Stefanacci, 2002, Some observations on cortical inputs to the macaque monkey amygdala: an anterograde tracing study, J Comp Neurol, 451, 301, 10.1002/cne.10339 Amaral, 1984, Amygdalo-cortical projections in the monkey (Macaca fascicularis), J Comp Neurol, 230, 465, 10.1002/cne.902300402 Barbas, 1990, Projections from the amygdala to basoventral and mediodorsal prefrontal regions in the rhesus monkey, J Comp Neurol, 300, 549, 10.1002/cne.903000409 LeDoux, 1996 Mori, 1999, Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging, Ann Neurol, 45, 265, 10.1002/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3 Basser, 1996, Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI, J Magn Reson B, 111, 209, 10.1006/jmrb.1996.0086 Bracht, 2009, Extraction of prefronto-amygdalar pathways by combining probability maps, Psychiatry Res, 174, 217, 10.1016/j.pscychresns.2009.05.001 Croxson, 2005, Quantitative investigation of connections of the prefrontal cortex in the human and macaque using probabilistic diffusion tractography, J Neurosci, 25, 8854, 10.1523/JNEUROSCI.1311-05.2005 Johansen-Berg, 2008, Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression, Cereb Cortex, 18, 1374, 10.1093/cercor/bhm167 Friston, 1994, Functional and effective connectivity in neuroimaging: a synthesis, Hum Brain Mapp, 2, 56, 10.1002/hbm.460020107 McIntosh, 1994, Structural equation modeling and its application to network analysis in functional brain imaging, Hum Brain Mapp, 2, 2, 10.1002/hbm.460020104 Friston, 1997, Psychophysiological and modulatory interactions in neuroimaging, Neuroimage, 6, 218, 10.1006/nimg.1997.0291 Friston, 2003, Dynamic causal modelling, Neuroimage, 19, 1273, 10.1016/S1053-8119(03)00202-7 Banks, 2007, Amygdala-frontal connectivity during emotion regulation, Soc Cogn Affect Neurosci, 2, 303, 10.1093/scan/nsm029 Kim, 2003, Inverse amygdala and medial prefrontal cortex responses to surprised faces, Neuroreport, 14, 2317, 10.1097/00001756-200312190-00006 Kim, 2004, Contextual modulation of amygdala responsivity to surprised faces, J Cogn Neurosci, 16, 1730, 10.1162/0898929042947865 Biswal, 1995, Functional connectivity in the motor cortex of resting human brain using echo-planar MRI, Magn Reson Med, 34, 537, 10.1002/mrm.1910340409 Margulies, 2007, Mapping the functional connectivity of anterior cingulate cortex, Neuroimage, 37, 579, 10.1016/j.neuroimage.2007.05.019 Di Martino, 2008, Functional connectivity of human striatum: a resting state FMRI study, Cereb Cortex, 18, 2735, 10.1093/cercor/bhn041 Roy, 2009, Functional connectivity of the human amygdala using resting state fMRI, Neuroimage, 45, 614, 10.1016/j.neuroimage.2008.11.030 Wig, 2009, Repetition priming influences distinct brain systems: evidence from task-evoked data and resting-state correlations, J Neurophysiol, 101, 2632, 10.1152/jn.91213.2008 Kelly, 2008, Competition between functional brain networks mediates behavioral variability, Neuroimage, 39, 527, 10.1016/j.neuroimage.2007.08.008 Stevens, 2009, Correlated low-frequency BOLD fluctuations in the resting human brain are modulated by recent experience in category-preferential visual regions, Cereb Cortex Di Martino, 2009, Relationship between cingulo-insular functional connectivity and autistic traits in neurotypical adults, Am J Psychiatry, 166, 891, 10.1176/appi.ajp.2009.08121894 Davis, 2000, The amygdala, Curr Biol, 10, R131, 10.1016/S0960-9822(00)00345-6 Kapp, 1994, Stimulation of the amygdaloid central nucleus produces EEG arousal, Behav Neurosci, 108, 81, 10.1037/0735-7044.108.1.81 Holstege, 1996, The emotional motor system, Prog Brain Res, 107, 3, 10.1016/S0079-6123(08)61855-5 Davis, 2001, The amygdala: vigilance and emotion, Mol Psychiatry, 6, 13, 10.1038/sj.mp.4000812 LeDoux, 2000, Emotion circuits in the brain, Annu Rev Neurosci, 23, 155, 10.1146/annurev.neuro.23.1.155 Kim, 1992, Selective impairment of long-term but not short-term conditional fear by the N-methyl-d-aspartate antagonist APV, Behav Neurosci, 106, 591, 10.1037/0735-7044.106.4.591 Quirk, 1995, Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: parallel recordings in the freely behaving rat, Neuron, 15, 1029, 10.1016/0896-6273(95)90092-6 Fanselow, 1999, Why we think plasticity underlying Pavlovian fear conditioning occurs in the basolateral amygdala, Neuron, 23, 229, 10.1016/S0896-6273(00)80775-8 Rogan, 1997, Fear conditioning induces associative long-term potentiation in the amygdala, Nature, 390, 604, 10.1038/37601 Quirk, 2002, Memory for extinction of conditioned fear is long-lasting and persists following spontaneous recovery, Learn Mem, 9, 402, 10.1101/lm.49602 Rescorla, 2001, Retraining of extinguished Pavlovian stimuli, J Exp Psychol Anim Behav Process, 27, 115, 10.1037/0097-7403.27.2.115 Milad, 2002, Neurons in medial prefrontal cortex signal memory for fear extinction, Nature, 420, 70, 10.1038/nature01138 Hartley CA, Fischl B, Phelps EA. Brain structure correlates of individual differences in the acquisition and inhibition of conditioned fear. Cereb Cortex. doi:10.1093/cercor/bhq253. Milad, 2005, Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memory, Proc Natl Acad Sci USA, 102, 10706, 10.1073/pnas.0502441102 Delgado, 2008, Neural circuitry underlying the regulation of conditioned fear and its relation to extinction, Neuron, 59, 829, 10.1016/j.neuron.2008.06.029 Milad, 2007, Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert, Biol Psychiatry, 62, 446, 10.1016/j.biopsych.2006.10.011 Phelps, 2004, Extinction learning in humans: role of the amygdala and vmPFC, Neuron, 43, 897, 10.1016/j.neuron.2004.08.042 Hartley, 2010, Changing fear: the neurocircuitry of emotion regulation, Neuropsychopharmacology, 35, 136, 10.1038/npp.2009.121 Davidson, 2000, Dysfunction in the neural circuitry of emotion regulation—A possible prelude to violence, Science, 289, 591, 10.1126/science.289.5479.591 Hariri, 2000, Modulating emotional responses: effects of a neocortical network on the limbic system, Neuroreport, 11, 43, 10.1097/00001756-200001170-00009 Hariri, 2003, Neocortical modulation of the amygdala response to fearful stimuli, Biol Psychiatry, 53, 494, 10.1016/S0006-3223(02)01786-9 Lieberman, 2007, Putting feelings into words: affect labeling disrupts amygdala activity in response to affective stimuli, Psychol Sci, 18, 421, 10.1111/j.1467-9280.2007.01916.x Ochsner, 2002, Rethinking feelings: an FMRI study of the cognitive regulation of emotion, J Cogn Neurosci, 14, 1215, 10.1162/089892902760807212 Phan, 2005, Neural substrates for voluntary suppression of negative affect: a functional magnetic resonance imaging study, Biol Psychiatry, 57, 210, 10.1016/j.biopsych.2004.10.030 Erk, 2010, Acute and sustained effects of cognitive emotion regulation in major depression, J Neurosci, 30, 15726, 10.1523/JNEUROSCI.1856-10.2010 Urry, 2006, Amygdala and ventromedial prefrontal cortex are inversely coupled during regulation of negative affect and predict the diurnal pattern of cortisol secretion among older adults, J Neurosci, 26, 4415, 10.1523/JNEUROSCI.3215-05.2006 Wager, 2008, Prefrontal-subcortical pathways mediating successful emotion regulation, Neuron, 59, 1037, 10.1016/j.neuron.2008.09.006 Drabant, 2009, Individual differences in typical reappraisal use predict amygdala and prefrontal responses, Biol Psychiatry, 65, 367, 10.1016/j.biopsych.2008.09.007 Welborn, 2009, Variation in orbitofrontal cortex volume: relation to sex, emotion regulation and affect, Soc Cogn Affect Neurosci, 4, 328, 10.1093/scan/nsp028 Foland-Ross, 2010, Amygdala reactivity in healthy adults is correlated with prefrontal cortical thickness, J Neurosci, 30, 16673, 10.1523/JNEUROSCI.4578-09.2010 Botvinick, 1999, Conflict monitoring versus selection-for-action in anterior cingulate cortex, Nature, 402, 179, 10.1038/46035 Botvinick, 2004, Conflict monitoring and anterior cingulate cortex: an update, Trends Cogn Sci, 8, 539, 10.1016/j.tics.2004.10.003 Miller, 2001, An integrative theory of prefrontal cortex function, Annu Rev Neurosci, 24, 167, 10.1146/annurev.neuro.24.1.167 Cooney, 2007, Remembering the good times: neural correlates of affect regulation, Neuroreport, 18, 1771, 10.1097/WNR.0b013e3282f16db4 Heatherton, 2011, Cognitive neuroscience of self-regulation failure, Trends Cogn Sci, 15, 132, 10.1016/j.tics.2010.12.005 Adolphs, 1995, Fear and the human amygdala, J Neurosci, 15, 5879, 10.1523/JNEUROSCI.15-09-05879.1995 Breiter, 1996, Response and habituation of the human amygdala during visual processing of facial expression, Neuron, 17, 875, 10.1016/S0896-6273(00)80219-6 Hariri, 2002, Serotonin transporter genetic variation and the response of the human amygdala, Science, 297, 400, 10.1126/science.1071829 Kim, 2010, Behind the mask: the influence of mask-type on amygdala response to fearful faces, Soc Cogn Affect Neurosci, 5, 363, 10.1093/scan/nsq014 Morris, 1996, A differential neural response in the human amygdala to fearful and happy facial expressions, Nature, 383, 812, 10.1038/383812a0 Whalen, 1998, Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge, J Neurosci, 18, 411, 10.1523/JNEUROSCI.18-01-00411.1998 Whalen, 2001, A functional MRI study of human amygdala responses to facial expressions of fear versus anger, Emotion, 1, 70, 10.1037/1528-3542.1.1.70 Fusar-Poli, 2009, Functional atlas of emotional faces processing: a voxel-based meta-analysis of 105 functional magnetic resonance imaging studies, J Psychiatry Neurosci, 34, 418 Fitzgerald, 2006, Beyond threat: amygdala reactivity across multiple expressions of facial affect, Neuroimage, 30, 1441, 10.1016/j.neuroimage.2005.11.003 Whalen, 1998, Fear, vigilance, and ambiguity: initial neuroimaging studies of the human amygdala, Curr Dir Psychol Sci, 7, 177, 10.1111/1467-8721.ep10836912 Adolphs, 1994, Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala, Lett Nat, 372, 669, 10.1038/372669a0 Neta, 2009, Corrugator muscle responses are associated with individual differences in positivity–negativity bias, Emotion, 9, 640, 10.1037/a0016819 Oler, 2009, Cinguloamygdala interactions in surprise and extinction: interpreting associative ambiguity Eysenck, 1992 Rosen, 1998, From normal fear to pathological anxiety, Psychol Rev, 105, 325, 10.1037/0033-295X.105.2.325 Hare, 2008, Biological substrates of emotional reactivity and regulation in adolescence during an emotional go-nogo task, Biol Psychiatry, 63, 927, 10.1016/j.biopsych.2008.03.015 Bishop, 2004, State anxiety modulation of the amygdala response to unattended threat-related stimuli, J Neurosci, 24, 10364, 10.1523/JNEUROSCI.2550-04.2004 Dickie, 2008, Amygdala responses to unattended fearful faces: interaction between sex and trait anxiety, Psychiatry Res, 162, 51, 10.1016/j.pscychresns.2007.08.002 Etkin, 2004, Individual differences in trait anxiety predict the response of the basolateral amygdala to unconsciously processed fearful faces, Neuron, 44, 1043, 10.1016/j.neuron.2004.12.006 Somerville, 2004, Human amygdala responses during presentation of happy and neutral faces: correlations with state anxiety, Biol Psychiatry, 55, 897, 10.1016/j.biopsych.2004.01.007 Stein, 2007, Increased amygdala and insula activation during emotion processing in anxiety-prone subjects, Am J Psychiatry, 164, 318, 10.1176/appi.ajp.164.2.318 Seeley, 2007, Dissociable intrinsic connectivity networks for salience processing and executive control, J Neurosci, 27, 2349, 10.1523/JNEUROSCI.5587-06.2007 Costa, 1997, Stability and change in personality assessment: the revised NEO Personality Inventory in the year 2000, J Pers Assess, 68, 86, 10.1207/s15327752jpa6801_7 Cremers, 2010, Neuroticism modulates amygdala-prefrontal connectivity in response to negative emotional facial expressions, Neuroimage, 49, 963, 10.1016/j.neuroimage.2009.08.023 Rauch, 2006, Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research – past, present, and future, Biol Psychiatry, 60, 376, 10.1016/j.biopsych.2006.06.004 Shin, 2009, Is posttraumatic stress disorder a stress-induced fear circuitry disorder?, J Trauma Stress, 10.1002/jts.20442 Kessler, 1994, Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey, Arch Gen Psychiatry, 51, 8, 10.1001/archpsyc.1994.03950010008002 APA, 1994 Clark, 2002, Information processing in social phobia, Biol Psychiatry, 51, 92, 10.1016/S0006-3223(01)01296-3 Rapee, 1997, A cognitive-behavioral model of anxiety in social phobia, Behav Res Ther, 35, 741, 10.1016/S0005-7967(97)00022-3 Goldin, 2009, Neural bases of social anxiety disorder: emotional reactivity and cognitive regulation during social and physical threat, Arch Gen Psychiatry, 66, 170, 10.1001/archgenpsychiatry.2008.525 Stein, 2002, Increased amygdala activation to angry and contemptuous faces in generalized social phobia, Arch Gen Psychiatry, 59, 1027, 10.1001/archpsyc.59.11.1027 Yoon, 2007, Amygdala reactivity to emotional faces at high and low intensity in generalized social phobia: a 4-Tesla functional MRI study, Psychiatry Res, 154, 93, 10.1016/j.pscychresns.2006.05.004 Cooney, 2006, Amygdala activation in the processing of neutral faces in social anxiety disorder: is neutral really neutral?, Psychiatry Res, 148, 55, 10.1016/j.pscychresns.2006.05.003 Shah, 2009, Amygdala and insula response to emotional images in patients with generalized social anxiety disorder, J Psychiatry Neurosci, 34, 296 Hahn, 2011, Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder, Neuroimage., 56, 881, 10.1016/j.neuroimage.2011.02.064 Phan, 2009, Preliminary evidence of white matter abnormality in the uncinate fasciculus in generalized social anxiety disorder, Biol Psychiatry, 66, 691, 10.1016/j.biopsych.2009.02.028 Ebeling, 1992, Topography of the uncinate fascicle and adjacent temporal fiber tracts, Acta Neurochir (Wien), 115, 143, 10.1007/BF01406373 Milad, 2009, Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder, Biol Psychiatry, 66, 1075, 10.1016/j.biopsych.2009.06.026 Kolassa, 2007, Altered oscillatory brain dynamics after repeated traumatic stress, BMC Psychiatry, 7, 56, 10.1186/1471-244X-7-56 Shin, 2005, A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder, Arch Gen Psychiatry, 62, 273, 10.1001/archpsyc.62.3.273 Kim, 2008, Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder, J Psychiatry Res, 42, 268, 10.1016/j.jpsychires.2007.02.003 Phan, 2006, Corticolimbic blood flow during nontraumatic emotional processing in posttraumatic stress disorder, Arch Gen Psychiatry, 63, 184, 10.1001/archpsyc.63.2.184 Gusnard, 2001, Searching for a baseline: functional imaging and the resting human brain, Nat Rev Neurosci, 2, 685, 10.1038/35094500 Lanius, 2010, Default mode network connectivity as a predictor of post-traumatic stress disorder symptom severity in acutely traumatized subjects, Acta Psychiatr Scand, 121, 33, 10.1111/j.1600-0447.2009.01391.x Kim, 2005, Disrupted white matter tract integrity of anterior cingulate in trauma survivors, Neuroreport, 16, 1049, 10.1097/00001756-200507130-00004 Kim, 2006, Asymmetrically altered integrity of cingulum bundle in posttraumatic stress disorder, Neuropsychobiology, 54, 120, 10.1159/000098262