Akutes Leberversagen
Tóm tắt
Das akute Leberversagen (ALV) ist ein seltenes, aber lebensbedrohliches Zustandsbild. Charakteristisch ist das rasche Auftreten eines schweren Leberschadens mit hepatozellulärer Nekrose und eingeschränkter Leberfunktion. Bei weiterhin hoher Mortalität ist ein frühzeitiges Erkennen und Einleiten einer ursachenspezifischen unterstützenden sowie v. a. intensivmedizinischen symptomatischen Therapie essenziell. Durch Fortschritte im Bereich der intensivmedizinischen Behandlung von Patienten mit akutem Leberversagen sowie der Lebertransplantation konnte das Überleben deutlich verbessert werden.
Tài liệu tham khảo
Trey C, Davidson CS (1970) The management of fulminant hepatic failure. Prog Liver Dis 3:282–298
Lee WM, Squires RH Jr., Nyberg SL, Doo E, Hoofnagle JH (2008) Acute liver failure: Summary of a workshop. Hepatology 47(4):1401–1415
O’Grady JG, Alexander GJ, Hayllar KM, Williams R (1989) Early indicators of prognosis in fulminant hepatic failure. Gastroenterology 97:439–445
Oketani M, Ido A, Nakayama N et al (2013) Etiology and prognosis of fulminant hepatitis and late-onset hepatic failure in Japan: Summary of the annual nationwide survey between 2004 and 2009. Hepatol Res 43(2):97–105
Ostapowicz G (2002) Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 137:947–954
Lidofsky SD (1993) Liver transplantation for fulminant hepatic failure. Gastroenterol Clin North Am 22(2):257–269
Denzer U, Helmreich-Becker I, Galle PR, Lohse AW (2003) Liver assessment and biopsy in patients with marked coagulopathy: value of mini-laparoscopy and control of bleeding. Am J Gastroenterol 98(4):893–900
Kalambokis G, Manousou P, Vibhakorn S et al (2007) Transjugular liver biopsy–indications, adequacy, quality of specimens, and complications–a systematic review. J Hepatol 47(2):284–294
Drolz A, Jäger B, Wewalka M et al (2013) Clinical impact of arterial ammonia levels in ICU patients with different liver diseases. Intensive Care Med 39(7):1227–1237
Bernal W, Hall C, Karvellas CJ, Auzinger G, Sizer E, Wendon J (2007) Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure. Hepatology 46(6):1844–1852
Gill RQ, Sterling RK (2001) Acute liver failure. J Clin Gastroenterol 33(3):191–198
Simpson KJ, Bates CM, Henderson NC et al (2009) The utilization of liver transplantation in the management of acute liver failure: comparison between acetaminophen and non-acetaminophen etiologies. Liver Transplant 15(6):600–609
O’Grady JG, Schalm SW, Williams R (1993) Acute liver failure: redefining the syndromes. Lancet 342(8866):273–275
Bernuau J, Rueff B, Benhamou JP (1986) Fulminant and subfulminant liver failure: definitions and causes. Semin Liver Dis 6(2):97–106
Bundesärztekammer (2013) Richtlinien zur Organtransplantation gem. §16 ABs. 1S. 1 Nrn. 2 u. 5 TPG. Dtsch Arztebl 110(6):A-241–A-242
Schmidt LE, Larsen FS (2007) MELD score as a predictor of liver failure and death in patients with acetaminophen-induced liver injury. Hepatology 45(3):789–796
Bernal W, Auzinger G, Dhawan A, Wendon J (2010) Acute liver failure. Lancet 376(9736):190–201
Hadem J, Tacke F, Bruns T et al (2012) Etiologies and outcomes of acute liver failure in Germany. Clin Gastroenterol Hepatol 10(6):664–669 e2
Hoofnagle JH, Nelson KE, Purcell RH (2012) Hepatitis E. N Engl J Med 367(13):1237–1244
Pischke S, Behrendt P, Bock CT, Jilg W, Manns MP, Wedemeyer H (2014) Hepatitis E in Germany–an under-reported infectious disease. Dtsch Arztebl Int 111(35–36):577–583
Manka P, Bechmann LP, Coombes JD et al (2015) Hepatitis E virus infection as a possible cause of acute liver failure in europe. Clin Gastroenterol Hepatol 13(10):1836–1842
Zhang J, Zhang XF, Huang SJ et al (2015) Long-term efficacy of a hepatitis E vaccine. N Engl J Med 372(10):914–922
Poethko-Muller C, Zimmermann R, Hamouda O et al (2013) Epidemiology of hepatitis A, B, and C among adults in Germany: results of the German Health Interview and Examination Survey for Adults (DEGS1). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56(5–6):707–715
Khuroo MS, Kamili S (2003) Aetiology and prognostic factors in acute liver failure in India. J Viral Hepat 10(3):224–231
Torres HA, Davila M (2012) Reactivation of hepatitis B virus and hepatitis C virus in patients with cancer. Nat Rev Clin Oncol 9(3):156–166
Perrillo RP, Martin P, Lok AS (2015) Preventing hepatitis B reactivation due to immunosuppressive drug treatments. JAMA 313(16):1617–1618
Schiodt FV, Davern TJ, Shakil AO, McGuire B, Samuel G, Lee WM (2003) Viral hepatitis-related acute liver failure. Am J Gastroenterol 98(2):448–453
Reuben A, Koch DG, Lee WM (2010) Drug-induced acute liver failure: Results of a U.S. multicenter, prospective study. Hepatology 52(6):2065–2076
Schiodt FV, Rochling FA, Casey DL, Lee WM (1997) Acetaminophen toxicity in an urban county hospital. N Engl J Med 337(16):1112–1117
Auzinger G, Wendon J (2008) Intensive care management of acute liver failure. Curr Opin Crit Care 14(2):179–188
U.S. National Library of Medicine. http://livertox.nih.gov/, Clinical and Research Information in Drug-Induced Liver Injury. Zugegriffen: 21. April 2016
Fuhrmann V, Jager B, Zubkova A, Drolz A (2010) Hypoxic hepatitis – epidemiology, pathophysiology and clinical management. Wien Klin Wochenschr 122(5–6):129–139
Drolz A, Horvatits T, Roedl K, Fuhrmann V (2014) Shock liver and cholestatic liver in critically ill patients. Med Klin Intensivmed Notfmed 109(4):228–234
Fuhrmann V, Kneidinger N, Herkner H et al (2011) Impact of hypoxic hepatitis on mortality in the intensive care unit. Intensive Care Med 37(8):1302–1310
Horvatits T, Trauner M, Fuhrmann V (2013) Hypoxic liver injury and cholestasis in critically ill patients. Curr Opin Crit Care 19(2):128–132
Jager B, Drolz A, Michl B et al (2012) Jaundice increases the rate of complications and one-year mortality in patients with hypoxic hepatitis. Hepatology 56(6):2297–2304
Fuhrmann V, Kneidinger N, Herkner H et al (2009) Hypoxic hepatitis: underlying conditions and risk factors for mortality in critically ill patients. Intensive Care Med 35(8):1397–1405
Fuhrmann V, Madl C, Mueller C et al (2006) Hepatopulmonary syndrome in patients with hypoxic hepatitis. Gastroenterology 131(1):69–75
Drolz A, Horvatits T, Michl B et al (2014) Statin therapy is associated with reduced incidence of hypoxic hepatitis in critically ill patients. J Hepatol 60(6):1187–1193
Ludwig J, Hashimoto E, McGill DB, van Heerden JA (1990) Classification of hepatic venous outflow obstruction: ambiguous terminology of the Budd-Chiari syndrome. Mayo Clin Proc 65(1):51–55
Seijo S, Plessier A, Hoekstra J et al (2013) Good long-term outcome of Budd-Chiari syndrome with a step-wise management. Hepatology 57(5):1962–1968
Lee WM (2008) Etiologies of acute liver failure. Semin Liver Dis 28:142–152
Stravitz RT, Kramer AH, Davern T et al (2007) Intensive care of patients with acute liver failure: recommendations of the U.S. Acute Liver Failure Study Group. Crit Care Med 35(11):2498–2508
EASL Clinical Practice Guidelines (2015) Autoimmune hepatitis. J Hepatol 63(4):971–1004
Bernal W, Hyyrylainen A, Gera A et al (2013) Lessons from look-back in acute liver failure? A single centre experience of 3300 patients. J Hepatol 59(1):74–80
Tujios SR, Hynan LS, Vazquez MA et al (2015) Risk factors and outcomes of acute kidney injury in patients with acute liver failure. Clin Gastroenterol Hepatol 13(2):352–359
Slack AJ, Auzinger G, Willars C et al (2014) Ammonia clearance with haemofiltration in adults with liver disease. Liver Int 34(1):42–48
Chevret L, Durand P, Lambert J et al (2014) High-volume hemofiltration in children with acute liver failure. Pediatr Crit Care Med 15(7):300–305
Kramer L, Tribl B, Gendo A et al (2000) Partial pressure of ammonia versus ammonia in hepatic encephalopathy. Hepatology 31(1):30–34
Acharya SK, Bhatia V, Sreenivas V, Khanal S, Panda SK (2009) Efficacy of L‑ornithine L‑aspartate in acute liver failure: a double-blind, randomized, placebo-controlled study. Gastroenterology 136(7):2159–2168
Singanayagam A, Bernal W (2015) Update on acute liver failure. Curr Opin Crit Care 21(2):134–141
Fuhrmann V, Horvatits T, Drolz A, Rutter K (2014) Extracorporeal therapy of patients with liver disease in the intensive care unit. Med Klin Intensivmed Notfmed 109(4):246–251
Hassanein TI, Tofteng F, Brown RS Jr. et al (2007) Randomized controlled study of extracorporeal albumin dialysis for hepatic encephalopathy in advanced cirrhosis. Hepatology 46(6):1853–1862
Saliba F, Camus C, Durand F et al (2013) Albumin dialysis with a noncell artificial liver support device in patients with acute liver failure: a randomized, controlled trial. Ann Intern Med 159(8):522–531
Al-Chalabi A, Matevossian E, Ak VT (2013) Evaluation of the Hepa Wash(R) treatment in pigs with acute liver failure. BMC Gastroenterol 13:83
Larsen FS, Schmidt LE, Bernsmeier C et al (2015) High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial. J Hepatol 64(1):69–78
Germani G, Theocharidou E, Adam R et al (2012) Liver transplantation for acute liver failure in Europe: outcomes over 20 years from the ELTR database. J Hepatol 57(2):288–296