Wei Tao1,2, Xiaoyuan Ji1,2,3, Xiaoding Xu1,2, Mohammad Ariful Islam1, Zhongjun Li4, Si Chen4, Phei Er Saw1, Han Zhang4, Zameer Bharwani1, Zilei Guo1, Jinjun Shi1, Omid C. Farokhzad1,5
1Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
2these authors contributed equally to this work
3University of Chinese Academy of Sciences, Beijing, 100049, China
4Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics, SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology, and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, China
5King Abdulaziz University, Jeddah 21589, Saudi Arabia
Tóm tắt
AbstractPhotothermal therapy (PTT) has shown significant potential for cancer therapy. However, developing nanomaterials (NMs)‐based photothermal agents (PTAs) with satisfactory photothermal conversion efficacy (PTCE) and biocompatibility remains a key challenge. Herein, a new generation of PTAs based on two‐dimensional (2D) antimonene quantum dots (AMQDs) was developed by a novel liquid exfoliation method. Surface modification of AMQDs with polyethylene glycol (PEG) significantly enhanced both biocompatibility and stability in physiological medium. The PEG‐coated AMQDs showed a PTCE of 45.5 %, which is higher than many other NMs‐based PTAs such as graphene, Au, MoS2, and black phosphorus (BP). The AMQDs‐based PTAs also exhibited a unique feature of NIR‐induced rapid degradability. Through both in vitro and in vivo studies, the PEG‐coated AMQDs demonstrated notable NIR‐induced tumor ablation ability. This work is expected to expand the utility of 2D antimonene (AM) to biomedical applications through the development of an entirely novel PTA platform.
