Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

European Heart Journal - Tập 38 Số 32 - Trang 2459-2472 - 2017
Brian A. Ference1, Henry N. Ginsberg2, Ian Graham3, Kausik K. Ray4,5, Chris J. Packard6, Éric Bruckert7, Robert A. Hegele8, Ronald M. Krauss9, Frederick J. Raal10, Heribert Schunkert11,12, Gerald F. Watts13, Jan Borén14,15, Sergio Fazio16, Jay D. Horton17,18, L. Masana19, Stephen J. Nicholls20, Børge G. Nordestgaard21,22,23, Bart van de Sluis24, Marja‐Riitta Taskinen25, Christian Weber26, Ulf Landmesser27,7,2, Ulrich Laufs28, Olov Wiklund29,30, Jane Stock31, M. John Chapman32, Alberico L. Catapano33
1Division of Translational Research and Clinical Epidemiology, Division of Cardiovascular Medicine, Wayne State University School of Medicine, Detroit, MI 48202, USA;
2Irving Institute for Clinical and Translational Research, Columbia University, New York, NY, USA;
3Trinity College, Dublin, Ireland
4Department of Primary Care and Public Health,
5Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, Imperial College, London, UK
6College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
7INSERM UMRS1166, Department of Endocrinology-Metabolism, ICAN - Institute of CardioMetabolism and Nutrition, AP-HP, Hôpital de la Pitié, Paris, France
8Department of Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada;
9Department of Atherosclerosis Research, Children’s Hospital Oakland Research Institute, Oakland, CA 94609, USA
10Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa
11Deutsches Herzzentrum München, Technische Universität München, Munich 80636, Germany
12Deutsches Zentrum für Herz und Kreislauferkrankungen (DZHK), Partner Site Munich Heart Alliance, Munich 81377, Germany
13Lipid Disorders Clinic, Centre for Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia;
14Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden
15University of Gothenburg, Gothenburg, Sweden
16Department of Medicine, Center for Preventive Cardiology of the Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA;
17Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
18Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
19Research Unit of Lipids and Atherosclerosis, University Rovira i Virgili, C. Sant Llorenç 21, Reus 43201, Spain
20South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia
21Department of Clinical Biochemistry and The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark;
22Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
23The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Denmark
24Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, Groningen AV 9713, The Netherlands;
25Helsinki University Central Hospital and Research Programs' Unit, Diabetes and Obesity, Heart and Lung Centre, University of Helsinki, Helsinki, Finland;
26Hacettepe University, Ankara, Turkey
27Department of Cardiology, Charité-Universitätsmedizin Berlin (CBF), Hindenburgdamm 30, Berlin 12203, Germany
28Klinik für Innere Medizin III (Kardiologie, Angiologie und Internistische Intensivmedizin), Universitätsklinikum des Saarlandes, Homburg/Saar, Germany
29Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden
30Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
31European Atherosclerosis Society, Gothenburg, Sweden
32INSERM, Dyslipidemia and Atherosclerosis Research, and University of Pierre and Marie Curie, Pitié-Sâlpetrière University Hospital, Paris, France
33Department of Pharmacological and Biomolecular Sciences, University of Milan and IRCCS Multimedica, Milan, Italy

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