Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy

Abbruzzese JL, Grunewald R, Weeks EA, Gravel D, Adams T, Nowak B, Mineishi S, Tarassoff P, Satterlee W and Raber MN . (1991). J. Clin. Oncol., 9, 491–498.

Acimovic Y and Coe IR . (2002). Mol. Biol. Evol., 19, 2199–2210.

Baker CH, Banzon J, Bollinger JM, Stubbe J, Samano V, Robins MJ, Lippert B, Jarvi E and Resvick R . (1991). J. Med. Chem., 34, 1879–1884.

Baldwin S, Beal P, Yao SYM, King AE, Cass CE and Young JD . (2003). Pflugers Arch., June 28 (Epub ahead of print).

Baldwin SA, Mackey JR, Cass CE and Young JD . (1999). Mol. Med. Today, 5, 216–224.

Belanger K, Moore M, Baker SD, Dionne J, Maclean M, Jolivet J, Siu L, Soulieres D, Wainman N and Seymour L . (2002). J. Clin. Oncol., 20, 2567–2574.

Belt JA, Harper EH, Byl JA and Noel LD . (1992). Proc. Am. Assoc. Cancer Res., 33, 20.

Belt JA, Marina NM, Phelps DA and Crawford CR . (1993). Adv. Enzyme Regul., 33, 235–252.

Blum JL, Jones SE, Buzdar AU, LoRusso PM, Kuter I, Vogel C, Osterwalder B, Burger HU, Brown CS and Griffin T . (1999). J. Clin. Oncol., 17, 485–493.

Brockman RW, Schabel Jr FM and Montgomery JA . (1977). Biochem. Pharmacol., 26, 2193–2196.

Brookes AJ . (1999). Gene, 234, 177–186.

Burris III HA, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, Cripps MC, Portenoy RK, Storniolo AM, Tarassoff P, Nelson R, Dorr FA, Stephens CD and Von Hoff DD . (1997). J. Clin. Oncol., 15, 2403–2413.

Cabrita MA, Baldwin SA, Young JD and Cass CE . (2002). Biochem. Cell Biol., 80, 623–638.

Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ and Lander ES . (1999). Nat. Genet., 22, 231–238.

Carson DA, Wasson DB, Esparza LM, Carrera CJ, Kipps TJ and Cottam HB . (1992). Proc. Natl. Acad. Sci. USA, 89, 2970–2974.

Cass CE . (1995). Drug transport in antimicrobial and anticancer chemotherapy Georgopapadakou NH (ed). Marcel Dekker: New York, pp. 403–451.

Cass CE, Young JD and Baldwin SA . (1998). Biochem. Cell Biol., 76, 761–770.

Cass CE, Young JD, Baldwin SA, Cabrita MA, Graham KA, Griffiths M, Jennings LL, Mackey JR, Ng AM, Ritzel MW, Vickers MF and Yao SY . (1999). Pharm. Biotechnol., 12, 313–352.

Catapano CV, Chandler KB and Fernandes DJ . (1991). Cancer Res., 51, 1829–1835.

Chandrasena G, Giltay R, Patil SD, Bakken A and Unadkat JD . (1997). Biochem. Pharmacol., 53, 1909–1918.

Chen R and Nelson JA . (2000). Biochem. Pharmacol., 60, 215–219.

Chen SF, Cleaveland JS, Hollmann AB, Wiemann MC, Parks Jr RE and Stoeckler JD . (1986). Cancer Res., 46, 3449–3455.

Chun HG, Leyland-Jones B and Cheson BD . (1991). J. Clin. Oncol., 9, 175–188.

Clarke ML, Mackey JR, Baldwin SA, Young JD and Cass CE . (2002). Cancer Treat. Res., 112, 27–47.

Coe I, Zhang Y, McKenzie T and Naydenova Z . (2002). FEBS Lett., 517, 201–205.

Coe IR, Griffiths M, Young JD, Baldwin SA and Cass CE . (1997). Genomics, 45, 459–460.

Crawford CR, Patel DH, Naeve C and Belt JA . (1998). J. Biol. Chem., 273, 5288–5293.

Damaraju S, Sawyer M and Zanke B (eds) (2002). Genomic Approaches to Clinical Drug Resistance. Kluwer Academic Publisher: MA, USA.

Danhauser L, Plunkett W, Keating M and Cabanillas F . (1986). Cancer Chemother. Pharmacol., 18, 145–152.

Delicado EG, Sen RP and Miras-Portugal MT . (1991). Biochem. J., 279 (Part 3), 651–655.

Dimopoulos MA, Kantarjian H, Weber D, O'Brien S, Estey E, Delasalle K, Rose E, Cabanillas F, Keating M and Alexanian R . (1994). J. Clin. Oncol., 12, 2694–2698.

Ecker G . (2002). Curr. Opin. Invest. Drugs, 3, 1533–1538.

Ellison RR, Carey RW and Holland JF . (1967). Clin. Pharmacol. Ther., 8, 800–809.

Ellison RR, Holland JF, Weil M, Jacquillat C, Boiron M, Bernard J, Sawitsky A, Rosner F, Gussoff B, Silver RT, Karanas A, Cuttner J, Spurr CL, Hayes DM, Blom J, Leone LA, Haurani F, Kyle R, Hutchison JL, Forcier RJ and Moon JH . (1968). Blood, 32, 507–523.

Fideu MD and Miras-Portugal MT . (1992). Neurochem. Res., 17, 1099–1104.

Fideu MD and Miras-Portugal MT . (1993). Cell Mol. Neurobiol., 13, 493–502.

Flanagan SA and Meckling-Gill KA . (1997). J. Biol. Chem., 272, 18026–18032.

Fram RJ, Egan EM and Kufe DW . (1983). Leuk. Res., 7, 243–249.

Furth JJ and Cohen SS . (1968). Cancer Res., 28, 2061–2067.

Galmarini CM, Thomas X, Calvo F, Rousselot P, Rabilloud M, El Jaffari A, Cros E and Dumontet C . (2002). Br. J. Haematol., 117, 860–868.

Gati WP, Paterson AR, Belch AR, Chlumecky V, Larratt LM, Mant MJ and Turner AR . (1998). Leuk. Lymphoma, 32, 45–54.

Genini D, Adachi S, Chao Q, Rose DW, Carrera CJ, Cottam HB, Carson DA and Leoni LM . (2000). Blood, 96, 3537–3543.

Giles FJ, Cortes JE, Baker SD, Thomas DA, O'Brien S, Smith TL, Beran M, Bivins C, Jolivet J and Kantarjian HM . (2001). J. Clin. Oncol., 19, 762–771.

Giles FJ, Faderl S, Thomas DA, Cortes JE, Garcia-Manero G, Douer D, Levine AM, Koller CA, Jeha SS, O'Brien SM, Estey EH and Kantarjian HM . (2003). J. Clin. Oncol., 21, 1050–1056.

Goh LB, Mack P and Lee CW . (1995). Anticancer Res., 15, 2575–2579.

Goldman ID . (2002). Clin. Cancer Res., 8, 4–6.

Gourdeau H, Clarke ML, Ouellet F, Mowles D, Selner M, Richard A, Lee N, Mackey JR, Young JD, Jolivet J, Lafreniere RG and Cass CE . (2001). Cancer Res., 61, 7217–7224.

Graham KA, Leithoff J, Coe IR, Mowles D, Mackey JR, Young JD and Cass CE . (2000). Nucleos. Nucleot. Nucl. Acids, 19, 415–434.

Gray JH, Owen RP, Urban TJ and Giacomini KM . (2003). Clin. Phramacol. Therap., 73, P59.

Griffith DA and Jarvis SM . (1996). Biochim. Biophys. Acta, 1286, 153–181.

Griffiths M, Beaumont N, Yao SY, Sundaram M, Boumah CE, Davies A, Kwong FY, Coe I, Cass CE, Young JD and Baldwin SA . (1997a). Nat. Med., 3, 89–93.

Griffiths M, Yao SY, Abidi F, Phillips SE, Cass CE, Young JD and Baldwin SA . (1997b). Biochem. J., 328 (Part 3), 739–743.

Grove KL and Cheng YC . (1996). Cancer Res., 56, 4187–4191.

Grove KL, Guo X, Liu SH, Gao Z, Chu CK and Cheng YC . (1995). Cancer Res., 55, 3008–3011.

Guida L, Bruzzone S, Sturla L, Franco L, Zocchi E and De Flora A . (2002). J. Biol. Chem., 277, 47097–47105.

Gutierrez MM, Brett CM, Ott RJ, Hui AC and Giacomini KM . (1992). Biochim. Biophys. Acta, 1105, 1–9.

Gutierrez MM and Giacomini KM . (1993). Biochim. Biophys. Acta, 1149, 202–208.

Gutierrez MM and Giacomini KM . (1994). Biochem. Pharmacol., 48, 2251–2253.

Hamajima N, Saito T, Matsuo K, Suzuki T, Nakamura T, Matsuura A, Okuma K and Tajima K . (2002). J. Epidemiol., 12, 229–236.

Handa M, Choi DS, Caldeiro RM, Messing RO, Gordon AS and Diamond I . (2001). Gene, 262, 301–307.

Hande KR and Chabner BA . (1978). Cancer Res., 38, 579–585.

Heinemann V, Hertel LW, Grindey GB and Plunkett W . (1988). Cancer Res., 48, 4024–4031.

Heinemann V, Xu YZ, Chubb S, Sen A, Hertel LW, Grindey GB and Plunkett W . (1992). Cancer Res., 52, 533–539.

Hoff PM, Ansari R, Batist G, Cox J, Kocha W, Kuperminc M, Maroun J, Walde D, Weaver C, Harrison E, Burger HU, Osterwalder B, Wong AO and Wong R . (2001). J. Clin. Oncol., 19, 2282–2292.

Huang M, Wang Y, Cogut SB, Mitchell BS and Graves LM . (2003). J. Pharmacol. Exp. Ther., 304, 753–760.

Huang P, Chubb S and Plunkett W . (1990). J. Biol. Chem., 265, 16617–16625.

Huang P and Plunkett W . (1991). Mol. Pharmacol., 39, 449–455.

Huang P and Plunkett W . (1995). Semin. Oncol., 22, 19–25.

Hyde RJ, Cass CE, Young JD and Baldwin SA . (2001). Mol. Membr. Biol., 18, 53–63.

Iida A, Saito S, Sekine A, Harigae S, Osawa S, Mishima C, Kondo K, Kitamura Y and Nakamura Y . (2001). J. Hum. Genet., 46, 590–594.

Illmer T, Schuler US, Thiede C, Schwarz UI, Kim RB, Gotthard S, Freund D, Schakel U, Ehninger G and Schaich M . (2002). Cancer Res., 62, 4955–4962.

Ishikawa T, Sekiguchi F, Fukase Y, Sawada N and Ishitsuka H . (1998). Cancer Res., 58, 685–690.

Jennings LL, Hao C, Cabrita MA, Vickers MF, Baldwin SA, Young JD and Cass CE . (2001). Neuropharmacology, 40, 722–731.

Jones KW, Rylett RJ and Hammond JR . (1994). Brain Res., 660, 104–112.

Kaye SB . (1998). Br. J. Cancer, 78 (Suppl. 3), 1–7.

Kichenin K, Pignede G, Fudalej F and Seman M . (2000). Eur. J. Immunol., 30, 366–370.

King KM and Cass CE . (1994). Proc. Am. Assoc. Cancer Res., 35, A3436.

King KM, Damaraju V, Mowles DA, Lang T, Vickers MF, Young JD and Cass CE . (2003). Proc. Am. Assoc. Cancer Res., 44, 1500.

Kiss A, Farah K, Kim J, Garriock RJ, Drysdale TA and Hammond JR . (2000). Biochem. J., 352 (Part 2), 363–372.

Kufe DW, Major PP, Egan EM and Beardsley GP . (1980). J. Biol. Chem., 255, 8997–8900.

Kwong FY, Wu JS, Shi MM, Fincham HE, Davies A, Henderson PJ, Baldwin SA and Young JD . (1993). J. Biol. Chem., 268, 22127–22134.

Lamont EB and Schilsky RL . (1999). Clin. Cancer Res., 5, 2289–2296.

Lang TT, Selner M, Young JD and Cass CE . (2001). Mol. Pharmacol., 60, 1143–1152.

Lassota P, Kazimierczuk Z and Darzynkiewicz Z . (1994). Arch. Immunol. Ther. Exp. (Warsz), 42, 17–23.

Lee CW . (1994). Biochem. J., 300 (Part 2), 407–412.

Lee CW, Sokoloski JA, Sartorelli AC and Handschumacher RE . (1991). Biochem. J., 274 (Part 1), 85–90.

Lindemalm S, Liliemark J, Gruber A, Eriksson S, Karlsson MO, Wang Y and Albertioni F . (2003). Haematologica, 88, 324–332.

Loewen SK, Ng AM, Yao SY, Cass CE, Baldwin SA and Young JD . (1999). J. Biol. Chem., 274, 24475–24484.

Lu X, Gong S, Monks A, Zaharevitz D and Moscow JA . (2002). J. Exp. Ther. Oncol., 2, 200–212.

Lum PY, Ngo LY, Bakken AH and Unadkat JD . (2000). Cancer Chemother. Pharmacol., 45, 273–278.

Mackey JR, Baldwin SA, Young JD and Cass CE . (1998a). Drug Resist. Update, 310–324.

Mackey JR, Jennings LL, Clarke ML, Santos CL, Dabbagh L, Vsianska M, Koski SL, Coupland RW, Baldwin SA, Young JD and Cass CE . (2002). Clin. Cancer Res., 8, 110–116.

Mackey JR, Mani RS, Selner M, Mowles D, Young JD, Belt JA, Crawford CR and Cass CE . (1998b). Cancer Res., 58, 4349–4357.

Mackey JR, Yao SY, Smith KM, Karpinski E, Baldwin SA, Cass CE and Young JD . (1999). J. Natl. Cancer Inst., 91, 1876–1881.

Mata JF, Garcia-Manteiga JM, Lostao MP, Fernandez-Veledo S, Guillen-Gomez E, Larrayoz IM, Lloberas J, Casado FJ and Pastor-Anglada M . (2001). Mol. Pharmacol., 59, 1542–1548.

Murray AW . (1971). Annu. Rev. Biochem., 40, 811–826.

Neff T and Blau CA . (1996). Exp. Hematol., 24, 1340–1346.

Ngo LY, Patil SD and Unadkat JD . (2001). Am. J. Physiol. Gastrointest. Liver Physiol., 280, G475–G481.

Osato DH, Huang CC, Kawamoto M, Johns SJ, Stryke D, Wang J, Ferrin TE, Herskowitz I and Giacomini KM . (2003). Pharmacogenetics, 13, 297–301.

Osses N, Pearson JD, Yudilevich DL and Jarvis SM . (1996). Biochem. J., 317 (Part 3), 843–848.

Owens JK, Shewach DS, Ullman B and Mitchell BS . (1992). Cancer Res., 52, 2389–2393.

Parker WB, Bapat AR, Shen JX, Townsend AJ and Cheng YC . (1988). Mol. Pharmacol., 34, 485–491.

Parker WB, Shaddix SC, Chang CH, White EL, Rose LM, Brockman RW, Shortnacy AT, Montgomery JA, Secrist III JA and Bennett Jr LL . (1991). Cancer Res., 51, 2386–2394.

Parker WB, Shaddix SC, Rose LM, Shewach DS, Hertel LW, Secrist III JA, Montgomery JA and Bennett Jr LL . (1999). Mol. Pharmacol., 55, 515–520.

Parodi J, Flores C, Aguayo C, Rudolph MI, Casanello P and Sobrevia L . (2002). Circ. Res., 90, 570–577.

Paterson AR, Gati WP, Vijayalakshmi D, Cass CE, Mant MJ, Young JD and Belch AR . (1993). Proc. Am. Assoc. Cancer Res., 34, A84.

Patil SD and Unadkat JD . (1997). Am. J. Physiol., 272, G1314–G1320.

Pennycooke M, Chaudary N, Shuralyova I, Zhang Y and Coe IR . (2001). Biochem. Biophys. Res. Commun., 280, 951–959.

Pettitt AR, Clarke AR, Cawley JC and Griffiths SD . (1999a). Br. J. Haematol., 105, 986–988.

Pettitt AR, Sherrington PD and Cawley JC . (1999b). Br. J. Haematol., 106, 1049–1051.

Plunkett W, Huang P, Xu YZ, Heinemann V, Grunewald R and Gandhi V . (1995). Semin. Oncol., 22, 3–10.

Possinger K . (1995). Anticancer Drugs, 6 (Suppl. 6), 55–59.

Ritzel MW, Ng AM, Yao SY, Graham K, Loewen SK, Smith KM, Hyde RJ, Karpinski E, Cass CE, Baldwin SA and Young JD . (2001a). Mol. Membr. Biol., 18, 65–72.

Ritzel MW, Ng AM, Yao SY, Graham K, Loewen SK, Smith KM, Ritzel RG, Mowles DA, Carpenter P, Chen XZ, Karpinski E, Hyde RJ, Baldwin SA, Cass CE and Young JD . (2001b). J. Biol. Chem., 276, 2914–2927.

Ritzel MW, Yao SY, Huang MY, Elliott JF, Cass CE and Young JD . (1997). Am. J. Physiol., 272, C707–C714.

Ritzel MW, Yao SY, Ng AM, Mackey JR, Cass CE and Young JD . (1998). Mol. Membr. Biol., 15, 203–211.

Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole CG, Coggill PC, Rice CM, Ning Z, Rogers J, Bentley DR, Kwok PY, Mardis ER, Yeh RT, Schultz B, Cook L, Davenport R, Dante M, Fulton L, Hillier L, Waterston RH, McPherson JD, Gilman B, Schaffner S, Van Etten WJ, Reich D, Higgins J, Daly MJ, Blumenstiel B, Baldwin J, Stange-Thomann N, Zody MC, Linton L, Lander ES and Altshuler D . (2001). Nature, 409, 928–933.

Sandoval A, Consoli U and Plunkett W . (1996). Clin. Cancer Res., 2, 1731–1741.

Sankar N, Machado J, Abdulla P, Hilliker AJ and Coe IR . (2002). Nucleic Acids Res., 30, 4339–4350.

Schachter JB, Yasuda RP and Wolfe BB . (1995). Cell Signal, 7, 659–668.

Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, Zhu J and Johnson DH . (2002). N. Engl. J. Med., 346, 92–98.

Schmoll HJ, Buchele T, Grothey A and Dempke W . (1999). Semin. Oncol., 26, 589–605.

SenGupta DJ, Lum PY, Lai Y, Shubochkina E, Bakken AH, Schneider G and Unadkat JD . (2002). Biochem., 41, 1512–1519.

Seymour JF, Kurzrock R, Freireich EJ and Estey EH . (1994). Blood, 83, 2906–2911.

Shryock JC and Belardinelli L . (1997). Am. J. Cardiol., 79, 2–10.

Sirotnak FM, Chello PL, Dorick DM and Montgomery JA . (1983). Cancer Res., 43, 104–109.

Sokoloski JA, Lee CW, Handschumacher RE, Nigam A and Sartorelli AC . (1991). Leuk. Res., 15, 1051–1058.

Soler C, Felipe A, Casado FJ, Celada A and Pastor-Anglada M . (2000). J. Leukocyte Biol., 67, 345–349.

Soler C, Felipe A, Mata JF, Casado FJ, Celada A and Pastor-Anglada M . (1998). J. Biol. Chem., 273, 26939–26945.

Soler C, Garcia-Manteiga J, Valdes R, Xaus J, Comalada M, Casado FJ, Pastor-Anglada M, Celada A and Felipe A . (2001a). FASEB J., 15, 1979–1988.

Soler C, Valdes R, Garcia-Manteiga J, Xaus J, Comalada M, Casado FJ, Modolell M, Nicholson B, MacLeod C, Felipe A, Celada A and Pastor-Anglada M . (2001b). J. Biol. Chem., 276, 30043–30049.

Stadler WM, Kuzel T, Roth B, Raghavan D and Dorr FA . (1997). J. Clin. Oncol., 15, 3394–3398.

Stam RW, den Boer ML, Meijerink JP, Ebus ME, Peters GJ, Noordhuis P, Janka-Schaub GE, Armstrong SA, Korsmeyer SJ and Pieters R . (2003). Blood, 101, 1270–1276.

Strohman R . (2002). Science, 296, 701–703.

Sundaram M, Yao SY, Ingram JC, Berry ZA, Abidi F, Cass CE, Baldwin SA and Young JD . (2001a). J. Biol. Chem., 276, 45270–45275.

Sundaram M, Yao SY, Ng AM, Cass CE, Baldwin SA and Young JD . (2001b). Biochemistry, 40, 8146–8151.

Sundaram M, Yao SYM, Ng AML, Griffiths M, Cass CE, Baldwin SA and Young JD . (1998). J. Biol. Chem., 273, 21519–21525.

Talbot DC, Moiseyenko V, Van Belle S, O'Reilly SM, Alba Conejo E, Ackland S, Eisenberg P, Melnychuk D, Pienkowski T, Burger HU, Laws S and Osterwalder B . (2002). Br. J. Cancer, 86, 1367–1372.

Townsley CA, Chi K, Ernst DS, Belanger K, Tannock I, Bjarnason GA, Stewart D, Goel R, Ruether JD, Siu LL, Jolivet J, McIntosh L, Seymour L and Moore MJ . (2003). J. Clin. Oncol., 21, 1524–1529.

Vickers MF, Kumar R, Visser F, Zhang J, Charania J, Raborn RT, Baldwin SA, Young JD and Cass CE . (2002). Biochem. Cell Biol., 80, 639–644.

Vickers MF, Young JD, Baldwin SA, Mackey JR and Cass CE . (2000). Emerging Therap. Targets, 4, 515–539.

Vijayalakshmi D and Belt JA . (1988). J. Biol. Chem., 263, 19419–19423.

Visser F, Vickers MF, Ng AM, Baldwin SA, Young JD and Cass CE . (2002). J. Biol. Chem., 277, 395–401.

von der Maase H, Hansen SW, Roberts JT, Dogliotti L, Oliver T, Moore MJ, Bodrogi I, Albers P, Knuth A, Lippert CM, Kerbrat P, Sanchez Rovira P, Wersall P, Cleall SP, Roychowdhury DF, Tomlin I, Visseren-Grul CM and Conte PF . (2000). J. Clin. Oncol., 18, 3068–3077.

Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB and Giacomini KM . (1997). Am. J. Physiol., 273, F1058–F1065.

Ward JL, Sherali A, Mo ZP and Tse CM . (2000). J. Biol. Chem., 275, 8375–8381.

Wijnholds J, Mol CA, van Deemter L, de Haas M, Scheffer GL, Baas F, Beijnen JH, Scheper RJ, Hatse S, De Clercq E, Balzarini J and Borst P . (2000). Proc. Natl. Acad. Sci. USA, 97, 7476–7481.

Wiley JS, Jones SP and Sawyer WH . (1983). Eur. J. Cancer Clin. Oncol., 19, 1067–1074.

Xie KC and Plunkett W . (1996). Cancer Res., 56, 3030–3037.

Yang SW, Huang P, Plunkett W, Becker FF and Chan JY . (1992). J. Biol. Chem., 267, 2345–2349.

Yao SY, Ng AM, Muzyka WR, Griffiths M, Cass CE, Baldwin SA and Young JD . (1997). J. Biol. Chem., 272, 28423–28430.

Yao SY, Ng AM, Sundaram M, Cass CE, Baldwin SA and Young JD . (2001). Mol. Membr. Biol., 18, 161–167.

Yao SY, Ng AM, Vickers MF, Sundaram M, Cass CE, Baldwin SA and Young JD . (2002). J. Biol. Chem., 277, 24938–24948.

Young JD, Cheeseman CI, Mackey JR, Cass CE and Baldwin SA . (2000). Gastrointestinal Transport, Molecular Physiology (Current Topics in Membranes, Vol. 50), Fambrough D, Benos D, Barrett K and Domowitz M. (eds). Academic Press: San Diego, CA, pp. 329–378.

Zimmerman TP, Mahony WB and Prus KL . (1987). J. Biol. Chem., 262, 5748–5754.