Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters

Aitken, 2006, Regulation of drug-metabolizing enzymes and transporters in inflammation, Annu Rev Pharmacol Toxicol, 46, 123, 10.1146/annurev.pharmtox.46.120604.141059 Blouin, 1999, Pharmacokinetic considerations in obesity, J Pharm Sci, 88, 1, 10.1021/js980173a Braun, 1998, Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats, Biochem J, 336, 587, 10.1042/bj3360587 Breslin, 2010, Weight gain in response to high-fat feeding in CD-1 male mice, Lab Anim, 44, 231, 10.1258/la.2010.009114 Cai, 2005, Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB, Nat Med, 11, 183, 10.1038/nm1166 Chen, 2003, Nuclear receptor, pregnane X receptor is required for induction of UDP-glucoronosyltransferases in mouse liver by pregnenolone-16 alpha-carbonitrile, Drug Metab Dispos, 31, 908, 10.1124/dmd.31.7.908 Chen, 2008, Effects of liver fibrosis on verapamil pharmacokinetics in rats, Clin Exp Pharmacol Physiol, 35, 287, 10.1111/j.1440-1681.2007.04826.x Cheng, 2008, Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity, Mol Pharm, 5, 77, 10.1021/mp700114j Cheymol, 2000, Effects of obesity on pharmacokinetics implications for drug therapy, Clin Pharmacokinet, 39, 215, 10.2165/00003088-200039030-00004 Chia, 2005, The origins and uses of mouse outbred stocks, Nat Genet, 37, 1181, 10.1038/ng1665 Collins, 2004, Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics, Physiol Behav, 81, 243, 10.1016/j.physbeh.2004.02.006 Ghose, 2004, Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: a novel mechanism for reduced hepatic gene expression in inflammation, Nucl Recept, 2, 4, 10.1186/1478-1336-2-4 Ghose, 2007, Rosiglitazone attenuates suppression of RXRalpha-dependent gene expression in inflamed liver, J Hepatol, 46, 115, 10.1016/j.jhep.2006.09.008 He, 2006, Factors influencing midazolam hydroxylation activity in human liver microsomes, Drug Metab Dispos, 34, 1198, 10.1124/dmd.105.008904 Hirosumi, 2002, A central role for JNK in obesity and insulin resistance, Nature, 420, 333, 10.1038/nature01137 Irizar, 1995, Defective expression of cytochrome P450 proteins in the liver of the genetically obese Zucker rat, Eur J Pharmacol, 293, 385, 10.1016/0926-6917(95)90059-4 Itoh, 2002, Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation, Mol Endocrinol, 16, 2382, 10.1210/me.2002-0144 Khemawoot, 2007, Obesity-induced increase of CYP2E1 activity and its effect on disposition kinetics of chlorzoxazone in Zucker rats, Biochem Pharmacol, 73, 155, 10.1016/j.bcp.2006.09.006 Kim, 2004, Hepatic gene expression profiles in a long-term high-fat diet-induced obesity mouse model, Gene, 340, 99, 10.1016/j.gene.2004.06.015 Leclercq, 2000, Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice, Biochem Biophys Res Commun, 268, 337, 10.1006/bbrc.2000.2125 Liang, 1996, Cyp1a2(−/−) null mutant mice develop normally but show deficient drug metabolism, Proc Natl Acad Sci U S A, 93, 1671, 10.1073/pnas.93.4.1671 Maglich, 2002, Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification, Mol Pharmacol, 62, 638, 10.1124/mol.62.3.638 Mangelsdorf, 1995, The RXR heterodimers and orphan receptors, Cell, 83, 841, 10.1016/0092-8674(95)90200-7 Mangelsdorf, 1995, The nuclear receptor superfamily: the second decade, Cell, 83, 835, 10.1016/0092-8674(95)90199-X McFarlin, 2009, Pomegranate seed oil consumption during a period of high-fat feeding reduces weight gain and reduces type 2 diabetes risk in CD-1 mice, Br J Nutr, 102, 54, 10.1017/S0007114508159001 Olkkola, 2008, Midazolam and other benzodiazepines, Handb Exp Pharmacol, 182, 335, 10.1007/978-3-540-74806-9_16 Osabe, 2008, Expression of hepatic UDP-glucuronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator-activated receptor alpha in male rats fed a high-fat and high-sucrose diet, Drug Metab Dispos, 36, 294, 10.1124/dmd.107.017731 Pascussi, 2000, Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes, Biochem Biophys Res Commun, 274, 707, 10.1006/bbrc.2000.3219 Pascussi, 2003, Pathophysiological factors affecting CAR gene expression, Drug Metab Rev, 35, 255, 10.1081/DMR-120026394 Ramadori, 2001, Cytokines in the liver, Eur J Gastroenterol Hepatol, 13, 777, 10.1097/00042737-200107000-00004 Rochette-Egly, 2003, Nuclear receptors: integration of multiple signalling pathways through phosphorylation, Cell Signal, 15, 355, 10.1016/S0898-6568(02)00115-8 Shoelson, 2006, Inflammation and insulin resistance, J Clin Invest, 116, 1793, 10.1172/JCI29069 Shoelson, 2007, Obesity, inflammation, and insulin resistance, Gastroenterology, 132, 2169, 10.1053/j.gastro.2007.03.059 Staudinger, 2008, Cell signaling and nuclear receptors: new opportunities for molecular pharmaceuticals in liver disease, Mol Pharm, 5, 17, 10.1021/mp700098c Surwit, 1988, Diet-induced type II diabetes in C57BL/6J mice, Diabetes, 37, 1163, 10.2337/diab.37.9.1163 Tan, 2004, A critical role for MAP kinases in the control of Ah receptor complex activity, Toxicol Sci, 82, 80, 10.1093/toxsci/kfh228 Teng, 2008, Regulation of transporters by nuclear hormone receptors: implications during inflammation, Mol Pharm, 5, 67, 10.1021/mp700102q Van Heek, 1997, Diet-induced obese mice develop peripheral, but not central, resistance to leptin, J Clin Invest, 99, 385, 10.1172/JCI119171 Wang, 2007, Mechanisms and outcomes of drug- and toxicant-induced liver toxicity in diabetes, Crit Rev Toxicol, 37, 413, 10.1080/10408440701215100 Wei, 2000, The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism, Nature, 407, 920, 10.1038/35038112 Wilkinson, 2005, Drug metabolism and variability among patients in drug response, N Engl J Med, 352, 2211, 10.1056/NEJMra032424 Yang, 1992, Dietary effects on cytochromes P450, xenobiotic metabolism, and toxicity, FASEB J, 6, 737, 10.1096/fasebj.6.2.1537464 Yoshinari, 2006, Hepatic CYP3A expression is attenuated in obese mice fed a high-fat diet, Pharm Res, 23, 1188, 10.1007/s11095-006-0071-6 Zimmerman, 2006, Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260, J Biol Chem, 281, 15434, 10.1074/jbc.M508277200