Cortical hypoperfusion and reduced cerebral metabolic rate of oxygen in the arcAβ mouse model of Alzheimer’s disease

Photoacoustics - Tập 10 - Trang 38-47 - 2018
Ruiqing Ni1, Markus Rudin1,2, Jan Klohs1
1Institute for Biomedical Engineering, University of Zurich & ETH Zurich, 8093 Zurich, Switzerland
2Institute of Pharmacology and Toxicology, University of Zurich, 8008 Zurich, Switzerland

Tài liệu tham khảo

Clarke, 1989, 565 Iadecola, 2004, Neurovascular regulation in the normal brain and in Alzheimer's disease, Nat. Rev. Neurosci., 5, 347, 10.1038/nrn1387 Hock, 1997, Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy (NIRS)–correlation with simultaneous rCBF-PET measurements, Brain Res., 755, 293, 10.1016/S0006-8993(97)00122-4 Iturria-Medina, 2016, Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis, Nat. Commun., 7, 11934, 10.1038/ncomms11934 Fukuyama, 1994, Altered cerebral energy metabolism in Alzheimer's disease: a PET study, J. Nucl. Med., 35, 1 Klohs, 2014, Imaging of cerebrovascular pathology in animal models of Alzheimer's disease, Front. Aging Neurosci., 6, 32, 10.3389/fnagi.2014.00032 Poisnel, 2012, Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease, Neurobiol. Aging, 33, 1995, 10.1016/j.neurobiolaging.2011.09.026 van Zijl, 1998, Quantitative assessment of blood flow, blood volume and blood oxygenation effects in functional magnetic resonance imaging, Nat. Med., 4, 159, 10.1038/nm0298-159 Temma, 2017, Sequential PET estimation of cerebral oxygen metabolism with spontaneous respiration of 15O-gas in mice with bilateral common carotid artery stenosis, J. Cereb. Blood Flow Metab., 10.1177/0271678X17692815 Christen, 2013, Imaging brain oxygenation with MRI using blood oxygenation approaches: methods, validation, and clinical applications, AJNR Am. J. Neuroradiol., 34, 1113, 10.3174/ajnr.A3070 Wise, 2013, Measurement of OEF and absolute CMRO2: MRI-based methods using interleaved and combined hypercapnia and hyperoxia, NeuroImage, 83, 135, 10.1016/j.neuroimage.2013.06.008 Klohs, 2013, Longitudinal assessment of amyloid pathology in transgenic ArcAbeta mice using multi-Parametric magnetic resonance imaging, PLoS One, 8, e66097, 10.1371/journal.pone.0066097 Klohs, 2016, Quantitative assessment of microvasculopathy in arcAbeta mice with USPIO-enhanced gradient echo MRI, J. Cereb. Blood Flow Metab., 36, 1614, 10.1177/0271678X15621500 Klohs, 2012, Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAbeta mice, J. Neurosci., 32, 1705, 10.1523/JNEUROSCI.5626-11.2012 Chong, 2015, Cerebral metabolic rate of oxygen (CMRO2) assessed by combined Doppler and spectroscopic OCT, Biomed. Opt. Express, 6, 3941, 10.1364/BOE.6.003941 Stern, 1977, Continuous measurement of tissue blood flow by laser-doppler spectroscopy, Am. J. Physiol., 232, H441 Sakadzic, 2010, Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue, Nat. Methods, 7, 755, 10.1038/nmeth.1490 Hallacoglu, 2012, Absolute measurement of cerebral optical coefficients, hemoglobin concentration and oxygen saturation in old and young adults with near-infrared spectroscopy, J. Biomed. Opt., 17, 10.1117/1.JBO.17.8.081406 Cao, 2017, Functional and oxygen-metabolic photoacoustic microscopy of the awake mouse brain, NeuroImage, 150, 77, 10.1016/j.neuroimage.2017.01.049 Yao, 2015, High-speed label-free functional photoacoustic microscopy of mouse brain in action, Nat. Methods, 12, 407, 10.1038/nmeth.3336 Li, 2017, Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution, Nat. Biomed. Eng., 1, 10.1038/s41551-017-0071 Razansky, 2007, Multispectral photoacoustic imaging of fluorochromes in small animals, Opt. Lett., 32, 2891, 10.1364/OL.32.002891 Weissleder, 2003, Shedding light onto live molecular targets, Nat. Med., 9, 123, 10.1038/nm0103-123 Merlini, 2011, Vascular beta-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAbeta mice, Acta Neuropathol. (Berl.), 122, 293, 10.1007/s00401-011-0834-y Taruttis, 2015, Advances in real-time multispectral optoacoustic imaging and its applications, Nat. Photon., 9, 219, 10.1038/nphoton.2015.29 Wang, 2013, Single-cell label-free photoacoustic flowoxigraphy in vivo, Proc. Natl. Acad. Sci. U. S. A., 110, 5759, 10.1073/pnas.1215578110 Knobloch, 2007, Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms, J. Neurosci., 27, 7648, 10.1523/JNEUROSCI.0395-07.2007 Vaas, 2017, Extracerebral tissue damage in the intraluminal filament mouse model of middle cerebral artery occlusion, Front. Neurol., 8, 85, 10.3389/fneur.2017.00085 Leithner, 2008, A flow sensitive alternating inversion recovery (FAIR)-MRI protocol to measure hemispheric cerebral blood flow in a mouse stroke model, Exp. Neurol., 210, 118, 10.1016/j.expneurol.2007.10.003 Zhang, 2013, In vivo blood T(1) measurements at 1.5T, 3T, and 7T, Magn. Reson. Med., 70, 1082, 10.1002/mrm.24550 Ni, 2018, Non-invasive detection of acute cerebral hypoxia and subsequent matrix-metalloproteinase activity in a mouse model of cerebral ischemia using multispectral-optoacoustic-tomography, Neurophotonics, 5, 10.1117/1.NPh.5.1.015005 Yao, 2014, Photoacoustic measurement of the Gruneisen parameter of tissue, J. Biomed. Opt., 19, 17007, 10.1117/1.JBO.19.1.017007 Tomaszewski, 2017, Oxygen enhanced optoacoustic tomography (OE-OT) reveals vascular dynamics in murine models of prostate cancer, Theranostics, 7, 2900, 10.7150/thno.19841 Xu, 2009, Noninvasive quantification of whole-brain cerebral metabolic rate of oxygen (CMRO2) by MRI, Magn. Reson. Med., 62, 141, 10.1002/mrm.21994 Li, 2008, Simultaneous molecular and hypoxia imaging of brain tumors in vivo using spectroscopic photoacoustic tomography, Proc. IEEE, 96, 481, 10.1109/JPROC.2007.913515 Yao, 2013, Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo, NeuroImage, 64, 257, 10.1016/j.neuroimage.2012.08.054 Gottschalk, 2015, Noninvasive real-time visualization of multiple cerebral hemodynamic parameters in whole mouse brains using five-dimensional optoacoustic tomography, J. Cereb. Blood Flow Metab., 35, 531, 10.1038/jcbfm.2014.249 Kidoguchi, 2006, In vivo X-ray angiography in the mouse brain using synchrotron radiation, Stroke, 37, 1856, 10.1161/01.STR.0000226904.96059.a6 Wang, 2006, Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography, J. Biomed. Opt., 11, 024015, 10.1117/1.2192804 Tzoumas, 2016, Eigenspectra optoacoustic tomography achieves quantitative blood oxygenation imaging deep in tissues, Nat. Commun., 7, 12121, 10.1038/ncomms12121 Sakadzic, 2014, Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue, Nat. Commun., 5, 5734, 10.1038/ncomms6734 van den Berg, 2015, Review of photoacoustic flow imaging: its current state and its promises, Photoacoustics, 3, 89, 10.1016/j.pacs.2015.08.001 Temma, 2008, PET O-15 cerebral blood flow and metabolism after acute stroke in spontaneously hypertensive rats, Brain Res., 1212, 18, 10.1016/j.brainres.2008.03.033 Cui, 2013, Non-invasive measurement of cerebral oxygen metabolism in the mouse brain by ultra-high field (17)O MR spectroscopy, J. Cereb. Blood Flow Metab., 33, 1846, 10.1038/jcbfm.2013.172 Zhu, 2013, Simultaneous and noninvasive imaging of cerebral oxygen metabolic rate, blood flow and oxygen extraction fraction in stroke mice, NeuroImage, 64, 437, 10.1016/j.neuroimage.2012.09.028 Takada, 1992, Age-related decline of cerebral oxygen metabolism in normal population detected with positron emission tomography, Neurol. Res., 14, 128, 10.1080/01616412.1992.11740031 De Vis, 2015, Age-related changes in brain hemodynamics; A calibrated MRI study, Hum. Brain Mapp., 36, 3973, 10.1002/hbm.22891 Delekate, 2014, Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer's disease mouse model, Nat. Commun., 5, 5422, 10.1038/ncomms6422 Maier, 2014, Longitudinal PET-MRI reveals beta-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion, Nat. Med., 20, 1485, 10.1038/nm.3734 Shin, 2007, Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy, Brain, 130, 2310, 10.1093/brain/awm156 Han, 2008, Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition, J. Neurosci., 28, 13542, 10.1523/JNEUROSCI.4686-08.2008 Li, 2014, Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow, Mol. Neurodegener., 9, 28, 10.1186/1750-1326-9-28 Princz-Kranz, 2010, Vascular response to acetazolamide decreases as a function of age in the arcA beta mouse model of cerebral amyloidosis, Neurobiol. Dis., 40, 284, 10.1016/j.nbd.2010.06.002 Eskildsen, 2017, Increased cortical capillary transit time heterogeneity in Alzheimer's disease: a DSC-MRI perfusion study, Neurobiol. Aging, 50, 107, 10.1016/j.neurobiolaging.2016.11.004 Nagata, 2000, Vascular and metabolic reserve in Alzheimer's disease, Neurobiol. Aging, 21, 301, 10.1016/S0197-4580(00)00130-5 Sun, 2006, Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression, Proc. Natl. Acad. Sci. U. S. A., 103, 18727, 10.1073/pnas.0606298103 Manohar, 2007, Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics, Opt. Express, 15, 12277, 10.1364/OE.15.012277 Knieling, 2017, Multispectral optoacoustic tomography for assessment of crohn's disease activity, N. Engl. J. Med., 376, 1292, 10.1056/NEJMc1612455 Stoffels, 2015, Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging, Sci. Transl. Med., 7, 10.1126/scitranslmed.aad1278