Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
Ping-Chih Ho1, Jessica Dauz Bihuniak2, Andrew N. Macintyre3, Matthew Staron1, Xiaojing Liu4, Robert Amezquita1,5, Yao-Chen Tsui1,6, Guoliang Cui1, Goran Micevic7, Jose C. Perales8, Steven H. Kleinstein5, E. Dale Abel9, Karl L. Insogna2, Stefan Feske10, Jason W. Locasale4, Marcus W. Bosenberg5,7, Jeffrey C. Rathmell3, Susan M. Kaech1
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA
2Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06519, USA
3Department of Pharmacology and Cancer Biology, Immunology, Duke Molecular Physiology Institute, Duke University, Durham, NC 27710, USA
4Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
5Department of Pathology, Yale University School of Medicine, New Haven, CT 06519, USA
6Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA
7Department of Dermatology, Yale University School of Medicine, New Haven, CT 06519, USA
8Biophysics Unit, Department of Physiological Sciences II, IDIBELL-University of Barcelona, Fexia Llarga s/n 08907, Spain
9Fraternal Order of Eagles Diabetes Research Center, Division of Endocrinology and Metabolism, Department of Medicine, Carver College of Medicine University of Iowa, Iowa City, IA 52242, USA
10Department of Pathology, New York University Langone Medical Center, New York, NY 10016, USA