Pain and major depressive disorder: Associations with cognitive impairment as measured by the THINC-integrated tool (THINC-it)

Scandinavian Journal of Pain - Tập 15 - Trang 62-67 - 2017
Danielle S. Cha1, Nicole E. Carmona1, Rodrigo B. Mansur1, Yena Lee1,2, Hyun Jung Park1, Nelson B. Rodrigues1, Mehala Subramaniapillai1, Joshua D. Rosenblat1,2, Zihang Pan1,2, Jae Hon Lee1,3, JungGoo Lee1,4, Fahad Almatham1, Asem Alageel1,5, Margarita Shekotikhina1, Aileen J. Zhou1, Carola Rong1,6, John Harrison7,8, Roger S. McIntyre1,2,9,10
1Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada
2Institute of Medical Science, University of Toronto, Toronto, ON, Canada
3Department of Psychiatry, Samsung Seoul Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea
4Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea
5Department of Psychiatry, College of Medicine, Imam University, Riyadh, Saudi Arabia
6American University of Integrative Sciences School of Medicine, Sint Maarten, The Netherlands
7Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands
8Metis Cognition Ltd., Warminster, UK
9Department of Psychiatry, University of Toronto, Toronto, ON, Canada
10Department of Pharmacology, University of Toronto, Toronto, ON, Canada

Tóm tắt

Abstract Objectives To examine the role of pain on cognitive function in adults with major depressive disorder (MDD). Methods Adults (18–65) with a Diagnostic and Statistical Manual – Fifth Edition (DSM-5)-defined diagnosis of MDD experiencing a current major depressive episode (MDE) were enrolled (nMDD = 100). All subjects with MDD were matched in age, sex, and years of education to healthy controls (HC) (nHC = 100) for comparison. Cognitive function was assessed using the recently validated THINC-integrated tool (THINC-it), which comprises variants of the choice reaction time (i.e., THINC-it: Spotter), One-Back (i.e., THINC-it: Symbol Check), Digit Symbol Substitution Test (i.e., THINC-it: Codebreaker), Trail Making Test – Part B (i.e., THINC-it: Trails), as well as the Perceived Deficits Questionnaire for Depression – 5-item (i.e., THINC-it: PDQ-5-D). A global index of objective cognitive function was computed using objective measures from the THINC-it, while self-rated cognitive deficits were measured using the PDQ-5-D. Pain was measured using a Visual Analogue Scale (VAS). Regression analyses evaluated the role of pain in predicting objective and subjective cognitive function. Results A significant between-group differences on the VAS was observed (p < 0.001), with individuals with MDD reporting higher pain severity as evidenced by higher scores on the VAS than HC. Significant interaction effects were observed between self -rated cognitive deficits and pain ratings (p < 0.001) on objective cognitive performance (after adjusting for MADRS total score), suggesting that pain moderates the association between self-rated and objective cognitive function. Conclusions Results indicated that pain is associated with increased self-rated and objective cognitive deficits in adults with MDD. Implications The study herein provides preliminary evidence demonstrating that adults with MDD reporting pain symptomatology and poorer subjective cognitive function is predictive of poorer objective cognitive performance. THINC-it is capable of detecting cognitive dysfunction amongst adults with MDD and pain.

Tài liệu tham khảo

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Scandinavian Journal of Pain

Tập 15

62-67

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