Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

Atarashi, 2008, ATP drives lamina propria T(H)17 cell differentiation, Nature, 455, 808, 10.1038/nature07240 Bäckhed, 2005, Host-bacterial mutualism in the human intestine, Science, 307, 1915, 10.1126/science.1104816 Bending, 2009, Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice, J. Clin. Invest., 119, 565, 10.1172/JCI37865 Benson, 2009, Gut commensal bacteria direct a protective immune response against Toxoplasma gondii, Cell Host Microbe, 6, 187, 10.1016/j.chom.2009.06.005 Binstadt, 2006, Particularities of the vasculature can promote the organ specificity of autoimmune attack, Nat. Immunol., 7, 284, 10.1038/ni1306 Björk, 1994, Role of the bowel flora for development of immunity to hsp 65 and arthritis in three experimental models, Scand. J. Immunol., 40, 648, 10.1111/j.1365-3083.1994.tb03518.x Chervonsky, 2010, Influence of microbial environment on autoimmunity, Nat. Immunol., 11, 28, 10.1038/ni.1801 Dalton, 1993, Multiple defects of immune cell function in mice with disrupted interferon-gamma genes, Science, 259, 1739, 10.1126/science.8456300 Devoss, 2008, Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1, J. Immunol., 181, 4072, 10.4049/jimmunol.181.6.4072 Duerkop, 2009, Immune responses to the microbiota at the intestinal mucosal surface, Immunity, 31, 368, 10.1016/j.immuni.2009.08.009 Edwards, 2008, Commensal gut bacteria and the etiopathogenesis of rheumatoid arthritis, J. Rheumatol., 35 Emamaullee, 2009, Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice, Diabetes, 58, 1302, 10.2337/db08-1113 Gaboriau-Routhiau, 2009, The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses, Immunity, 31, 677, 10.1016/j.immuni.2009.08.020 Garland, 1982, Segmented filamentous bacteria in the rodent small intestine: Their colonization of growing animals and possible role in host resistance to Salmonella, Microb. Ecol., 8, 181, 10.1007/BF02010451 Gray, 2007, Danger-free autoimmune disease in Aire-deficient mice, Proc. Natl. Acad. Sci. USA, 104, 18193, 10.1073/pnas.0709160104 Grice, 2009, Topographical and temporal diversity of the human skin microbiome, Science, 324, 1190, 10.1126/science.1171700 Harkiolaki, 2009, T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides, Immunity, 30, 348, 10.1016/j.immuni.2009.01.009 Hill, 2008, Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells, Immunity, 29, 758, 10.1016/j.immuni.2008.09.018 Hsu, 2008, Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice, Nat. Immunol., 9, 166, 10.1038/ni1552 Huang, 2010, Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis, Proc. Natl. Acad. Sci. USA, 107, 4658, 10.1073/pnas.1001074107 Ivanov, 2006, The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells, Cell, 126, 1121, 10.1016/j.cell.2006.07.035 Ivanov, 2008, Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine, Cell Host Microbe, 4, 337, 10.1016/j.chom.2008.09.009 Ivanov, 2009, Induction of intestinal Th17 cells by segmented filamentous bacteria, Cell, 139, 485, 10.1016/j.cell.2009.09.033 Jacobs, 2009, IL-17-producing T cells can augment autoantibody-induced arthritis, Proc. Natl. Acad. Sci. USA, 106, 21789, 10.1073/pnas.0912152106 Kelly, 2007, Importance of microbial colonization of the gut in early life to the development of immunity, Mutat. Res., 622, 58, 10.1016/j.mrfmmm.2007.03.011 Klaasen, 1992, Intestinal, segmented, filamentous bacteria, FEMS Microbiol. Rev., 8, 165, 10.1111/j.1574-6968.1992.tb04986.x Klaasen, 1993, Intestinal, segmented, filamentous bacteria in a wide range of vertebrate species, Lab. Anim., 27, 141, 10.1258/002367793780810441 Klaasen, 1993, Apathogenic, intestinal, segmented, filamentous bacteria stimulate the mucosal immune system of mice, Infect. Immun., 61, 303, 10.1128/IAI.61.1.303-306.1993 Korganow, 1999, From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins, Immunity, 10, 451, 10.1016/S1074-7613(00)80045-X Kouskoff, 1996, Organ-specific disease provoked by systemic autoimmunity, Cell, 87, 811, 10.1016/S0092-8674(00)81989-3 Ley, 2006, Ecological and evolutionary forces shaping microbial diversity in the human intestine, Cell, 124, 837, 10.1016/j.cell.2006.02.017 Ley, 2008, Evolution of mammals and their gut microbes, Science, 320, 1647, 10.1126/science.1155725 Ley, 2008, Worlds within worlds: evolution of the vertebrate gut microbiota, Nat. Rev. Microbiol., 6, 776, 10.1038/nrmicro1978 Maccioni, 2002, Arthritogenic monoclonal antibodies from K/BxN mice, J. Exp. Med., 195, 1071, 10.1084/jem.20011941 Macpherson, 2004, Interactions between commensal intestinal bacteria and the immune system, Nat. Rev. Immunol., 4, 478, 10.1038/nri1373 Macpherson, 2004, Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria, Science, 303, 1662, 10.1126/science.1091334 Martin-Orozco, 2009, Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells, Eur. J. Immunol., 39, 216, 10.1002/eji.200838475 Matsumoto, 1999, Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme, Science, 286, 1732, 10.1126/science.286.5445.1732 Matsumoto, 2002, How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease, Nat. Immunol., 3, 360, 10.1038/ni772 Mazmanian, 2006, The love-hate relationship between bacterial polysaccharides and the host immune system, Nat. Rev. Immunol., 6, 849, 10.1038/nri1956 Mazmanian, 2005, An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system, Cell, 122, 107, 10.1016/j.cell.2005.05.007 Mazmanian, 2008, A microbial symbiosis factor prevents intestinal inflammatory disease, Nature, 453, 620, 10.1038/nature07008 Niess, 2008, Commensal gut flora drives the expansion of proinflammatory CD4 T cells in the colonic lamina propria under normal and inflammatory conditions, J. Immunol., 180, 559, 10.4049/jimmunol.180.1.559 Nurieva, 2008, Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages, Immunity, 29, 138, 10.1016/j.immuni.2008.05.009 Pozzilli, 1993, NOD mouse colonies around the world—Recent facts and figures, Immunol. Today, 14, 193, 10.1016/0167-5699(93)90160-M Rakoff-Nahoum, 2008, Innate immune recognition of the indigenous microbial flora, Mucosal Immunol, 1, S10, 10.1038/mi.2008.49 Rakoff-Nahoum, 2004, Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis, Cell, 118, 229, 10.1016/j.cell.2004.07.002 Salzman, 2010, Enteric defensins are essential regulators of intestinal microbial ecology, Nat. Immunol., 11, 76, 10.1038/ni.1825 Sigmundsdottir, 2008, Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking, Nat. Immunol., 9, 981, 10.1038/ni.f.208 Snel, 1995, Comparison of 16S rRNA sequences of segmented filamentous bacteria isolated from mice, rats, and chickens and proposal of “Candidatus Arthromitus”, Int. J. Syst. Bacteriol., 45, 780, 10.1099/00207713-45-4-780 Stepankova, 2007, Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells, Inflamm. Bowel Dis., 13, 1202, 10.1002/ibd.20221 Stone, 2003, Should tetracycline treatment be used more extensively for rheumatoid arthritis? Metaanalysis demonstrates clinical benefit with reduction in disease activity, J. Rheumatol., 30, 2112 Strachan, 1989, Hay fever, hygiene, and household size, BMJ, 299, 1259, 10.1136/bmj.299.6710.1259 Talham, 1999, Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system, Infect. Immun., 67, 1992, 10.1128/IAI.67.4.1992-2000.1999 Umesaki, 1995, Segmented filamentous bacteria are indigenous intestinal bacteria that activate intraepithelial lymphocytes and induce MHC class II molecules and fucosyl asialo GM1 glycolipids on the small intestinal epithelial cells in the ex-germ-free mouse, Microbiol. Immunol., 39, 555, 10.1111/j.1348-0421.1995.tb02242.x Vaahtovuo, 2008, Fecal microbiota in early rheumatoid arthritis, J. Rheumatol., 35, 1500 Vassallo, 2008, Neonatal microbial flora and disease outcome, Nestle Nutr. Workshop Ser. Pediatr. Program., 61, 211, 10.1159/000113496 Voedisch, 2009, Mesenteric lymph nodes confine dendritic cell-mediated dissemination of Salmonella enterica serovar Typhimurium and limit systemic disease in mice, Infect. Immun., 77, 3170, 10.1128/IAI.00272-09 Wills-Karp, 2001, The germless theory of allergic disease: Revisiting the hygiene hypothesis, Nat. Rev. Immunol., 1, 69, 10.1038/35095579 Wu, 2007, Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk, J. Exp. Med., 204, 1911, 10.1084/jem.20070285 Ye, 2001, Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense, J. Exp. Med., 194, 519, 10.1084/jem.194.4.519 Yoshitomi, 2005, A role for fungal beta-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice, J. Exp. Med., 201, 949, 10.1084/jem.20041758