An LC/MS/MS method for simultaneous quantitation of two homoisoflavones: Protosappanin B and brazilin with hypoglycemic activity in rat plasma and its application to a comparative pharmacokinetic study in normal and streptozotocin-treated rats

Journal of Ethnopharmacology - Tập 148 - Trang 682-690 - 2013
Xiao-Zhe Tong1, Hui Zhu2, Yan Shi2, Hai-Tao Xu3, Biao Wang4, Jiu-Han Zhao5
1Department of Traditional Chinese Medicine, the First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, China
2Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China
3Jinzhou Central Hospital, Jinzhou 121000, China
4Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, China Medical University, Shenyang 110001, China
5Department of Neurology, the First Affiliated Hospital of China Medical University, Shenyang, 110001, China