Polyethylenimine with acid-labile linkages as a biodegradable gene carrier

Anderson, 1998, Human gene therapy, Nature, 392, 25, 10.1038/32801 Han, 2000, Development of biomaterials for gene therapy, Molec. Ther., 2, 302, 10.1006/mthe.2000.0142 Boussif, 1995, A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine, Proc. Natl. Acad. Sci. U. S. A., 92, 7297, 10.1073/pnas.92.16.7297 Godbey, 1999, Poly(ethylenimine) and its role in gene delivery, J. Control Release, 60, 149, 10.1016/S0168-3659(99)00090-5 Kunath, 2003, Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine, J. Control Release, 89, 113, 10.1016/S0168-3659(03)00076-2 Godbey, 1999, Size matters: molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle, J. Biomed. Mater. Res., 45, 268, 10.1002/(SICI)1097-4636(19990605)45:3<268::AID-JBM15>3.0.CO;2-Q Fischer, 1999, A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity, Pharm. Res., 16, 1273, 10.1023/A:1014861900478 Ahn, 2002, Biodegradable poly(ethyleneimine) for plasmid DNA delivery, J. Control Release, 80, 273, 10.1016/S0168-3659(01)00547-8 Forrest, 2003, A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery, Bioconjug. Chem., 14, 934, 10.1021/bc034014g Gosselin, 2001, Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine, Bioconjug. Chem., 12, 989, 10.1021/bc0100455 Armarego, 1996 Harpe, 2000, Characterization of commercially available and synthesized polyethylenimines for gene delivery, J. Control Release, 69, 309, 10.1016/S0168-3659(00)00317-5 Lee, 2003, Water soluble lipopolymer as an efficient carrier for gene delivery to myocardium, Gene Ther., 10, 585, 10.1038/sj.gt.3301938 Lee, 2001, Cell type specific and glucose responsive expression of interleukin-4 by using insulin promoter and water soluble lipopolymer, J. Control Release, 75, 421, 10.1016/S0168-3659(01)00416-3 Moret, 2001, Stability of PEI-DNA and DOTAP-DNA complexes: effect of alkaline pH, heparin and serum, J. Control. Release, 76, 169, 10.1016/S0168-3659(01)00415-1 Fisher, 2002, Copolymer of ethylene imine and N-(2-Hydroxyethyl)-ethylene imine as tools to study effects of polymer structure on physicochemical and biological properties of DNA complexes, Bioconjug. Chem., 13, 1124, 10.1021/bc025550w Han, 1992, Polynucleotide analogues: 3.1. Synthesis, characterization, and physicochemical properties of poly(thymidy1ic acid) analogues, Macromolecules, 25, 3534, 10.1021/ma00039a035 Godbey, 1999, Improved packing of poly(ethyleneimine)/DNA complexes increases transfection efficiency, Gene Ther., 6, 1380, 10.1038/sj.gt.3300976 Godbey, 2001, Poly(ethyleneimine)-mediated gene delivery affects endothelial cell function and viability, Biomaterials, 22, 471, 10.1016/S0142-9612(00)00203-9 Fischer, 1999, A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity, Pharm. Res., 16, 1273, 10.1023/A:1014861900478