Deposits in artificial corneas: risk factors and prevention

Clinical and Experimental Ophthalmology - Tập 32 Số 2 - Trang 185-191 - 2004
Celia R. Hicks1, Traian V. Chirilă1, Liliana Werner2, Geoffrey J. Crawford1, David J. Apple2, Ian J. Constable1
1Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Australia
2Intermountain Ocular Research Center, John A Moran Eye Center, University of Utah, Salt Lake City, USA

Tóm tắt

Abstract Purpose: To identify risk factors for calcium deposition and pigmented staining within AlphaCor artificial corneas. Methods: Retrospective analysis of data from 72 AlphaCor implantations was conducted. Histological analysis of explants was performed. Results: Eight cases of either intraoptic calcium or pigment deposition occurred in AlphaCor patients between 2.5 and 21 months after implantation. Four cases had diffuse white deposits, confirmed to be calcium and associated with prior coadministration of topical steroids and beta‐blockers. The other four cases had brown deposits, associated with cigarette smoking and topical levobunolol. Conclusion: These findings led to changes in patient management protocols, surgeon training and patient information so as to minimize the risk of further occurrences. No further cases of white deposition have occurred after warning surgeons of the risk associated with certain topical therapy combinations. The risk of brown staining may be difficult to remove completely as it appears that environmental exposure to chemicals may cause deposition in addition to personal smoking habits and topical medications.

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Tài liệu tham khảo

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Clinical and Experimental Ophthalmology

Tập 32 Số 2

185-191

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