Development and characterization of self-assembling nanoparticles using a bio-inspired amphipathic peptide for gene delivery

Baumhover, 2010, Synthesis and in vitro testing of new potent polyacridine-melittin gene delivery peptides, Bioconjug. Chem., 21, 74, 10.1021/bc9003124 Morris, 1997, A new peptide vector for efficient delivery of oligonucleotides into mammalian cells, Nucleic Acids Res., 25, 2730, 10.1093/nar/25.14.2730 Morris, 1999, A novel potent strategy for gene delivery using a single peptide vector as a carrier, Nucleic Acids Res., 27, 3510, 10.1093/nar/27.17.3510 Crombez, 2009, Targeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growth, Nucleic Acids Res., 37, 4559, 10.1093/nar/gkp451 Li, 2004, GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery, Adv. Drug Deliv. Rev., 23, 967, 10.1016/j.addr.2003.10.041 Subbarao, 1987, pH-dependent bilayer destabilization by an amphipathic peptide, Biochemistry, 26, 2964, 10.1021/bi00385a002 Nouri, 2013, A recombinant biopolymeric platform for reliable evaluation of the activity of pH-responsive amphiphile fusogenic peptides, Biomacromolecules, 14, 2033, 10.1021/bm400380s Karjoo, 2013, Systematic engineering of uniform, highly efficient, targeted and shielded viral-mimetic nanoparticles, Small, 9, 2774, 10.1002/smll.201300077 Simoes, 1998, Gene delivery by negatively charged ternary complexes of DNA, cationic liposomes and transferrin or fusogenic peptides, Gene Ther., 5, 955, 10.1038/sj.gt.3300674 Simoes, 1999, Transfection of human macrophages by lipoplexes via the combined use of transferrin and pH-sensitive peptides, J. Leukocyte Biol., 65, 270, 10.1002/jlb.65.2.270 Simoes, 1999, Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or pH-sensitive peptides, Gene Ther., 6, 1798, 10.1038/sj.gt.3301015 Wyman, 1997, Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers, Biochemistry, 36, 3008, 10.1021/bi9618474 Parente, 1990, Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA, Biochemistry, 29, 8720, 10.1021/bi00489a031 Erazo-Oliveras, 2012, Improving the endosomal escape of cell-penetrating peptides and their cargos: strategies and challenges, Pharmaceuticals (Basel), 5, 1177, 10.3390/ph5111177 Lee, 2001, A new gene delivery formulation of polyethylenimine/DNA complexes coated with PEG conjugated fusogenic peptides, J. Control. Release, 76, 183, 10.1016/S0168-3659(01)00426-6 Shaheen, 2011, KALA-modified multi-layered nanoparticles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine, Biomaterials, 32, 6342, 10.1016/j.biomaterials.2011.05.014 Fominaya, 2000, An optimized amphiphilic cationic peptide as an efficient non-viral gene delivery vector, J. Gene Med., 2, 455, 10.1002/1521-2254(200011/12)2:6<455::AID-JGM145>3.0.CO;2-O Emi, 1997, Gene transfer mediated by polyarginine requires a formation of big carrier-complex of DNA aggregate, Biochem. Biophys. Res. Commun., 231, 421, 10.1006/bbrc.1997.6125 Leventis, 2010, The distribution and function of phosphatidylserine in cellular membranes, Annu. Rev. Biophys., 39, 407, 10.1146/annurev.biophys.093008.131234 Luo, 2012, Arginine functionalized peptide dendrimers as potential gene delivery vehicles, Biomaterials, 33, 4917, 10.1016/j.biomaterials.2012.03.030 Khalil, 2011, Octaarginine- and pH sensitive fusogenic peptide-modified nanoparticles for liver gene delivery, J. Control. Release, 156, 374, 10.1016/j.jconrel.2011.08.012 Endoh, 2009, Cellular isRNA delivery using cell-penetrating peptides modified for endosomal escape, Adv. Drug Deliv. Rev., 61, 704, 10.1016/j.addr.2009.04.005 Jiang, 2011, Gene delivery to tumor cells by cationic polymeric nanovectors coupled to folic acid and the cell-penetrating peptide octaarginine, Biomaterials, 32, 7253, 10.1016/j.biomaterials.2011.06.015 Nam, 2012, Erythropoietin gene delivery using an arginine-grafted bioreducible polymer system, J. Control. Release, 157, 437, 10.1016/j.jconrel.2011.10.014 Tiera, 2011, Polycation-based gene therapy: current knowledge and new perspectives, Curr. Gene Ther., 11, 288, 10.2174/156652311796150408 McCarthy, 2010, Advances with the use of bio-inspired vectors towards creation of artificial viruses, Expert Opin. Drug Deliv., 7, 497, 10.1517/17425240903579989 Viola, 2010, Non-viral nanovectors for gene delivery: factors that govern successful therapeutics, Expert Opin. Drug Deliv., 7, 721, 10.1517/17425241003716810 Jiang, 2008, Nanoparticle-mediated cellular response is size-dependent, Nat. Nanotechnol., 3, 145, 10.1038/nnano.2008.30 De Smedt, 2000, Cationic polymer based gene delivery systems, Pharm. Res., 17, 113, 10.1023/A:1007548826495 Bagwe, 2006, Surface modification of silica nanoparticles to reduce aggregation and nonspecific binding, Langmuir, 22, 4357, 10.1021/la052797j Murray, 2001, Enhanced cationic liposome-mediated transfection using the DNA-binding peptide mu (mu) from the adenovirus core, Gene Ther., 8, 453, 10.1038/sj.gt.3301401 Malim, 1989, Functional dissection of the HIV-1 Rev trans-activator–derivation of a trans-dominant repressor of Rev function, Cell, 58, 205, 10.1016/0092-8674(89)90416-9 Cahill, 2009, Molecular electroporation and the transduction of oligoarginines, Phys. Biol., 11, 16001, 10.1088/1478-3975/7/1/016001 Tünnemann, 2008, Live-cell analysis of cell penetration ability and toxicity of oligo-arginines, J. Pept. Sci., 14, 469, 10.1002/psc.968 Mäger, 2010, Assessing the uptake kinetics and internalization mechanisms of cell-penetrating peptides using a quenched fluorescence assay, Biochim. Biophys. Acta, 1798, 333 Madani, 2011, Mechanisms of cellular uptake of cell-penetrating peptides, J. Biophys., 414729 Yang, 2012, Biodistribution studies of nanoparticles using fluorescence imaging: a qualitative or quantitative method?, Pharm. Res., 29, 3273, 10.1007/s11095-012-0818-1