Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)

Hepatology International - Tập 3 - Trang 269-282 - 2008
Shiv Kumar Sarin1, Ashish Kumar2, John A. Almeida3, Yogesh Kumar Chawla4, Sheung Tat Fan5, Hitendra Garg1, H. Janaka de Silva6, Saeed Sadiq Hamid7, Rajiv Jalan8, Piyawat Komolmit9, George K. Lau10, Qing Liu11, Kaushal Madan2, Rosmawati Mohamed12, Qin Ning13, Salimur Rahman14, Archana Rastogi15, Stephen M. Riordan3, Puja Sakhuja16, Didier Samuel17, Samir Shah18, Barjesh Chander Sharma1, Praveen Sharma1, Yasuhiro Takikawa19, Babu Ram Thapa20, Chun-Tao Wai21, Man-Fung Yuen10
1Department of Gastroenterology, G B Pant Hospital, Affiliated to University of Delhi, New Delhi, India
2Department of Hepatology, Institute of Liver & Biliary Sciences (ILBS), New Delhi, India
3Gastrointestinal and Liver Unit, The Prince of Wales Hospital and University of New South Wales, New South Wales, Australia
4Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
5Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
6Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
7Section of Gastroenterology, Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan
8The University College London (UCL) Institute of Hepatology, Division of Medicine, University College London, London, UK
9Department of Medicine, Faculty and Medicine, Chulalongkorn University, Bangkok , Thailand
10Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
11Beijing Youan Hospital, Capital University of Medical Sciences, Beijing, China
12Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
13Laboratory of Infectious Immunology, Department of Infectious Disease, Institute of Immunology, Huazhong University of Science and Technology, Wuhan, China
14Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
15Department of Pathology, Institute of Liver & Biliary Sciences (ILBS), New Delhi, India
16Department of Pathology, G. B. Pant Hospital, Affiliated to University of Delhi, New Delhi, India
17INSERM Unité 785, AP-HP Hôpital Paul Brousse, Villejuif, France
18Department of Gastroenterology, Jaslok Hospital and Research Center, Mumbai, India
19Department of Gastroenterology and Hepatology, Iwate Medical University, Morioka, Japan
20Division of Pediatric Gastroenterology, Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
21Asian Center for Liver Diseases and Transplantation, Gleneagles Hospital, Singapore, Singapore

Tóm tắt

The Asian Pacific Association for the Study of the Liver (APASL) set up a working party on acute-on-chronic liver failure (ACLF) in 2004, with a mandate to develop consensus guidelines on various aspects of ACLF relevant to disease patterns and clinical practice in the Asia-Pacific region. Experts predominantly from the Asia–Pacific region constituted this working party and were requested to identify different issues of ACLF and develop the consensus guidelines. A 2-day meeting of the working party was held on January 22–23, 2008, at New Delhi, India, to discuss and finalize the consensus statements. Only those statements that were unanimously approved by the experts were accepted. These statements were circulated to all the experts and subsequently presented at the Annual Conference of the APASL at Seoul, Korea, in March 2008. The consensus statements along with relevant background information are presented in this review.

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