The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study

Gatz, 2006, Role of genes and environments for explaining Alzheimer disease, Arch Gen Psychiatry, 63, 168, 10.1001/archpsyc.63.2.168 Saunders, 1993, Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease, Neurology, 43, 1467, 10.1212/WNL.43.8.1467 Farrer, 1997, Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium, JAMA, 278, 1349, 10.1001/jama.1997.03550160069041 Genin, 2011, APOE and Alzheimer disease: a major gene with semi-dominant inheritance, Mol Psychiatry, 16, 903, 10.1038/mp.2011.52 Seshadri, 1995, Apolipoprotein E epsilon 4 allele and the lifetime risk of Alzheimer's disease. What physicians know, and what they should know, Arch Neurol, 52, 1074, 10.1001/archneur.1995.00540350068018 Moulder, 2013, Dominantly Inherited Alzheimer Network: facilitating research and clinical trials, Alzheimers Res Ther, 5, 48, 10.1186/alzrt213 Reiman, 2011, Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments, J Alzheimers Dis, 26, 321, 10.3233/JAD-2011-0059 Jack, 2013, Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers, Lancet Neurol, 12, 207, 10.1016/S1474-4422(12)70291-0 Lambert, 2009, Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease, Nat Genet, 41, 1094, 10.1038/ng.439 Hollingworth, 2011, Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease, Nat Genet, 43, 429, 10.1038/ng.803 Lambert, 2013, Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease, Nat Genet, 45, 1452, 10.1038/ng.2802 Guerreiro, 2013, TREM2 variants in Alzheimer's disease, N Engl J Med, 368, 117, 10.1056/NEJMoa1211851 Naj, 2011, Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease, Nat Genet, 43, 436, 10.1038/ng.801 Desikan, 2015, Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer disease, Circulation, 131, 2061, 10.1161/CIRCULATIONAHA.115.015489 Jun, 2016, A novel Alzheimer disease locus located near the gene encoding tau protein, Mol Psychiatry, 21, 108, 10.1038/mp.2015.23 Seshadri, 2010, Genome-wide analysis of genetic loci associated with Alzheimer disease, JAMA, 303, 1832, 10.1001/jama.2010.574 Jonsson, 2013, Variant of TREM2 associated with the risk of Alzheimer's disease, N Engl J Med, 368, 107, 10.1056/NEJMoa1211103 Ruiz, 2014, Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia, Neurobiol Aging, 35, 444.e1, 10.1016/j.neurobiolaging.2013.08.011 Harold, 2009, Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, Nat Genet, 41, 1088, 10.1038/ng.440 Sleegers, 2015, A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Abeta42, Alzheimers Dement, 11, 1452, 10.1016/j.jalz.2015.02.013 Chouraki, 2016, Evaluation of a genetic risk score to improve risk prediction for Alzheimer's disease, J Alzheimers Dis, 53, 921, 10.3233/JAD-150749 Escott-Price, 2015, Common polygenic variation enhances risk prediction for Alzheimer's disease, Brain, 138, 3673, 10.1093/brain/awv268 Desikan, 2017, Genetic assessment of age-associated Alzheimer disease risk: development and validation of a polygenic hazard score, PLoS Med, 14, e1002258, 10.1371/journal.pmed.1002258 Rodriguez-Rodriguez, 2013, Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease, J Neural Transm (Vienna), 120, 807, 10.1007/s00702-012-0920-x Adams, 2015, Genetic risk of neurodegenerative diseases is associated with mild cognitive impairment and conversion to dementia, Alzheimers Dement, 11, 1277, 10.1016/j.jalz.2014.12.008 Lacour, 2017, Genome-wide significant risk factors for Alzheimer's disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment, Mol Psychiatry, 22, 153, 10.1038/mp.2016.18 Seshadri, 1997, Lifetime risk of dementia and Alzheimer's disease. The impact of mortality on risk estimates in the Framingham Study, Neurology, 49, 1498, 10.1212/WNL.49.6.1498 Wolters, 2017, Parental family history of dementia in relation to subclinical brain disease and dementia risk, Neurology, 88, 1642, 10.1212/WNL.0000000000003871 Ikram, 2017, The Rotterdam Study: 2018 update on objectives, design and main results, Eur J Epidemiol, 32, 807, 10.1007/s10654-017-0321-4 de Bruijn, 2015, The potential for prevention of dementia across two decades: the prospective, population-based Rotterdam Study, BMC Med, 13, 132, 10.1186/s12916-015-0377-5 Schrijvers, 2012, Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study, Neurology, 78, 1456, 10.1212/WNL.0b013e3182553be6 van Leeuwen, 2015, Population-specific genotype imputations using minimac or IMPUTE2, Nat Protoc, 10, 1285, 10.1038/nprot.2015.077 McCarthy, 2016, A reference panel of 64,976 haplotypes for genotype imputation, Nat Genet, 48, 1279, 10.1038/ng.3643 Allignol, 2011, Empirical transition matrix of multi-state models: the etm package, J Stat Softw, 38, 1, 10.18637/jss.v038.i04 Meister, 2008, Statistical methods for estimating the probability of spontaneous abortion in observational studies—analyzing pregnancies exposed to coumarin derivatives, Reprod Toxicol, 26, 31, 10.1016/j.reprotox.2008.06.006 Kaplan, 1958, Nonparametric estimation from incomplete observations, J Am Stat Assoc, 53, 457, 10.1080/01621459.1958.10501452 Tsai, 1987, A Note on the product-limit estimator under right censoring and left truncation, Biometrika, 74, 883, 10.1093/biomet/74.4.883 2016, 2016 Alzheimer's disease facts and figures, Alzheimers Dement, 12, 459, 10.1016/j.jalz.2016.03.001 Seshadri, 2007, Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study, Lancet Neurol, 6, 1106, 10.1016/S1474-4422(07)70291-0 McDaid, 2017, Bayesian association scan reveals loci associated with human lifespan and linked biomarkers, Nat Commun, 8, 15842, 10.1038/ncomms15842 Galea, 2007, Participation rates in epidemiologic studies, Ann Epidemiol, 17, 643, 10.1016/j.annepidem.2007.03.013 Marden, 2016, Using an Alzheimer disease polygenic risk score to predict memory decline in black and white Americans over 14 years of follow-up, Alzheimer Dis Assoc Disord, 30, 195, 10.1097/WAD.0000000000000137 2015, Convergent genetic and expression data implicate immunity in Alzheimer's disease, Alzheimers Dement, 11, 658, 10.1016/j.jalz.2014.05.1757 Liu, 2013, Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy, Nat Rev Neurol, 9, 106, 10.1038/nrneurol.2012.263 Myers, 1996, Apolipoprotein E epsilon4 association with dementia in a population-based study: the Framingham study, Neurology, 46, 673, 10.1212/WNL.46.3.673 Bickeboller, 1997, Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex, Am J Hum Genet, 60, 439 Cupples, 2004, Estimating risk curves for first-degree relatives of patients with Alzheimer's disease: the REVEAL study, Genet Med, 6, 192, 10.1097/01.GIM.0000132679.92238.58 Seshadri, 2006, The lifetime risk of stroke: estimates from the Framingham Study, Stroke, 37, 345, 10.1161/01.STR.0000199613.38911.b2 Bras, 2014, Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies, Hum Mol Genet, 23, 6139, 10.1093/hmg/ddu334 Khan, 2013, Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals, Int J Epidemiol, 42, 475, 10.1093/ije/dyt034 Guerreiro, 2016, Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases, Neurobiol Aging, 38, 214.e7, 10.1016/j.neurobiolaging.2015.10.028 Naj, 2014, Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study, JAMA Neurol, 71, 1394, 10.1001/jamaneurol.2014.1491