Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

Brazma, 2001, Minimum information about a microarray experiment (MIAME)-toward standards for microarray data, Nat. Genet., 29, 365, 10.1038/ng1201-365

Broderick, 2013, Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis, J. Clin. Immunol., 33, 162, 10.1007/s10875-012-9767-z

Chalkiadaki, 2012, High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction, Cell Metab., 16, 180, 10.1016/j.cmet.2012.07.003

Claesson, 2012, Gut microbiota composition correlates with diet and health in the elderly, Nature, 488, 178, 10.1038/nature11319

Creely, 2007, Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes, Am. J. Physiol. Endocrinol. Metab., 292, E740, 10.1152/ajpendo.00302.2006

Cutler, 2004, Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer’s disease, Proc. Natl. Acad. Sci. USA, 101, 2070, 10.1073/pnas.0305799101

Czirr, 2012, The immunology of neurodegeneration, J. Clin. Invest., 122, 1156, 10.1172/JCI58656

Dinarello, 2009, Immunological and inflammatory functions of the interleukin-1 family, Annu. Rev. Immunol., 27, 519, 10.1146/annurev.immunol.021908.132612

Duewell, 2010, NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals, Nature, 464, 1357, 10.1038/nature08938

Edgar, 2002, Gene Expression Omnibus: NCBI gene expression and hybridization array data repository, Nucleic Acids Res., 30, 207, 10.1093/nar/30.1.207

Ferrucci, 2005, The origins of age-related proinflammatory state, Blood, 105, 2294, 10.1182/blood-2004-07-2599

Franceschi, 2000, Inflamm-aging. An evolutionary perspective on immunosenescence, Ann. N Y Acad. Sci., 908, 244, 10.1111/j.1749-6632.2000.tb06651.x

Franceschi, 2007, Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans, Mech. Ageing Dev., 128, 92, 10.1016/j.mad.2006.11.016

Frisardi, 2010, Metabolic-cognitive syndrome: a cross-talk between metabolic syndrome and Alzheimer’s disease, Ageing Res. Rev., 9, 399, 10.1016/j.arr.2010.04.007

Goronzy, 2005, T cell development and receptor diversity during aging, Curr. Opin. Immunol., 17, 468, 10.1016/j.coi.2005.07.020

Goto, 2008, Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?, Biosci Trends, 2, 218

Green, 2011, Mitochondria and the autophagy-inflammation-cell death axis in organismal aging, Science, 333, 1109, 10.1126/science.1201940

Henao-Mejia, 2012, Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity, Nature, 482, 179, 10.1038/nature10809

Heneka, 2013, NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice, Nature, 493, 674, 10.1038/nature11729

Ippagunta, 2011, The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization, Nat. Immunol., 12, 1010, 10.1038/ni.2095

Kayagaki, 2011, Non-canonical inflammasome activation targets caspase-11, Nature, 479, 117, 10.1038/nature10558

Kayagaki, 2013, Noncanonical inflammasome activation by intracellular LPS independent of TLR4, Science, 341, 1246, 10.1126/science.1240248

Kotas, 2013, Role of caspase-1 in regulation of triglyceride metabolism, Proc. Natl. Acad. Sci. USA, 110, 4810, 10.1073/pnas.1301996110

Lamming, 2012, Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity, Science, 335, 1638, 10.1126/science.1215135

Lumeng, 2011, Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue, J. Immunol., 187, 6208, 10.4049/jimmunol.1102188

Mariathasan, 2006, Cryopyrin activates the inflammasome in response to toxins and ATP, Nature, 440, 228, 10.1038/nature04515

Martinon, 2006, Gout-associated uric acid crystals activate the NALP3 inflammasome, Nature, 440, 237, 10.1038/nature04516

Martinon, 2009, The inflammasomes: guardians of the body, Annu. Rev. Immunol., 27, 229, 10.1146/annurev.immunol.021908.132715

Masters, 2010, Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes, Nat. Immunol., 11, 897, 10.1038/ni.1935

McGillicuddy, 2011, Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis, Diabetes, 60, 1688, 10.2337/db10-1278

Miller, 2011, Preservation of femoral bone thickness in middle age predicts survival in genetically heterogeneous mice, Aging Cell, 10, 383, 10.1111/j.1474-9726.2011.00671.x

Morgan, 1999, The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction, Neuroscience, 89, 687, 10.1016/S0306-4522(98)00334-0

Naito, 2012, Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes, Cell, 149, 1298, 10.1016/j.cell.2012.03.047

Neff, 2013, Rapamycin extends murine lifespan but has limited effects on aging, J. Clin. Invest., 123, 3272, 10.1172/JCI67674

Netea, 2006, Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance, Nat. Med., 12, 650, 10.1038/nm1415

Okin, 2012, Evolution of inflammatory diseases, Curr. Biol., 22, R733, 10.1016/j.cub.2012.07.029

Pistell, 2012, Age-associated learning and memory deficits in two mouse versions of the Stone T-maze, Neurobiol. Aging, 33, 2431, 10.1016/j.neurobiolaging.2011.12.004

Ransohoff, 2012, Innate immunity in the central nervous system, J. Clin. Invest., 122, 1164, 10.1172/JCI58644

Ruggiero, 2006, Uric acid and inflammatory markers, Eur. Heart J., 27, 1174, 10.1093/eurheartj/ehi879

Shao, 2007, The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock, J. Biol. Chem., 282, 36321, 10.1074/jbc.M708182200

Stienstra, 2011, Inflammasome is a central player in the induction of obesity and insulin resistance, Proc. Natl. Acad. Sci. USA, 108, 15324, 10.1073/pnas.1100255108

Strowig, 2012, Inflammasomes in health and disease, Nature, 481, 278, 10.1038/nature10759

Vandanmagsar, 2011, The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance, Nat. Med., 17, 179, 10.1038/nm.2279

Wang, 1998, Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE, Cell, 92, 501, 10.1016/S0092-8674(00)80943-5

Wen, 2011, Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling, Nat. Immunol., 12, 408, 10.1038/ni.2022

Youm, 2011, Elimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damage, Endocrinology, 152, 4039, 10.1210/en.2011-1326

Youm, 2012, The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence, Cell Rep, 1, 56, 10.1016/j.celrep.2011.11.005