Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

The Lancet - Tập 397 - Trang 99-111 - 2021
Merryn Voysey1, Sue Ann Costa Clemens2,3, Shabir A Madhi4, Lily Y Weckx5, Pedro M Folegatti6, Parvinder K Aley1, Brian Angus6, Vicky L Baillie7, Shaun L Barnabas8, Qasim E Bhorat9, Sagida Bibi1, Carmen Briner10, Paola Cicconi6, Andrea M Collins11, Rachel Colin-Jones1, Clare L Cutland7, Thomas C Darton12,13, Keertan Dheda14,15, Christopher J A Duncan16,17, Katherine R W Emary1
1Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK
2Institute of Global Health, University of Siena, Siena, Brazil
3Department of Paediatrics, University of Oxford, Oxford, UK
4MRC Vaccines and Infectious Diseases Analytics Research Unit, Johannesburg, South Africa
5Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil
6Jenner Institute, Nuffield Department of Medicine, University of Oxford, UK
7Respiratory and Meningeal Pathogens Research Unit, University of the Witwatersrand, Johannesburg, South Africa
8Family Centre for Research with Ubuntu, Department of Paediatrics, University of Stellenbosch, Cape Town, South Africa
9Soweto Clinical Trials Centre, Soweto, South Africa
10Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
11Department of Clinical Sciences, Liverpool School of Tropical Medicine and Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK
12Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK
13Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
14Division of Pulmonology, Groote Schuur Hospital and the University of Cape Town, South Africa
15Faculty of Infectious and Tropical Diseases, Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, UK
16Department of Infection and Tropical Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
17Translational and Clinical Research Institute, Immunity and Inflammation Theme, Newcastle University, Newcastle upon Tyne, UK

Tài liệu tham khảo

Zhou, 2020, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet, 395, 1054, 10.1016/S0140-6736(20)30566-3 Stringhini, 2020, Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study, Lancet, 396, 313, 10.1016/S0140-6736(20)31304-0 Folegatti, 2020, Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial, Lancet, 396, 467, 10.1016/S0140-6736(20)31604-4 Ramasamy, 2020, Safety and immunogenicity of ChAdOx1 nCoV-19 (AZD1222) vaccine administered in a prime-boost regimen in older adults (COV002): a phase 2/3 single blind, randomised controlled trial, Lancet, 10.1016/S0140-6736(20)32466-1 Barret JR, Belij-Rammerstorfer S. Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses. Nat Med (in press). Marshall, 2020, A minimal common outcome measure set for COVID-19 clinical research, Lancet Infect Dis, 20, e192, 10.1016/S1473-3099(20)30483-7 Zou, 2004, A modified Poisson regression approach to prospective studies with binary data, Am J Epidemiol, 159, 702, 10.1093/aje/kwh090 Pace, 2015, Immunogenicity of reduced dose priming schedules of serogroup C meningococcal conjugate vaccine followed by booster at 12 months in infants: open label randomised controlled trial, BMJ, 350, 10.1136/bmj.h1554 Bartsch, 2020, Vaccine efficacy needed for a COVID-19 coronavirus vaccine to prevent or stop an epidemic as the sole intervention, Am J Prev Med, 59, 493, 10.1016/j.amepre.2020.06.011 Richards-Belle, 2020, COVID-19 in critical care: epidemiology of the first epidemic wave across England, Wales and Northern Ireland, Intensive Care Med, 46, 2035, 10.1007/s00134-020-06267-0 Sze, 2020, Ethnicity and clinical outcomes in COVID-19: a systematic Review and Meta-analysis, EClinicalMedicine, 10.1016/j.eclinm.2020.100630
Thông tin
Thông tin xuất bản

The Lancet

Tập 397

99-111

Thông tin tác giả