Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

The Lancet - Tập 397 - Trang 99-111 - 2021
Merryn Voysey1, Sue Ann Costa Clemens2,3, Shabir A Madhi4, Lily Y Weckx5, Pedro M Folegatti6, Parvinder K Aley1, Brian Angus6, Vicky L Baillie7, Shaun L Barnabas8, Qasim E Bhorat9, Sagida Bibi1, Carmen Briner10, Paola Cicconi6, Andrea M Collins11, Rachel Colin-Jones1, Clare L Cutland7, Thomas C Darton12,13, Keertan Dheda14,15, Christopher J A Duncan16,17, Katherine R W Emary1
1Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK
2Institute of Global Health, University of Siena, Siena, Brazil
3Department of Paediatrics, University of Oxford, Oxford, UK
4MRC Vaccines and Infectious Diseases Analytics Research Unit, Johannesburg, South Africa
5Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil
6Jenner Institute, Nuffield Department of Medicine, University of Oxford, UK
7Respiratory and Meningeal Pathogens Research Unit, University of the Witwatersrand, Johannesburg, South Africa
8Family Centre for Research with Ubuntu, Department of Paediatrics, University of Stellenbosch, Cape Town, South Africa
9Soweto Clinical Trials Centre, Soweto, South Africa
10Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
11Department of Clinical Sciences, Liverpool School of Tropical Medicine and Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK
12Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK
13Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
14Division of Pulmonology, Groote Schuur Hospital and the University of Cape Town, South Africa
15Faculty of Infectious and Tropical Diseases, Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, UK
16Department of Infection and Tropical Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
17Translational and Clinical Research Institute, Immunity and Inflammation Theme, Newcastle University, Newcastle upon Tyne, UK

Tài liệu tham khảo

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