The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery
Tóm tắt
The potential of the folic acid biosynthesis pathway as a target for the development of antibiotics has been acknowledged for many years and validated by the clinical use of several drugs. Recently, the crystal structures of all but one of the enzymes in the pathway from GTP to dihydrofolate have been determined. Given that structure‐based drug design strategies are now widely employed, these recent developments have prompted a re‐evaluation of the potential of each of the enzymes in the pathway as a target for development of specific inhibitors. Here, we review the current knowledge of the structure and mechanism of each enzyme in the bacterial folic acid biosynthesis pathway from GTP to dihydrofolate and draw conclusions regarding the potential of each enzyme as a target for therapeutic intervention. BioEssays 24:637–648, 2002. © 2002 Wiley Periodicals, Inc.
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Tài liệu tham khảo
Woods DD, 1940, The relationship of p‐aminobenzic acid to the mechanism of the action of sulphanilamide, Br J Exp Pathol, 21, 74
Hitchings GH, 1948, Pyrimidine derivatives as antagonists of pteroylglutamic acid, J Biol Chem, 174, 765, 10.1016/S0021-9258(18)57361-0
Brown GM, 1961, The Biosynthesis of Folic Acid. I. Substrate and cofactor requirements for enzymatic synthesis by cell‐free extracts of Escherichia coli, J Biol Chem, 236, 2534
Yim JJ, 1976, Characteristics of guanosine triphosphate cyclohydrolase I purified from Escherichia coli, J Biol Chem, 251, 5087, 10.1016/S0021-9258(17)33222-2
Reynolds JJ, 1964, The Biosynthesis of Folic Acid. IV. Enzymatic synthesis of dihydrofolic acid from guanine and ribose compounds, J Biol Chem, 239, 317
Richey DP, 1969, The biosynthesis of folic acid. IX. Purification and properties of the enzymes required for the formation of dihydropteroic acid, J Biol Chem, 244, 1582
Suzuki Y, 1974, The biosynthesis of folic acid. XII. Purification and properties of dihydroneopterin triphosphate pyrophosphohydrolase, J Biol Chem, 249, 2405
Johnson LF, 1984, Folates and pterins, 581
Kraut J, 1989, Biological Macromolecules and Assemblies, 1
Sammes PG, 1990, Comprehensive Medicinal Chemistry, 255
Anand N, 1996, Burger's Medicinal Chemistry and Drug Discovery, 527
Gleckman R, 1979, Drug therapy reviews: trimethoprim‐sulfamethoxazole, Am J Hosp Pharm, 36, 893
Washington JA, 1984, Emerging patterns of microbial resistance, Orthop Clin North Am, 15, 417, 10.1016/S0030-5898(20)31092-0
Cartwright KAV, 1995, Meningococcal disease
Burg AW, 1968, The biosynthesis of folic acid. VIII. Purification and properties of the enzyme that catalyzes the production of formate from carbon atom 8 of guanosine triphosphate, J Biol Chem, 243, 2349
Shiota T, 1964, The enzymatic synthesis of folate‐like compounds from hydroxymethyldihydropteridine pyrophosphate, J Biol Chem, 239, 2259, 10.1016/S0021-9258(20)82229-7
Wood HCS, 1975, Chemistry and Biology of Pteridines 5th Annual Symposium
Suckling CJ, 1975, Chemistry and Biology of Pteridines, 73
Ferone R, 1975, Chemistry and Biology of Pteridines, 61
Bognar A, 1985, Folylpoly‐gamma‐glutamate synthetase‐dihydrofolate synthetase. Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product, J Biol Chem, 260, 5625, 10.1016/S0021-9258(18)89069-X
Shane B, 1980, Pteroylpoly(gamma‐glutamate) synthesis by Corynebacterium species. Purification and properties of folypoly(gamma‐glutamate) synthetase, J Biol Chem, 255, 5655, 10.1016/S0021-9258(19)70679-6
Bognar AL, 1983, Purification and properties of Lactobacillus casei folylpoly‐gamma‐glutamate synthetase, J Biol Chem, 258, 12574, 10.1016/S0021-9258(17)44215-3