c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges
Tài liệu tham khảo
Kyriakis, 1990, pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-l-lysine, J. Biol. Chem., 265, 17355, 10.1016/S0021-9258(17)44910-6
Kyriakis, 1991, pp54 microtubule-associated protein-2 kinase requires both tyrosine and threonine phosphorylation for activity, J. Biol. Chem., 266, 10043, 10.1016/S0021-9258(18)99183-0
Hibi, 1993, Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain, Genes Dev., 7, 2135, 10.1101/gad.7.11.2135
Dérijard, 1994, JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain, Cell, 76, 1025, 10.1016/0092-8674(94)90380-8
Kyriakis, 1994, The stress-activated protein kinase subfamily of c-Jun kinases, Nature, 369, 156, 10.1038/369156a0
Kallunki, 1994, JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation, Genes Dev., 8, 2996, 10.1101/gad.8.24.2996
Yang, 1997, Absence of excitotoxicity induced apoptosis in the hippocampus of mice lacking the Jnk3 gene, Nature, 389, 865, 10.1038/39899
Kuan, 2003, A critical role of neural-specific JNK3 for ischemic apoptosis, Proc. Natl. Acad. Sci. U. S. A., 100, 15184, 10.1073/pnas.2336254100
Sabapathy, 1999, Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2, Mech. Dev., 89, 115, 10.1016/S0925-4773(99)00213-0
Kuan, 1999, The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development, Neuron, 22, 667, 10.1016/S0896-6273(00)80727-8
Dong, 2002, MAP kinases in the immune response, Ann. Rev. Immunol., 20, 55, 10.1146/annurev.immunol.20.091301.131133
Bogoyevitch, 2006, The isoform-specific functions of the c-Jun N-terminal kinases (JNKs)—differences revealed by gene targeting, BioEssays, 28, 923, 10.1002/bies.20458
Hirosumi, 2002, A central role for JNK in obesity and insulin resistance, Nature, 420, 333, 10.1038/nature01137
Jaeschke, 2005, Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes, Proc. Natl. Acad. Sci. U. S. A., 102, 6931, 10.1073/pnas.0502143102
Han, 2002, Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis, Arthritis Rheum., 46, 818, 10.1002/art.10104
Gupta, 1996, Selective interaction of JNK protein kinase isoforms with transcription factors, EMBO J., 15, 2760, 10.1002/j.1460-2075.1996.tb00636.x
Xie, 1998, Crystal structure of JNK3: a kinase implicated in neuronal apoptosis, Structure, 6, 983, 10.1016/S0969-2126(98)00100-2
Heo, 2004, Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125, EMBO J., 23, 2185, 10.1038/sj.emboj.7600212
Shaw, 2008, The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity, J. Mol. Biol., 383, 885, 10.1016/j.jmb.2008.08.086
Dickens, 1997, A cytoplasmic inhibitor of the JNK signal transduction pathway, Science, 277, 693, 10.1126/science.277.5326.693
Whitmarsh, 1998, A mammalian scaffold complex that selectively mediates MAP kinase activation, Science, 281, 1671, 10.1126/science.281.5383.1671
Yasuda, 1999, The JIP group of mitogen-activated protein kinase scaffold proteins, Mol. Cell. Biol., 19, 7245, 10.1128/MCB.19.10.7245
Bennett, 2001, SP600125, and anthrapyrazolone inhibitor of Jun N-terminal kinase, Proc. Natl. Acad. Sci. U. S. A., 98, 13681, 10.1073/pnas.251194298
Xia, 1995, Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis, Science, 270, 1326, 10.1126/science.270.5240.1326
Park, 1997, Activation of c-Jun N-terminal kinase antagonizes an anti-apoptotic action of Bcl-2, J. Biol. Chem., 272, 16725, 10.1074/jbc.272.27.16725
Tournier, 2000, Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway, Science, 288, 870, 10.1126/science.288.5467.870
Borsello, 2003, A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia, Nat. Med., 9, 1180, 10.1038/nm911
Bogoyevitch, 2008, Inhibitors of c-Jun N-terminal kinases: JuNK no more?, Biochim. Biophys. Acta, 1784, 76, 10.1016/j.bbapap.2007.09.013
Asano, 2008, Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1), Bioorg. Med. Chem., 16, 4715, 10.1016/j.bmc.2008.02.027
Asano, 2008, Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2), Bioorg. Med. Chem., 16, 4699, 10.1016/j.bmc.2008.02.028
Alam, 2007, Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors, Bioorg. Med. Chem. Lett., 17, 3463, 10.1016/j.bmcl.2007.03.078
Shin, 2009, Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors, Bioorg. Med. Chem. Lett., 19, 3344, 10.1016/j.bmcl.2009.03.086
Kamenecka, 2009, Structure–Activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38., J. Biol. Chem., 284, 12853, 10.1074/jbc.M809430200
Angell, 2007, N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3, Bioorg. Med. Chem. Lett., 17, 1296, 10.1016/j.bmcl.2006.12.003
Christopher, 2009, 1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3, Bioorg. Med. Chem. Lett., 19, 2230, 10.1016/j.bmcl.2009.02.098
Jiang, 2007, 3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors, Bioorg. Med. Chem. Lett., 17, 6378, 10.1016/j.bmcl.2007.08.054
Humphries, 2009, Synthesis and SAR of 4-substituted-2-aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors, Bioorg. Med. Chem. Lett., 19, 2099, 10.1016/j.bmcl.2009.03.023
Resnick, 2004, Targeting JNK3 for the treatment of neurodegenerative disorders, Drug Discov. Today, 9, 932, 10.1016/S1359-6446(04)03251-9
Liu, 2007, Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: synthesis and SAR studies, Bioorg. Med. Chem. Lett., 17, 668, 10.1016/j.bmcl.2006.10.093
Cho, 2008, Pharmacological characterization of a small molecule inhibitor of c-Jun kinase, Am. J. Physiol., 295, E1142
Liu, 2007, Hemodynamic effects of potent and selective JNK inhibitors in anesthetized rats: implication for targeting protein kinases in metabolic diseases, Bioorg. Med. Chem. Lett., 17, 495, 10.1016/j.bmcl.2006.10.013
Mendonsa, 2009, Molecular profiling reveals diversity of stress signal transduction cascades in highly penetrant Alzheimer's disease human skin fibroblasts, PLoS ONE, 4, e4655, 10.1371/journal.pone.0004655
Mucha, 2009, JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand, Gut, 58, 688, 10.1136/gut.2008.154625
Goldstein, 2008, High-throughput kinase profiling as a platform for drug discovery, Nat. Rev. Drug Discov., 7, 391, 10.1038/nrd2541
Bogoyevitch, 2005, Therapeutic promise of JNK ATP-noncompetitive inhibitors, Trends Mol. Med., 11, 232, 10.1016/j.molmed.2005.03.005
Repici, 2007, Time-course of c-Jun N-terminal kinase activation after cerebral ischemia and effect of D-JNKI1 on c-Jun and caspase-3 activation, Neuroscience, 150, 40, 10.1016/j.neuroscience.2007.08.021
Wiegler, 2008, The JNK inhibitor XG-102 protects from ischemic damage with delayed intravenous administration also in the presence of recombinant tissue plasminogen activator, Cerebrovasc. Dis., 26, 360, 10.1159/000151639
Esneault, 2008, D-JNKi, a peptide inhibitor of c-Jun N-terminal kinase, promotes functional recovery after transient focal cerebral ischemia in rats, Neuroscience, 152, 308, 10.1016/j.neuroscience.2007.12.036
Ginet, 2009, Limited role of the c-Jun N-terminal kinase pathway in a neonatal rat model of cerebral hypoxia–ischemia, J. Neurochem., 108, 552, 10.1111/j.1471-4159.2008.05797.x
Eshraghi, 2007, Blocking c-Jun-N-terminal kinase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicity, Hear. Res., 226, 168, 10.1016/j.heares.2006.09.008
Wang, 2007, Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals, Mol. Pharmacol., 71, 654, 10.1124/mol.106.028936
Suckfuell, 2007, Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study, Acta Otolaryngol., 127, 938, 10.1080/00016480601110212
Barkdull, 2007, AM-111 reduces hearing loss in a guinea pig model of acute labyrinthitis, Laryngoscope, 117, 2174, 10.1097/MLG.0b013e3181461f92
Beckham, 2007, Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase, J. Virol., 81, 6984, 10.1128/JVI.00467-07
Sury, 2008, JNK is activated but does not mediate hippocampal neuronal apoptosis in experimental neonatal pneumococcal meningitis, Neurobiol. Dis., 32, 142, 10.1016/j.nbd.2008.07.006
Palin, 2008, Tumor necrosis factor-alpha-induced sickness behavior is impaired by central administration of an inhibitor of c-jun N-terminal kinase, Psychopharmacology, 197, 629, 10.1007/s00213-008-1086-y
Repici, 2008, Specific JNK inhibition by D-JNKI1 protects Purkinje cells from cell death in Lurcher mutant mouse, Cerebellum, 7, 534, 10.1007/s12311-008-0070-8
Pain, 2008, A cell-permeable peptide inhibitor TAT-JBD reduces the MPP+-induced caspase-9 activation but does not prevent the dopaminergic degeneration in substantia nigra of rats, Toxicology, 243, 124, 10.1016/j.tox.2007.09.033
Gao, 2009, JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain., J. Neurosci., 29, 4096, 10.1523/JNEUROSCI.3623-08.2009
Colombo, 2009, JNK regulates APP cleavage and degradation in a model of Alzheimer's disease, Neurobiol. Dis., 33, 518, 10.1016/j.nbd.2008.12.014
Gao, 2009, Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model, Exp. Neurol., 219, 146, 10.1016/j.expneurol.2009.05.006
Farías, 2009, Wnt-5a/JNK signaling promotes the clustering of PSD-95 in hippocampal neurons, J. Biol. Chem., 284, 15857, 10.1074/jbc.M808986200
Fornoni, 2007, The L-isoform but not D-isoforms of a JNK inhibitory peptide protects pancreatic b-cells, Biochem. Biophys. Res. Commun., 354, 227, 10.1016/j.bbrc.2006.12.186
Ijaz, 2009, Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes., Kidney Int., 75, 381, 10.1038/ki.2008.559
Kato, 2008, Distinct role of c-Jun N-terminal kinase isoforms in human neutrophil apoptosis regulated by tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor, J. Interferon. Cytokine Res., 28, 235, 10.1089/jir.2007.0075
Melino, 2008, The effect of the JNK inhibitor, JIP peptide, on human T lymphocyte proliferation and cytokine production, J. Immunol., 181, 7300, 10.4049/jimmunol.181.10.7300
Crisostomo, 2008, Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth factors by an NF kappa B- but not JNK-dependent mechanism, Am. J. Physiol. Cell Physiol., 294, C675, 10.1152/ajpcell.00437.2007
Hui, 2008, Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation, J. Clin. Invest., 118, 3943, 10.1172/JCI37156
Lehnert, 2008, A peptide inhibitor of C-jun N-terminal kinase modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation, Shock, 30, 159, 10.1097/SHK.0b013e31815dd623
Relja, 2009, Inhibition of c-Jun N-terminal Kinase after hemorrhage but before resuscitation mitigates hepatic damage and the inflammatory response in female rats, Shock., 32, 509, 10.1097/SHK.0b013e3181a2530d
Wu, 2009, Inhibition of JNK enhances TGF-beta1-activated Smad2 signaling in mouse embryonic lung., Pediatr. Res., 65, 381, 10.1203/PDR.0b013e3181991c67
Medhora, 2008, Role of JNK in network formation of human lung microvascular endothelial cells, Am. J. Physiol., 294, L676
Guma, 2009, Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression, Proc. Natl. Acad. Sci. U. S. A., 106, 8760, 10.1073/pnas.0902659106
Ahmed, 2009, c-Jun N-terminal kinases inhibitor suppresses the TNF-alpha induced MCP-1 expression in human umbilical vein endothelial cells, Endocrine, 35, 184, 10.1007/s12020-008-9136-0
Repici, 2009, Neuroscience, 159, 94, 10.1016/j.neuroscience.2008.11.049
Barr, 2002, Identification of the critical features of a small peptide inhibitor of JNK activity, J. Biol. Chem., 277, 10987, 10.1074/jbc.M107565200
Bonny, 2001, Cell-permeable inhibitors of JNK: novel blockers of b-cell death, Diabetes, 50, 77, 10.2337/diabetes.50.1.77
Barr, 2004, The critical features and the mechanism of inhibition of a kinase interaction motif-based peptide inhibitor of JNK, J. Biol. Chem., 279, 36327, 10.1074/jbc.M402181200
Chène, 2008, Challenges in design of biochemical assays for the identification of small molecules to target multiple conformations of protein kinases, Drug Discov. Today, 13, 522, 10.1016/j.drudis.2008.03.023
Akritopoulou-Zanze, 2009, Kinase-targeted libraries: the design and synthesis of novel, potent, and selective kinase inhibitors, Drug Discov. Today, 14, 291, 10.1016/j.drudis.2008.12.002
Stebbins, 2008, Identification of a new JNK inhibitor targeting the JNK–JIP interaction site., Proc. Natl. Acad. Sci. U. S. A., 105, 16809, 10.1073/pnas.0805677105
De, 2009, Design, synthesis, and structure–activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase, J. Med. Chem., 52, 1943, 10.1021/jm801503n
De, 2009, Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors, Bioorg. Med. Chem., 17, 2712, 10.1016/j.bmc.2009.02.046
Borhani, 2009, Covalent JNK inhibitors?, Proc. Natl. Acad. Sci. U. S. A., 106, E18, 10.1073/pnas.0812246106
Pellecchia, 2009, Covalent JNK inhibitors?, Proc. Natl. Acad. Sci. U. S. A., 106
Chen, 2009, Identification of small-molecule inhibitors of the JIP–JNK interaction, Biochem. J., 420, 283, 10.1042/BJ20081899
Scapin, 2003, The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity, Chem. Biol., 10, 705, 10.1016/S1074-5521(03)00159-5
Swahn, 2005, Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3, Bioorg. Med. Chem. Lett., 15, 5095, 10.1016/j.bmcl.2005.06.083
Swahn, 2006, Design and synthesis of 2′-anilino-4,4′-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3, Bioorg. Med. Chem. Lett., 16, 1397, 10.1016/j.bmcl.2005.11.039
Zhao, 2006, Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors, J. Med. Chem., 49, 4455, 10.1021/jm060465l
Liu, 2006, Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: targeting the gatekeeper residue and beyond, Bioorg. Med. Chem. Lett., 16, 5723, 10.1016/j.bmcl.2006.08.097
Szczepankiewicz, 2006, Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity, J. Med. Chem., 49, 3563, 10.1021/jm060199b
Liu, 2007, Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: synthesis and SAR studies, Bioorg. Med. Chem. Lett., 17, 668, 10.1016/j.bmcl.2006.10.093
Ember, 2008, Mechanistic characterization for c-jun-N-terminal kinase 1alpha1., Arch. Biochem. Biophys., 477, 324, 10.1016/j.abb.2008.06.001
Niu, 2007, Kinetic characterization of human JNK2alpha2 reaction mechanism using substrate competitive inhibitors, Biochemistry, 46, 4775, 10.1021/bi602423e
Ember, 2008, Kinetic mechanism and inhibitor characterization for c-jun-N-terminal kinase 3alpha1, Biochemistry, 47, 3076, 10.1021/bi701852z
Pellecchia, 2008, Perspectives on NMR in drug discovery: a technique comes of age, Nat. Rev. Drug Discov., 7, 738, 10.1038/nrd2606
Vazquez, 2008, Development of paramagnetic probes for molecular recognition studies in protein kinases., J. Med. Chem., 51, 3460, 10.1021/jm800068w
Ho, 2006, Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases, J. Biol. Chem., 281, 13169, 10.1074/jbc.M601010200
Whitmarsh, 2001, Requirement of the JIP1 scaffold protein for stress-induced JNK activation., Genes Dev., 15, 2421, 10.1101/gad.922801
Jaeschke, 2004, An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue, Genes Dev., 18, 1976, 10.1101/gad.1216504
Dajas-Bailador, 2008, The JIP1 scaffold protein regulates axonal development in cortical neurons., Curr. Biol., 18, 221, 10.1016/j.cub.2008.01.025
Thompson, 2001, Islet-brain1/JNK interacting protein-1 is required for early embryogenesis in mice, J. Biol. Chem., 276, 27745, 10.1074/jbc.C100222200
Yang, 2007, Splice variant-specific stabilization of JNKs by IB1/JIP1, Cell Signal., 19, 2201, 10.1016/j.cellsig.2007.07.001
Nihalani, 2007, Src family kinases directly regulate JIP1 module dynamics and activation, Mol. Cell. Biol., 27, 2431, 10.1128/MCB.01479-06
Xie, 2008, The docking properties of SHIP2 influence both JIP1 tyrosine phosphorylation and JNK activity, Cell Signal., 20, 1432, 10.1016/j.cellsig.2008.03.010
Santos, 2006, Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling, J. Virol., 80, 7667, 10.1128/JVI.00967-06
Tapon, 1998, A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kB signalling pathways, EMBO J., 17, 1395, 10.1093/emboj/17.5.1395
Xu, 2003, POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis, EMBO J., 22, 252, 10.1093/emboj/cdg021
Zhang, 2005, Knock-down of POSH expression is neuroprotective through down-regulating activation of the MLK3–MKK4–JNK pathway following cerebral ischaemia in the rat hippocampal CA1 subfield, J. Neurochem., 95, 784, 10.1111/j.1471-4159.2005.03435.x
McDonald, 2000, b-Arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3, Science, 290, 1574, 10.1126/science.290.5496.1574
Guo, 2008, The beta-arrestin-2 scaffold protein promotes c-Jun N-terminal kinase-3 activation by binding to its nonconserved N terminus, J. Biol. Chem., 283, 15903, 10.1074/jbc.M710006200
López-Bergami, 2005, RACK1 mediates activation of JNK by protein kinase C, Mol. Cell, 19, 309, 10.1016/j.molcel.2005.06.025
Ye, 2007, GRASP-1 is a neuronal scaffold protein for the JNK signaling pathway, FEBS Lett., 581, 4403, 10.1016/j.febslet.2007.08.008
Jeon, 2008, Filamin B serves as a molecular scaffold for type I interferon-induced c-Jun NH2-terminal kinase signaling pathway., Mol. Biol. Cell, 19, 5116, 10.1091/mbc.E08-06-0576
Kadoya, 2005, JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity, Mol. Cell. Biol., 25, 8619, 10.1128/MCB.25.19.8619-8630.2005
Lalioti, 2009, Daxx functions as a scaffold of a protein assembly constituted by GLUT4, JNK1 and KIF5B, J. Cell Physiol., 218, 416, 10.1002/jcp.21614
López-Sánchez, 2007, Mitochondrial c-Jun NH2-terminal kinase prevents the accumulation of reactive oxygen species and reduces necrotic damage in neural tumor cells that lack trophic support, Mol. Cancer Res., 5, 47, 10.1158/1541-7786.MCR-06-0233
Hanawa, 2008, Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury, J. Biol. Chem., 283, 13565, 10.1074/jbc.M708916200
Nagata, 1988, The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3, EMBO J., 17, 149, 10.1093/emboj/17.1.149
Good, 2009, The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation., Cell, 136, 1085, 10.1016/j.cell.2009.01.049
Matsuzawa, 2008, Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex, Science, 321, 663, 10.1126/science.1157340
Bogoyevitch, 2006, Uses for JNK—the many and varied Substrates of c-Jun N-terminal Kinases, Microbiol. Mol. Biol. Rev., 70, 1061, 10.1128/MMBR.00025-06
Chen, 1996, The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation, J. Biol. Chem., 271, 31929, 10.1074/jbc.271.50.31929
Park, 2007, Phosphorylation of Smac by JNK3 attenuates its interaction with XIAP, Biochem. Biophys. Res. Commun., 361, 994, 10.1016/j.bbrc.2007.07.121
Leung, 2008, Activation of the JNK pathway promotes phosphorylation and degradation of BimEL—a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia, Carcinogenesis, 29, 544, 10.1093/carcin/bgm294
Mielke, 2008, Growth-arrest-dependent expression and phosphorylation of p27kip at serine10 is mediated by the JNK pathway in C6 glioma cells, Mol. Cell. Neurosci., 38, 301, 10.1016/j.mcn.2007.12.007
Wu, 2008, JNK1 regulates histone acetylation in trigeminal neurons following chemical stimulation, Biochem. Biophys. Res. Commun., 376, 781, 10.1016/j.bbrc.2008.09.073
Gorentla, 2009, Proline-directed phosphorylation of the dopamine transporter N-terminal domain, Biochemistry, 48, 1067, 10.1021/bi801696n
Choi, 2009, c-Jun N-terminal kinase 1 phosphorylates Myt1 to prevent UVA-induced skin cancer, Mol. Cell. Biol., 29, 2168, 10.1128/MCB.01508-08
Awano, 2008, Phosphorylation of protein phosphatase 2Czeta by c-Jun NH2-terminal kinase at Ser92 attenuates its phosphatase activity, Biochemistry, 47, 7248, 10.1021/bi800067p
Morel, 2009, Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis, Mol. Cell. Biol., 29, 3845, 10.1128/MCB.00279-09
Lin, 2009, Chronic high-dose morphine treatment promotes SH-SY5Y cell apoptosis via c-Jun N-terminal kinase-mediated activation of mitochondria-dependent pathway, FEBS J., 276, 2022, 10.1111/j.1742-4658.2009.06938.x
Zhou, 2008, c-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons, J. Neurochem., 104, 325
Eminel, 2004, JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine, J. Biol. Chem., 279, 55385, 10.1074/jbc.M405858200
Ogata, 2006, Autophagy is activated for cell survival after endoplasmic reticulum stress, Mol. Cell. Biol., 26, 9220, 10.1128/MCB.01453-06
Wei, 2008, JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy, Mol. Cell, 30, 678, 10.1016/j.molcel.2008.06.001
Wei, 2008, Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation, Autophagy, 4, 949, 10.4161/auto.6788
Li, 2009, The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells, Oncogene, 28, 886, 10.1038/onc.2008.441
Park, 2009, Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death, Biochem. Biophys. Res. Commun., 382, 726, 10.1016/j.bbrc.2009.03.095
Wu, 2009, JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy, Mech. Dev., 126, 624, 10.1016/j.mod.2009.06.1082
Nishida, 2008, Crosstalk between autophagy and apoptosis in heart disease, Circ. Res., 103, 343, 10.1161/CIRCRESAHA.108.175448
Shaw, 2008, Molecular regulation of autophagy and apoptosis during ischemic and non-ischemic cardiomyopathy., Autophagy, 4, 427, 10.4161/auto.5901
Brodersen, 2009, Revisiting the principles of microRNA target recognition and mode of action, Nat. Rev. Mol. Cell Biol., 10, 141, 10.1038/nrm2619
Chua, 2009, MicroRNAs: biogenesis, function and applications, Curr. Opin. Mol. Ther., 11, 189
O'Connell, 2007, MicroRNA-155 is induced during the macrophage inflammatory response, Proc. Natl. Acad. Sci. U. S. A., 104, 1604, 10.1073/pnas.0610731104
Yin, 2008, B-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element, J. Biol. Chem., 283, 2654, 10.1074/jbc.M708218200
Rozo, 2008, Silencing Jnk1 and Jnk2 accelerates basal lipolysis and promotes fatty acid re-esterification in mouse adipocytes, Diabetologia, 51, 1493, 10.1007/s00125-008-1036-6
Varona-Santos, 2008, c-Jun N-terminal kinase 1 is deleterious to the function and survival of murine pancreatic islets, Diabetologia, 51, 2271, 10.1007/s00125-008-1169-7
Fukuda, 2008, c-Jun amino terminal kinase 1 deficient mice are protected from streptozotocin-induced islet injury, Biochem. Biophys. Res. Commun., 366, 710, 10.1016/j.bbrc.2007.12.007
Singh, 2009, Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance, Hepatology, 49, 87, 10.1002/hep.22578
Kodama, 2009, c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: multiple roles in multiple steps, Hepatology, 49, 6, 10.1002/hep.22710
Tong, 2007, c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression, Am. J. Pathol., 171, 297, 10.2353/ajpath.2007.061036
Yang, 2007, Liver-specific knockdown of JNK1 upregulates PGC-1beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced diabetic mice, J. Biol. Chem., 282, 22765, 10.1074/jbc.M700790200
Solinas, 2007, JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity, Cell Metab., 6, 386, 10.1016/j.cmet.2007.09.011
Das, 2007, Suppression of p53-dependent senescence by the JNK signal transduction pathway, Proc. Natl. Acad. Sci. U. S. A., 104, 15759, 10.1073/pnas.0707782104
Das, 2009, Induction of hepatitis by JNK-mediated expression of TNF-alpha, Cell, 136, 249, 10.1016/j.cell.2008.11.017
Ma, 2009, Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat, Lab. Invest., 89, 470, 10.1038/labinvest.2009.2
Sabio, 2008, A stress signaling pathway in adipose tissue regulates hepatic insulin resistance, Science, 322, 1539, 10.1126/science.1160794
Liu, 2009, Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth, Circ. Res., 104, 905, 10.1161/CIRCRESAHA.108.188292
Petrich, 2003, Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination, FASEB J., 17, 749, 10.1096/fj.02-0438fje
Waetzig, 2008, c-Jun N-terminal kinases mediate Fas-induced neurite regeneration in PC12 cells, Biochem. Pharmacol., 76, 1476, 10.1016/j.bcp.2008.07.014
Waetzig, 2009, Concurrent protective and destructive signaling of JNK2 in neuroblastoma cells., Cell. Signal., 21, 873, 10.1016/j.cellsig.2009.01.032