The ever-increasing complexities of the exon junction complex

Orphanides, 2002, A unified theory of gene expression, Cell, 108, 439, 10.1016/S0092-8674(02)00655-4

Reed, 2003, Coupling transcription, splicing and mRNA export, Curr Opin Cell Biol, 15, 326, 10.1016/S0955-0674(03)00048-6

Rosonina, 2002, Gene expression: the close coupling of transcription and splicing, Curr Biol, 12, R319, 10.1016/S0960-9822(02)00829-1

Cheng, 1994, Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance, Mol Cell Biol, 14, 6317, 10.1128/MCB.14.9.6317

Carter, 1996, A splicing-dependent regulatory mechanism that detects translation signals, EMBO J, 15, 5965, 10.1002/j.1460-2075.1996.tb00983.x

Thermann, 1998, Binary specification of nonsense codons by splicing and cytoplasmic translation, EMBO J, 17, 3484, 10.1093/emboj/17.12.3484

Nagy, 1998, A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance, Trends Biochem Sci, 23, 198, 10.1016/S0968-0004(98)01208-0

Li, 1998, Nonsense surveillance in lymphocytes?, Immunity, 8, 135, 10.1016/S1074-7613(00)80466-5

Wagner, 2002, mRNA surveillance: the perfect persist, J Cell Sci, 115, 3033, 10.1242/jcs.115.15.3033

Braddock, 1994, Intron-less RNA injected into the nucleus of Xenopus oocytes accesses a regulated translation control pathway, Nucleic Acids Res, 22, 5255, 10.1093/nar/22.24.5255

Matsumoto, 1998, Nuclear history of a pre-mRNA determines the translational activity of cytoplasmic mRNA, EMBO J, 17, 2107, 10.1093/emboj/17.7.2107

Luo, 1999, Splicing is required for rapid and efficient mRNA export in metazoans, Proc Natl Acad Sci USA, 96, 14937, 10.1073/pnas.96.26.14937

Le Hir, 2000, Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions, Genes Dev, 14, 1098, 10.1101/gad.14.9.1098

Kataoka, 2000, Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm, Mol Cell, 6, 673, 10.1016/S1097-2765(00)00065-4

Le Hir, 2000, The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions, EMBO J, 19, 6860, 10.1093/emboj/19.24.6860

Le Hir, 2003, How introns influence and enhance eukaryotic gene expression, Trends Biochem Sci, 28, 215, 10.1016/S0968-0004(03)00052-5

Jurica, 2002, Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis, RNA, 8, 426, 10.1017/S1355838202021088

Reichert, 2002, 5′ exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly, Genes Dev, 16, 2778, 10.1101/gad.1030602

Jurica, 2003, Pre-mRNA splicing: awash in a sea of proteins, Mol Cell, 12, 5, 10.1016/S1097-2765(03)00270-3

Le Hir, 2001, The exon–exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay, EMBO J, 20, 4987, 10.1093/emboj/20.17.4987

Le Hir, 2001, The protein Mago provides a link between splicing and mRNA localization, EMBO Rep, 2, 1119, 10.1093/embo-reports/kve245

Kim, 2001, The Y14 protein communicates to the cytoplasm the position of exon–exon junctions, EMBO J, 20, 2062, 10.1093/emboj/20.8.2062

Fribourg, 2003, A novel mode of RBD-protein recognition in the Y14–Mago complex, Nat Struct Biol, 10, 433, 10.1038/nsb926

Shi, 2003, Crystal structure of the Drosophila Mago nashi-Y14 complex, Genes Dev, 17, 971, 10.1101/gad.260403

Lau, 2003, Structure of the y14-magoh core of the exon junction complex, Curr Biol, 13, 933, 10.1016/S0960-9822(03)00328-2

Shibuya T, Tange TO, Sonenberg N, Moore MJ: eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. Nat Struct Mol Biol 2004, in press.

Ferraiuolo MA, Lee C, Ler LW, Hsu JL, Costa-Mattioli M, Luo M, Reed R, Sonenberg N: A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. Proc Natl Acad Sci USA 2004, in press.

Palacios, 2004, An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay, Nature, 427, 753, 10.1038/nature02351

Chan, 2004, eIF4A3 is a novel component of the exon junction complex, RNA, 10, 200, 10.1261/rna.5230104

Kim, 1998, Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding, Structure, 6, 89, 10.1016/S0969-2126(98)00010-0

Tanner, 2001, DExD/H box RNA helicases: from generic motors to specific dissociation functions, Mol Cell, 8, 251, 10.1016/S1097-2765(01)00329-X

Kataoka, 2001, Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon–exon junction complex, EMBO J, 20, 6424, 10.1093/emboj/20.22.6424

Kim, 2001, Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon–exon junction complex, Science, 293, 1832, 10.1126/science.1062829

Li, 2003, Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1, Mol Cell Biol, 23, 7363, 10.1128/MCB.23.20.7363-7376.2003

Luo, 2001, Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly, Nature, 413, 644, 10.1038/35098106

Stutz, 2003, The interplay of nuclear mRNP assembly, mRNA surveillance and export, Trends Cell Biol, 13, 319, 10.1016/S0962-8924(03)00106-5

Ishigaki, 2001, Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20, Cell, 106, 607, 10.1016/S0092-8674(01)00475-5

Lejeune, 2002, The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling, EMBO J, 21, 3536, 10.1093/emboj/cdf345

Zhou, 2000, The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans, Nature, 407, 401, 10.1038/35030160

Gatfield, 2001, The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila, Curr Biol, 11, 1716, 10.1016/S0960-9822(01)00532-2

Jensen, 2001, The DECD box putative ATPase Sub2p is an early mRNA export factor, Curr Biol, 11, 1711, 10.1016/S0960-9822(01)00529-2

Stutz, 2000, REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export, RNA, 6, 638, 10.1017/S1355838200000078

Rodrigues, 2001, REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus, Proc Natl Acad Sci USA, 98, 1030, 10.1073/pnas.031586198

Gatfield, 2002, REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export, J Cell Biol, 159, 579, 10.1083/jcb.200207128

Longman, 2003, The Ref/Aly proteins are dispensable for mRNA export and development in Caenorhabditis elegans, RNA, 9, 881, 10.1261/rna.5420503

MacMorris, 2003, UAP56 levels affect viability and mRNA export in Caenorhabditis elegans, RNA, 9, 847, 10.1261/rna.5480803

Mohr, 2001, The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosophila oogenesis, Genes Dev, 15, 2886, 10.1101/gad.927001

Hachet, 2001, Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport, Curr Biol, 11, 1666, 10.1016/S0960-9822(01)00508-5

Palacios, 2002, RNA processing: splicing and the cytoplasmic localisation of mRNA, Curr Biol, 12, R50, 10.1016/S0960-9822(01)00671-6

Steward, 2003, Compartmentalized synthesis and degradation of proteins in neurons, Neuron, 40, 347, 10.1016/S0896-6273(03)00635-4

Lu, 2003, Analysis of the stimulatory effect of splicing on mRNA production and utilization in mammalian cells, RNA, 9, 618, 10.1261/rna.5260303

Nott, 2003, A quantitative analysis of intron effects on mammalian gene expression, RNA, 9, 607, 10.1261/rna.5250403

Noe, 2003, An intron is required for dihydrofolate reductase protein stability, J Biol Chem, 278, 38292, 10.1074/jbc.M212746200

Wiegand, 2003, Exon junction complexes mediate the enhancing effect of splicing on mRNA expression, Proc Natl Acad Sci USA, 100, 11327, 10.1073/pnas.1934877100

Nott, 2004, Splicing enhances translation in mammalian cells: an additional function of the exon junction complex, Genes Dev, 18, 210, 10.1101/gad.1163204

Schell T, Kulozik AE, Hentze MW: Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway. Genome Biol 2002, 3:REVIEWS1006.

Culbertson, 2003, Looking at mRNA decay pathways through the window of molecular evolution, Curr Opin Genet Dev, 13, 207, 10.1016/S0959-437X(03)00014-5

Lykke-Andersen, 2001, Communication of the position of exon–exon junctions to the mRNA surveillance machinery by the protein RNPS1, Science, 293, 1836, 10.1126/science.1062786

Gehring, 2003, Y14 and hUpf3b form an NMD-activating complex, Mol Cell, 11, 939, 10.1016/S1097-2765(03)00142-4

Lykke-Andersen, 2002, Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay, Mol Cell Biol, 22, 8114, 10.1128/MCB.22.23.8114-8121.2002

Chen, 2003, Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway, Mol Cell Biol, 23, 4805, 10.1128/MCB.23.14.4805-4813.2003

Lejeune, 2003, Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities, Mol Cell, 12, 675, 10.1016/S1097-2765(03)00349-6

Gonzalez, 2001, Nonsense-mediated mRNA decay in Saccharomyces cerevisiae, Gene, 274, 15, 10.1016/S0378-1119(01)00552-2

Gatfield, 2003, Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways, EMBO J, 22, 3960, 10.1093/emboj/cdg371