A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis

Bioactive Materials - Tập 10 - Trang 207-221 - 2022
Yongzhi Cui1,2, Yuanyuan Guo3, Li Kong4, Jingyu Shi3, Ping Liu5, Rui Li2, Yongtao Geng2, Weihang Gao5, Zhiping Zhang4, Dehao Fu1,2
1Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China
2Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, PR China
3Department of Pharmacy, Liyuan Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei, 430077, PR China
4Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
5Department of Orthopaedics, Liyuan Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, 430077, PR China

Tài liệu tham khảo

1993, Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis, Am. J. Med., 94, 646, 10.1016/0002-9343(93)90218-E Compston, 2019, Osteoporosis, Lancet, 393, 364, 10.1016/S0140-6736(18)32112-3 Black, 2016, Clinical practice. Postmenopausal osteoporosis, N. Engl. J. Med., 374, 254, 10.1056/NEJMcp1513724 Brown, 2017, Osteoporosis: staying strong, Nature, 550, s15, 10.1038/550S15a Luhmann, 2012, Bone targeting for the treatment of osteoporosis, J. Contr. Release, 161, 198, 10.1016/j.jconrel.2011.10.001 Kusumbe, 2014, Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone, Nature, 507, 323, 10.1038/nature13145 Yang, 2017, MiR-497 approximately 195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1alpha activity, Nat. Commun., 8, 16003, 10.1038/ncomms16003 Wang, 2017, Human type H vessels are a sensitive biomarker of bone mass, Cell Death Dis., 8, 10.1038/cddis.2017.36 Song, 2020, Nuciferine prevents bone loss by disrupting multinucleated osteoclast formation and promoting type H vessel formation, Faseb. J., 34, 4798, 10.1096/fj.201902551R Yang, 2020, Ophiopogonin D promotes bone regeneration by stimulating CD31hi EMCNhi vessel formation, Cell Prolif, 53, 10.1111/cpr.12784 Shim, 2013, Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts, J. Clin. Invest., 123, 4010, 10.1172/JCI69443 Jones, 2006, Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3, Science, 312, 1223, 10.1126/science.1126313 Wein, 2012, Control of bone resorption in mice by Schnurri-3, Proc. Natl. Acad. Sci. U. S. A., 109, 8173, 10.1073/pnas.1205848109 Xu, 2018, Targeting skeletal endothelium to ameliorate bone loss, Nat. Med., 24, 823, 10.1038/s41591-018-0020-z Yang, 2019, Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis, Nat. Commun., 10, 2958, 10.1038/s41467-019-10809-6 Lu, 2020, Bioinspired exosome-like therapeutics and delivery nanoplatforms, Biomaterials, 242, 119925, 10.1016/j.biomaterials.2020.119925 Liu, 2020, The application of MSCs-derived extracellular vesicles in bone disorders: novel cell-free therapeutic strategy, Front. Cell. Dev. Biol., 8, 619, 10.3389/fcell.2020.00619 Phinney, 2017, Concise review: MSC-derived exosomes for cell-free therapy, Stem Cell., 35, 851, 10.1002/stem.2575 Fan, 2020, Generation of small RNA-modulated exosome mimetics for bone regeneration, ACS Nano, 14, 11973, 10.1021/acsnano.0c05122 Brennan, 2020, Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration, Adv. Funct. Mater., 30, 1909125, 10.1002/adfm.201909125 Zhang, 2015, Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis, J. Transl. Med., 13, 49, 10.1186/s12967-015-0417-0 Hu, 2015, Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells attenuate limb ischemia by promoting angiogenesis in mice, Stem Cell Res. Ther., 6, 10, 10.1186/scrt546 Alvarez-Erviti, 2011, Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes, Nat. Biotechnol., 29, 341, 10.1038/nbt.1807 Wang, 2017, Nucleolin-targeted extracellular vesicles as a versatile platform for biologics delivery to breast cancer, Theranostics, 7, 1360, 10.7150/thno.16532 Jiang, 2020, Dying tumor cell-derived exosomal miR-194-5p potentiates survival and repopulation of tumor repopulating cells upon radiotherapy in pancreatic cancer, Mol. Canc., 19, 68, 10.1186/s12943-020-01178-6 Nakashima, 2011, Evidence for osteocyte regulation of bone homeostasis through RANKL expression, Nat. Med., 17, 1231, 10.1038/nm.2452 Yan, 2019, Vascularized 3D printed scaffolds for promoting bone regeneration, Biomaterials, 190–191, 97, 10.1016/j.biomaterials.2018.10.033 Zhai, 2020, Human mesenchymal stem cell derived exosomes enhance cell‐free bone regeneration by altering their miRNAs profiles, Adv. Sci., 2001334, 10.1002/advs.202001334 Xia, 2020, Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke, Stem Cell Res. Ther., 11, 313, 10.1186/s13287-020-01834-0 Zou, 2019, Aptamer-functionalized exosomes: elucidating the cellular uptake mechanism and the potential for cancer-targeted chemotherapy, Anal. Chem., 91, 2425, 10.1021/acs.analchem.8b05204 Guo, 2015, Erythrocyte membrane-enveloped polymeric nanoparticles as nanovaccine for induction of antitumor immunity against melanoma, ACS Nano, 9, 6918, 10.1021/acsnano.5b01042 He, 2018, Lipid-based liquid crystalline nanoparticles facilitate cytosolic delivery of siRNA via structural transformation, Nano Lett., 18, 2411, 10.1021/acs.nanolett.7b05430 Yao, 2019, Stem cell derived exosomes: microRNA therapy for age-related musculoskeletal disorders, Biomaterials, 224, 119492, 10.1016/j.biomaterials.2019.119492 Qi, 2016, Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells repair critical-sized bone defects through enhanced angiogenesis and osteogenesis in osteoporotic rats, Int. J. Biol. Sci., 12, 836, 10.7150/ijbs.14809 Tao, 2018, Modularized extracellular vesicles: the dawn of prospective personalized and precision medicine, Adv. Sci., 5, 1700449, 10.1002/advs.201700449 Li, 2017, Improved calvarial bone repair by hASCs engineered with Cre/loxP-based baculovirus conferring prolonged BMP-2 and MiR-148b co-expression, J. Tissue Eng. Regen. Med., 11, 3068, 10.1002/term.2208 Zhang, 2011, MiRNA-20a promotes osteogenic differentiation of human mesenchymal stem cells by co-regulating BMP signaling, RNA Biol., 8, 829, 10.4161/rna.8.5.16043 Sun, 2015, mir-21 overexpressing mesenchymal stem cells accelerate fracture healing in a rat closed femur fracture model, BioMed Res. Int., 2015, 412327, 10.1155/2015/412327 Yang, 2013, Tumor necrosis factor α suppresses the mesenchymal stem cell osteogenesis promoter miR-21 in estrogen deficiency-induced osteoporosis, J. Bone Miner. Res., 28, 559, 10.1002/jbmr.1798 Huang, 2012, Upregulation of miR-22 promotes osteogenic differentiation and inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells by repressing HDAC6 protein expression, Stem Cell. Dev., 21, 2531, 10.1089/scd.2012.0014 Sun, 2019, MiR-26a promotes fracture healing of nonunion rats possibly by targeting SOSTDC1 and further activating Wnt/β-catenin signaling pathway, Mol. Cell. Biochem., 460, 165, 10.1007/s11010-019-03578-9 Zhou, 2019, MicroRNA-100-5p inhibits osteoclastogenesis and bone resorption by regulating fibroblast growth factor 21, Int. J. Mol. Med., 43, 727 Guo, 2014, MiR-125a TNF receptor-associated factor 6 to inhibit osteoclastogenesis, Exp. Cell Res., 321, 142, 10.1016/j.yexcr.2013.12.001 Kim, 2015, MicroRNA-26a regulates RANKL-induced osteoclast formation, Mol. Cell., 38, 75 Nakasa, 2011, The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis, Arthritis Rheum., 63, 1582, 10.1002/art.30321 Bellera, 2014, Single intracoronary injection of encapsulated antagomir-92a promotes angiogenesis and prevents adverse infarct remodeling, J. Am. Heart Assoc., 3, 10.1161/JAHA.114.000946 Xu, 2019, Exosomal miR-423-5p mediates the proangiogenic activity of human adipose-derived stem cells by targeting Sufu, Stem Cell Res. Ther., 10, 106, 10.1186/s13287-019-1196-y Qiao, 2019, microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential, J. Clin. Invest., 129, 2237, 10.1172/JCI123135 Beltrami, 2017, Human pericardial fluid contains exosomes enriched with cardiovascular-expressed MicroRNAs and promotes therapeutic angiogenesis, Mol. Ther., 25, 679, 10.1016/j.ymthe.2016.12.022 Kuehbacher, 2007, Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis, Circ. Res., 101, 59, 10.1161/CIRCRESAHA.107.153916 Sun, 2016, Osteoblast-targeting-peptide modified nanoparticle for siRNA/microRNA delivery, ACS Nano, 10, 5759, 10.1021/acsnano.5b07828 Roeder, 2016, Visual reporters for study of the osteoblast lineage, Bone, 92, 189, 10.1016/j.bone.2016.09.004 Dallas, 2013, The osteocyte: an endocrine cell and more, Endocr. Rev., 34, 658, 10.1210/er.2012-1026 Ching, 2017, Expression of odontogenic and osteogenic markers in DPSCs and SHED: a review, Curr. Stem Cell Res. Ther., 12, 71, 10.2174/1574888X11666160815095733 Li, 2020, Osteoclasts are not a source of SLIT3, Bone Res., 8, 11, 10.1038/s41413-020-0086-3 Wang, 2020, Bone-targeted extracellular vesicles from mesenchymal stem cells for osteoporosis therapy, Int. J. Nanomed., 15, 7967, 10.2147/IJN.S263756 Luo, 2019, Aptamer-functionalized exosomes from bone marrow stromal cells target bone to promote bone regeneration, Nanoscale, 11, 20884, 10.1039/C9NR02791B Hu, 2021, Exosome-guided bone tar-geted delivery of Antagomir-188 as an anabolic therapy for bone loss, Bioact. Mater., 6, 2905, 10.1016/j.bioactmat.2021.02.014 Kimbrel, 2020, Next-generation stem cells-ushering in a new era of cell-based therapies, Nat. Rev. Drug Discov., 19, 463, 10.1038/s41573-020-0064-x Sabapathy, 2016, hiPSC-derived iMSCs: NextGen MSCs as an advanced therapeutically active cell resource for regenerative medicine, J. Cell Mol. Med., 20, 1571, 10.1111/jcmm.12839