Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Nature Genetics - Tập 50 Số 5 - Trang 668-681 - 2018
Naomi R. Wray1, Stephan Ripke2, Manuel Mattheisen3, Maciej Trzaskowski1, Enda M. Byrne1, Abdel Abdellaoui4, Mark J. Adams5, Esben Agerbo6, Tracy Air7, Till F. M. Andlauer8, Silviu‐Alin Bacanu9, Marie Bækvad‐Hansen6, Aartjan T.F. Beekman10, Tim B. Bigdeli9, Elisabeth B. Binder8, Douglas Blackwood5, Julien Bryois11, Henriette N. Buttenschøn12, Jonas Bybjerg‐Grauholm6, Na Cai13, Enrique Castelao14, Jane Christensen3, Toni‐Kim Clarke5, Jonathan R. I. Coleman15, Lucía Colodro‐Conde16, Baptiste Couvy‐Duchesne17, Nick Craddock18, Gregory E. Crawford19, Cheynna Crowley20, Hassan S. Dashti2, Gail Davies21, Ian J. Deary21, Franziska Degenhardt22, Eske M. Derks16, Neşe Direk23, Conor V. Dolan4, Erin C. Dunn24, Thalia C. Eley15, Nicholas Eriksson25, Valentina Escott‐Price26, Farnush Hassan Farhadi Kiadeh27, Hilary K. Finucane28, Andreas J. Forstner22, Josef Frank29, Héléna A. Gaspar15, Michael O’Donovan30, Paola Giusti‐Rodríguez31, Fernando S. Goes32, Scott D. Gordon33, Jakob Grove6, Lynsey S. Hall5, Eilís Hannon34, Christine Søholm Hansen6, Thomas Hansen35, Stefan Herms22, Ian B. Hickie36, Per Hoffmann22, Georg Homuth37, Carsten Horn38, Jouke‐Jan Hottenga4, David M. Hougaard6, Ming Hu39, Craig Hyde40, Stefan Kloiber41, Anna Jansen10, Fulai Jin42, Eric Jorgenson43, Joshua W. Knowles44, Isaac S. Kohane45, Julia Kraft46, Warren W. Kretzschmar47, Jesper Krogh48, Zoltán Kutalik49, Jacqueline M. Lane2, Yihan Li47, Yun Li20, Penelope A. Lind16, Xiaoxiao Liu50, Leina Lu50, Donald J. MacIntyre51, Dean F. MacKinnon32, Robert Maier17, Wolfgang Maier52, Jonathan Marchini53, Hamdi Mbarek4, Patrick J. McGrath54, Peter McGuffin15, Sarah E. Medland16, Divya Mehta17, Christel M. Middeldorp4, Reedik Mägi55, Yuri Milaneschi10, Lili Milani55, Jonathan Mill34, Francis J. McMahon32, Grant W. Montgomery1, Sara Mostafavi56, Niamh Mullins15, Matthias Nauck57, Bernard Ng58, Michel G. Nivard4, Dale R. Nyholt59, Paul F. O’Reilly15, Högni Óskarsson60, Michael J. Owen61, Jodie N. Painter16, Carsten Bøcker Pedersen62, Roseann E. Peterson9, Erik Pettersson11, David Schlessinger10, Giorgio Pistis14, Daniëlle Posthuma63, Shaun Purcell64, Jorge A. Quiroz65, Per Qvist6, John P. Rice66, Brien P. Riley9, Margarita Rivera15, Saira Saeed Mirza67, Richa Saxena68, Robert A. Schoevers69, Eva C. Schulte70, Ling Shen43, Jianxin Shi71, Stanley I. Shyn72, Engilbert Sigurðsson73, Grant B. C. Sinnamon74, Johannes H. Smit10, Daniel J. Smıth75, Hreinn Stefánsson76, Stacy Steinberg76, Craig A. Stockmeier77, Fabian Streit29, Jana Strohmaier29, Katherine E. Tansey78, Henning Teismann79, Alexander Teumer80, Wesley K. Thompson81, Pippa A. Thomson82, Thorgeir E. Thorgeirsson76, Qingqin S. Li25, Matthew Traylor83, Jens Treutlein29, Vassily Trubetskoy46, André G. Uitterlinden84, Daniel Umbricht85, Sandra Van der Auwera86, Albert M. van Hemert87, Alexander Viktorin11, Peter M. Visscher17, Yunpeng Wang81, Bradley T. Webb88, Shantel Weinsheimer81, Jürgen Wellmann79, Gonneke Willemsen4, Stephanie H. Witt29, Yang Wu1, Hualin Simon Xi89, Jian Yang17, Futao Zhang1, Volker Arolt90, Bernhard T. Baune7, Kenneth I. Berger79, Dorret I. Boomsma4, Sven Cichon91, Udo Dannlowski90, E. C. J. de Geus4, J. Raymond DePaulo32, Enrico Domenici92, Katharina Domschke93, Tõnu Esko55, Hans J. Grabe86, Steven P. Hamilton94, Caroline Hayward95, Andrew C. Heath66, David A. Hinds25, Kenneth S. Kendler9, Glyn Lewis96, Susanne Lucae41, Pamela Madden66, Patrik K. E. Magnusson11, Nicholas G. Martin33, Andrew M. McIntosh21, Andres Metspalu55, Ole Mors97, Preben Bo Mortensen62, Bertram Müller‐Myhsok98, Merete Nordentoft99, Markus M. Nöthen100, Sara A. Paciga101, Nancy L. Pedersen11, Brenda W.J.H. Penninx10, Roy H. Perlis102, David J. Porteous82, James B. Potash103, Martin Preisig14, Marcella Rietschel29, Thomas G. Schulze32, Jordan W. Smoller104, Kári Stefánsson76, Henning Tiemeier67, Rudolf Uher105, Henry Völzke80, Myrna M. Weissman54, Thomas Werge81, Ashley R. Winslow106, Cathryn M. Lewis15, Douglas F. Levinson107, Gerome Breen15, Anders D. Børglum6, Patrick F. Sullivan31
1Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
2Medical and Population Genetics, Broad Institute, Cambridge, MA USA
3Department of Biomedicine, Aarhus University, Aarhus, Denmark
4Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
5Division of Psychiatry, University of Edinburgh, Edinburgh, UK
6iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark
7Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia
8Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
9Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
10Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands
11Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
12iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark
13Statistical Genomics and Systems Genetics, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK
14Department of Psychiatry, University Hospital of Lausanne, Prilly, Switzerland
15MRC Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK
16Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
17Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia
18Psychological Medicine, Cardiff University, Cardiff, UK
19Center for Genomic and Computational Biology, Duke University, Durham, NC, USA
20Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
21Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
22Institute of Human Genetics, University of Bonn, Bonn, Germany
23Psychiatry, Dokuz Eylul University School of Medicine, Izmir, Turkey
24Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA
25Research, 23andMe, Inc., Mountain View, CA, USA
26Neuroscience and Mental Health, Cardiff University, Cardiff, UK
27Bioinformatics, University of British Columbia, Vancouver, British Columbia, Canada
28Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA
29Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany
30Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
31Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
32Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
33Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
34University of Exeter Medical School, Exeter, UK
35Danish Headache Centre, Department of Neurology, Rigshospitalet, Glostrup, Denmark
36Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia
37Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine and Ernst Moritz Arndt University Greifswald, Greifswald, Germany
38Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann–La Roche, Ltd, Basel, Switzerland
39Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA
40Statistics, Pfizer Global Research and Development, Groton, CT, USA
41Max Planck Institute of Psychiatry, Munich, Germany
42Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA
43Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA;
44Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA
45Informatics Program, Boston Children's Hospital, Boston, MA, USA
46Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, Germany
47Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
48Department of Endocrinology at Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark
49Swiss Institute of Bioinformatics, Lausanne, Switzerland
50Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA
51Mental Health, NHS 24, Glasgow, UK
52Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
53Statistics, University of Oxford, Oxford, UK
54Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
55Estonian Genome Center, University of Tartu, Tartu, Estonia
56Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
57DZHK (German Centre for Cardiovascular Research), partner site Greifswald, University Medicine, University Medicine Greifswald, Greifswald, Germany
58Statistics, University of British Columbia, Vancouver, British Columbia, Canada
59Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
60Humus, Reykjavik, Iceland
61MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK
62National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark
63Complex Trait Genetics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
64Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA
65Solid Biosciences, Boston, MA, USA
66Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA
67Epidemiology, Erasmus MC, Rotterdam, The Netherlands
68Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA;
69Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
70Department of Psychiatry and Psychotherapy, Medical Center of the University of Munich, Campus Innenstadt, Munich, Germany
71Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
72Behavioral Health Services, Kaiser Permanente Washington, Seattle, WA, USA
73Faculty of Medicine, Department of Psychiatry, University of Iceland, Reykjavik, Iceland
74School of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia
75Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
76deCODE genetics/Amgen, Inc., Reykjavik, Iceland
77Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
78College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK
79Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany
80Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
81Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, Denmark
82Medical Genetics Section, CGEM, IGMM, University of Edinburgh, Edinburgh, UK
83Clinical Neurosciences, University of Cambridge, Cambridge, UK
84Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
85Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases Discovery and Translational Medicine Area, Roche Innovation Center Basel, F. Hoffmann–La Roche, Ltd, Basel, Switzerland
86Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
87Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands
88Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
89Computational Sciences Center of Emphasis, Pfizer Global Research and Development, Cambridge, MA, USA
90Department of Psychiatry, University of Münster, Munster, Germany
91Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland
92Centre for Integrative Biology, Università degli Studi di Trento, Trento, Italy
93Department of Psychiatry and Psychotherapy, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
94Psychiatry, Kaiser Permanente Northern California, San Francisco, CA, USA
95MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
96Division of Psychiatry, University College London, London, UK
97Psychosis Research Unit, Aarhus University Hospital, Risskov, Aarhus, Denmark
98Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
99Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
100Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany
101Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, USA
102Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
103Psychiatry, University of Iowa, Iowa City, IA, USA
104Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA
105Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
106Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Cambridge, MA, USA
107Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA

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Nature Genetics

Tập 50 Số 5

668-681

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