Prostanoids and prostanoid receptors in signal transduction

Carina L. Bos1,2, Dick J. Richel2, Tita Ritsema1, Maikel P. Peppelenbosch1, Henri H. Versteeg1
1Laboratory for Experimental Internal Medicine, G2-130, Academic Medical Center, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands
2Department of Medical Oncology, F4-224, Academic Medical Center, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands

Tài liệu tham khảo

Adachi, 1996, Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes: Involvement of protein tyrosine kinase and protein kinase C, Hepatology, 23, 1244, 10.1002/hep.510230545 Adams, 1998, Tyrosine kinase and c-Jun NH2-terminal kinase mediate hypertrophic responses to prostaglandin F2alpha in cultured neonatal rat ventricular myocytes, Circulation Research, 83, 167, 10.1161/01.RES.83.2.167 Adie, 1992, Concurrent down-regulation of IP prostanoid receptors and the alpha-subunit of the stimulatory guanine-nucleotide-binding protein (Gs) during prolonged exposure of neuroblastoma x glioma cells to prostanoid agonists. Quantification and functional implications, The Biochemical Journal, 285, 529, 10.1042/bj2850529 Amano, 2003, Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth, Journal of Experimental Medicine, 197, 221, 10.1084/jem.20021408 Aoki, 1999, Signal transduction pathway regulating prostaglandin EP3 receptor-induced neurite retraction: Requirement for two different tyrosine kinases, The Biochemical Journal, 340, 365, 10.1042/0264-6021:3400365 Bastepe, 1999, Identification of a region of the C-terminal domain involved in short-term desensitization of the prostaglandin EP4 receptor, British Journal of Pharmacology, 126, 365, 10.1038/sj.bjp.0702291 Boie, 1995, Molecular cloning and characterization of the human prostanoid DP receptor, The Journal of Biological Chemistry, 270, 18910, 10.1074/jbc.270.32.18910 Branger, 2003, Inhibition of coagulation, fibrinolysis and endothelial cell activation by p38 mitogen-activated protein kinase inhibitor during human endotoxemia, Blood, 101, 4446, 10.1182/blood-2002-11-3338 Breyer, 2001, Prostanoid receptors: Subtypes and signaling, Annual Review of Pharmacology and Toxicology, 41, 661, 10.1146/annurev.pharmtox.41.1.661 Burkey, 1995, Activation of mitogen-activated protein kinase by the human prostaglandin EP3A receptor, Biochemical and Biophysical Research Communications, 211, 152, 10.1006/bbrc.1995.1790 Bushfield, 1985, Inhibition of platelet-activating-factor-induced human platelet activation by prostaglandin D2. Differential sensitivity of platelet transduction processes and functional responses to inhibition by cyclic AMP, The Biochemical Journal, 232, 267, 10.1042/bj2320267 Butler, 2000, Nonapoptotic cell death associated with S-phase arrest of prostate cancer cells via the peroxisome proliferator-activated receptor gamma ligand, 15-deoxy-delta12,14-prostaglandin J2, Cell Growth & Differentiation, 11, 49 Chen, 1998, Prostaglandin F2alpha stimulates the Raf/MEK1/mitogen-activated protein kinase signaling cascade in bovine luteal cells, Endocrinology, 139, 3876, 10.1210/en.139.9.3876 Chiyotani, 1992, Thromboxane A2 mimetic U46619 stimulates ciliary motility of rabbit tracheal epithelial cells, Prostaglandins, 43, 111, 10.1016/0090-6980(92)90080-D Coleman, R. A., Kennedy, I., Humphrey, P. P. A., Bunce, K., & Lumley, P. (1990). Prostanoids and their receptor. In J. C. Emmett (Ed.), Comprehensive medicinal chemistry. Membranes and receptors (Vol. 3, pp. 643–714). Oxford, UK: Pergamon Press. Coleman, 1994, International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes, Pharmacological Reviews, 46, 205 Craven, 1996, Thromboxane/prostaglandin endoperoxide-induced hypertrophy of rat vascular smooth muscle cells is signaled by protein kinase C-dependent increases in transforming growth factor-beta, Hypertension, 28, 169, 10.1161/01.HYP.28.2.169 Dorn, 1993, Thromboxane A2 stimulated signal transduction in vascular smooth muscle, The Journal of Pharmacology and Experimental Therapeutics, 265, 447 Eling, 1994, Cellular proliferation and lipid metabolism: Importance of lipoxygenases in modulating epidermal growth factor-dependent mitogenesis, Cancer and Metastasis Reviews, 13, 397, 10.1007/BF00666106 Ezumi, 1999, Thrombopoietin potentiates agonist-stimulated activation of p38 mitogen-activated protein kinase in human platelets, Biochemical and Biophysical Research Communications, 261, 58, 10.1006/bbrc.1999.0979 Fiorucci, 1996, Epidermal growth factor modulates pepsinogen secretion in guinea pig gastric chief cells, Gastroenterology, 111, 945, 10.1016/S0016-5085(96)70062-8 Forman, 1995, 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma, Cell, 83, 803, 10.1016/0092-8674(95)90193-0 Fujino, 2002, Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2, The Journal of Biological Chemistry, 277, 2614, 10.1074/jbc.M109440200 Funk, 1991, Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment, The FASEB Journal, 5, 2304, 10.1096/fasebj.5.9.1907252 Funk, 1993, Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype, The Journal of Biological Chemistry, 268, 26767, 10.1016/S0021-9258(19)74379-8 Gervais, 2001, Selective modulation of chemokinesis, degranulation, and apoptosisi in eosinophils through PGD2 receptors CRTH2 and DP, The Journal of Allergy and Clinical Immunology, 108, 982, 10.1067/mai.2001.119919 Graves, 1996, Platelet-derived growth factor stimulates protein kinase A through a mitogen-activated protein kinase-dependent pathway in human arterial smooth muscle cells, The Journal of Biological Chemistry, 271, 505, 10.1074/jbc.271.1.505 Hakeda, 1997, Prostaglandin F2alpha stimulates tyrosine phosphorylation and mitogen-activated protein kinase in osteoblastic MC3T3-E1 cells via protein kinase C activation, Endocrinology, 138, 1821, 10.1210/en.138.5.1821 Hatae, 2001, Prostacyclin-dependent apoptosis mediated by PPAR delta, The Journal of Biological Chemistry, 276, 46260, 10.1074/jbc.M107180200 Hebert, 1990, PGE2 inhibits AVP-induced water flow in cortical collecting ducts by protein kinase C activation, American Journal of Physiology, 259, F318 Hinson, 1996, Elevated interleukin 6 is induced by prostaglandin E2 in a murine model of inflammation: Possible role of cyclooxygenase-2, Proceedings of the National Academy of Sciences of the United States of America, 93, 4885, 10.1073/pnas.93.10.4885 Hirai, 2001, Prostaglandin D2 selectively induces chemotaxis in T Helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2, The Journal of Experimental Medicine, 193, 255, 10.1084/jem.193.2.255 Hirata, 1991, Cloning and expression of cDNA for a human thromboxane A2 receptor, Nature, 349, 617, 10.1038/349617a0 Honda, 1993, Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype, The Journal of Biological Chemistry, 268, 7759, 10.1016/S0021-9258(18)53022-2 Hsi, 1998, Inhibition of EGF-dependent mitogenesis by prostaglandin E2 in Syrian hamster embryo fibroblasts, Prostaglandins, Leukotrienes, and Essential Fatty Acids, 58, 271, 10.1016/S0952-3278(98)90036-9 Ichikawa, 1996, Molecular aspects of the structures and functions of the prostaglandin E receptors, Journal of Lipid Mediated Cell Signalling, 14, 83, 10.1016/0929-7855(96)00512-3 Ito, 1994, Prostaglandin F2 alpha receptor is coupled to Gq in cDNA-transfected Chinese hamster ovary cells, Biochemical and Biophysical Research Communications, 200, 756, 10.1006/bbrc.1994.1515 Jiang, 1998, PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines, Nature, 391, 82, 10.1038/34184 Jones, 1995, Activation of thromboxane and prostacyclin receptors elicits opposing effects on vascular smooth muscle cell growth and mitogen-activated protein kinase signaling cascades, Molecular Pharmacology, 48, 890 Katoh, 1998, p160 RhoA-binding kinase ROKalpha induces neurite retraction, The Journal of Biological Chemistry, 273, 2489, 10.1074/jbc.273.5.2489 Kawada, 1992, Eicosanoid-mediated contractility of hepatic stellate cells, The Biochemical Journal, 285, 367, 10.1042/bj2850367 Keelan, 1999, 15-Deoxy-delta(12,14)-prostaglandin J(2), a ligand for peroxisome proliferator-activated receptor-gamma, induces apoptosis in JEG3 choriocarcinoma cells, Biochemical and Biophysical Research Communications, 262, 579, 10.1006/bbrc.1999.1257 Kliewer, 1995, A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation, Cell, 83, 813, 10.1016/0092-8674(95)90194-9 Knezevic, 1993, Identification of Gq as one of the G-proteins which copurify with human platelet thromboxane A2/prostaglandin H2 receptors, The Journal of Biological Chemistry, 268, 26011, 10.1016/S0021-9258(19)74486-X Kobayashi, 2000, Involvement of phosphatidylcholine-specific phospholipase C in thromboxane A2-induced activation of mitogen-activated protein kinase in astrocytoma cells, Journal of Neurochemistry, 74, 2167, 10.1046/j.1471-4159.2000.0742167.x Kunapuli, 1998, Prostaglandin F2alpha (PGF2alpha) and the isoprostane, 8,12-iso-isoprostane F2alpha-III, induce cardiomyocyte hypertrophy. Differential activation of downstream signaling pathways, The Journal of Biological Chemistry, 273, 22442, 10.1074/jbc.273.35.22442 Lee, 1992, Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide, The Journal of Biological Chemistry, 267, 25934, 10.1016/S0021-9258(18)35698-9 Lo, 1998, Prostaglandin I2 analogue, iloprost, down regulates mitogen-activated protein kinases of macrophages, The Journal Surgical Research, 76, 159, 10.1006/jsre.1998.5312 Maier, 1990, Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells, The Journal of Biological Chemistry, 265, 10805, 10.1016/S0021-9258(19)38515-1 Matsumura, 1994, Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of rostral basal forebrain, Proceedings of the National Academy of Sciences of the United States of America, 91, 11998, 10.1073/pnas.91.25.11998 Matsuoka, 2000, Prostaglandin D2 as a mediator of allergic asthma, Science, 287, 2013, 10.1126/science.287.5460.2013 Mayeux, 1989, Human erythroleukemia cells express functional thromboxane A2 prostaglandin H2 receptors, The Journal of Pharmacology and Experimental Therapeutics, 250, 923 McNicol, 1998, Effects of the mitogen-activated protein (MAP) kinase kinase inhibitor 2-(2′-amino-3′-methoxyphenyl)-oxanaphthalen-4-one (PD98059) on human platelet activation, Biochemical Pharmacology, 55, 1759, 10.1016/S0006-2952(97)00632-1 Melien, 1998, Activation of p42/p44 mitogen-activated protein kinase by angiotensin II, vasopressin, norepinephrine, and prostaglandin F2alpha in hepatocytes is sustained, and like the effect of epidermal growth factor, mediated through pertussis toxin-sensitive mechanisms, Journal of Cellular Physiology, 175, 348, 10.1002/(SICI)1097-4652(199806)175:3<348::AID-JCP13>3.0.CO;2-1 Merlie, 1988, Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase), The Journal of Biological Chemistry, 263, 3550, 10.1016/S0021-9258(18)68959-8 Miller, 1996, The mechanism of inhibition of 3T3-L1 preadipocyte differentiation by prostaglandin F2alpha, Endocrinology, 137, 5641, 10.1210/en.137.12.5641 Monneret, 2001, Prostaglandin D2 is a potent chemoatractant for human eosinophils that acts via a oval DP receptor, Blood, 98, 1942, 10.1182/blood.V98.6.1942 Morham, S. G., Langenbach, R., Loftin, C. D., Tiano, H. F., Vouloumanos, N., Jennette, J.C., Mahler, J. F., Kluckman, K. D., Ledford, A., Lee, C. A., & Smithies, (1995). Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse Cell 83(3), 473–482. Morinelli, 1997, Tyrosine phosphorylation of phosphatidylinositol 3-kinase and of the thromboxane A2 (TXA2) receptor by the TXA2 mimetic I-BOP in A7r5 cells, Biochemical Pharmacology, 53, 1823, 10.1016/S0006-2952(97)00005-1 Morinelli, 1994, Thromboxane A2/prostaglandin H2-stimulated mitogenesis of coronary artery smooth muscle cells involves activation of mitogen-activated protein kinase and S6 kinase, The Journal of Biological Chemistry, 269, 5693, 10.1016/S0021-9258(17)37516-6 Morita, 1995, Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2, The Journal of Biological Chemistry, 270, 10902, 10.1074/jbc.270.18.10902 Muthalif, 1998, Signal transduction mechanisms involved in angiotensin-(1–7)-stimulated arachidonic acid release and prostanoid synthesis in rabbit aortic smooth muscle cells, The Journal of Pharmacology and Experimental Therapeutics, 284, 388 Nakao, 1989, Regulation of cAMP metabolism by PGE2 in cortical and medullary thick ascending limb of Henle’s loop, American Journal of Physiology, 256, C652, 10.1152/ajpcell.1989.256.3.C652 Namba, 1993, Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity, Nature, 365, 166, 10.1038/365166a0 Narumiya, 1999, Prostanoid receptors: Structures, properties, and functions, Physiological Reviews, 79, 1193, 10.1152/physrev.1999.79.4.1193 Negishi, 1993, Opposite coupling of prostaglandin E receptor EP3C with Gs and G(o). Stimulation of Gs and inhibition of G(o), The Journal of Biological Chemistry, 268, 26067, 10.1016/S0021-9258(19)74279-3 Nishigaki, 1995, Identification of prostaglandin E receptor ‘EP2’ cloned from mastocytoma cells EP4 subtype, FEBS Letters, 364, 339, 10.1016/0014-5793(95)00421-5 Nishigaki, 1996, Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist, Molecular Pharmacology, 50, 1031 Nishigaki, 1993, Characterization of the prostaglandin E receptor expressed on a cultured mast cell line, BNu-2cl3, Biochemical Pharmacology, 46, 863, 10.1016/0006-2952(93)90495-I Oates, 1982, The 1982 Nobel Prize in Physiology or Medicine, Science, 218, 765, 10.1126/science.6753151 Offermanns, 1994, G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets, Proceedings of the National Academy of Sciences of the United States of America, 91, 504, 10.1073/pnas.91.2.504 Ohmichi, 1997, Role of mitogen-activated protein kinase pathway in prostaglandin F2alpha-induced rat puerperal uterine contraction, Endocrinology, 138, 3103, 10.1210/en.138.8.3103 Oka, 1993, Two types of prostacyclin receptor coupling to stimulation of adenylate cyclase and phosphatidylinositol hydrolysis in a cultured mast cell line BNu-2cl3 cells, Cellular Signalling, 5, 643, 10.1016/0898-6568(93)90059-U O’Neill, 1994, Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: Inhibition by nonsteroidal anti- inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid, Molecular Pharmacology, 45, 245 Oshima, 1996, Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2), Cell, 87, 803, 10.1016/S0092-8674(00)81988-1 Parent, 1999, Internalization of the TXA2 receptor alpha and beta isoforms. Role of the differentially spliced cooh terminus in agonist-promoted receptor internalization, The Journal of Biological Chemistry, 274, 8941, 10.1074/jbc.274.13.8941 Peppelenbosch, 1993, Epidermal growth factor-induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products, Cell, 74, 565, 10.1016/0092-8674(93)80057-L Rao, 1999, A potential role for extracellular signal-regulated kinases in prostaglandin F2alpha-induced protein synthesis in smooth muscle cells, The Journal of Biological Chemistry, 274, 12925, 10.1074/jbc.274.18.12925 Raychowdhury, 1994, Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor, The Journal of Biological Chemistry, 269, 19256, 10.1016/S0021-9258(17)32161-0 Regan, 1994, Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype, Molecular Pharmacology, 46, 213 Reginato, 1998, Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor gamma, The Journal of Biological Chemistry, 273, 1855, 10.1074/jbc.273.4.1855 Reimer, 1992, Effects of EP-receptor subtype specific agonists and other prostanoids on adenylate cyclase activity of duodenal epithelial cells, Prostaglandins, 44, 485, 10.1016/0090-6980(92)90142-G Renz, 1988, Release of tumor necrosis factor-alpha from macrophages. Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides, Journal of Immunology, 141, 2388, 10.4049/jimmunol.141.7.2388 Ricote, 1998, The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation, Nature, 391, 79, 10.1038/34178 Ridley, 1992, The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors, Cell, 70, 389, 10.1016/0092-8674(92)90163-7 Rossi, 2000, Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase, Nature, 403, 103, 10.1038/47520 Sachinidis, 1995, Thromboxane A2 and vascular smooth muscle cell proliferation, Hypertension, 26, 771, 10.1161/01.HYP.26.5.771 Saklatvala, 1996, Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue, The Journal of Biological Chemistry, 271, 6586, 10.1074/jbc.271.12.6586 Sauane, 2000, Prostaglandin F(2alpha) (PGF(2alpha)) induces cyclin D1 expression and DNA synthesis via early signaling mechanisms in Swiss mouse 3T3 cells, Biochemical and Biophysical Research Communications, 270, 11, 10.1006/bbrc.2000.2383 Sawyer, 2002, Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2, British Journal of Pharmacology, 137, 1163, 10.1038/sj.bjp.0704973 Schwaner, 1995, Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL, Biochimica et Biophysica Acta, 1265, 8, 10.1016/0167-4889(94)00198-N Schwaner, 1992, The prostacyclin analogues, cicaprost and iloprost, increase cytosolic Ca2+ concentration in the human erythroleukemia cell line, HEL, via pertussis toxin-insensitive G-proteins, Eicosanoids, 5, S10 Sonnenburg, 1990, A prostaglandin E receptor coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rabbit cortical collecting tubule cell, The Journal of Biological Chemistry, 265, 8479, 10.1016/S0021-9258(19)38913-6 Spurney, 1993, Thromboxane binding and signal transduction in rat glomerular mesangial cells, American Journal of Physiology, 264, F292 Straus, 2000, 15-Deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway, Proceedings of the National Academy of Sciences of the United States of America, 97, 4844, 10.1073/pnas.97.9.4844 Tanabe, 1992, A family of metabotropic glutamate receptors, Neuron, 8, 169, 10.1016/0896-6273(92)90118-W Tang, 1995, Inhibition of TPA and 12(S)-HETE-stimulated tumor cell adhesion by prostacyclin and its stable analogs: Rationale for their antimetastatic effects, International Journal of Cancer, 60, 418, 10.1002/ijc.2910600325 Toh, 1995, Molecular evolution of receptors for eicosanoids, FEBS Letters, 361, 17, 10.1016/0014-5793(95)00129-W Tokuda, 1999, p42/p44 mitogen-activated protein kinase activation is involved in prostaglandin F2alpha-induced interleukin-6 synthesis in osteoblasts, Cellular Signalling, 11, 325, 10.1016/S0898-6568(98)00048-5 Tokuda, 1999, Prostaglandin D2 induces interleukin-6 synthesis via Ca2+ mobilization in osteoblasts: Regulation by protein kinase C, Prostaglandins, Leukotrienes, and Essential Fatty Acids, 61, 189, 10.1054/plef.1999.0089 Tontonoz, 1995, PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene, Molecular and Cellular Biology, 15, 351, 10.1128/MCB.15.1.351 Trist, 1989, The antagonism by BW A868C of PGD2 and BW245C activation of human platelet adenylate cyclase, British Journal of Pharmacology, 96, 301, 10.1111/j.1476-5381.1989.tb11817.x Tsubouchi, 2000, Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis, Biochemical and Biophysical Research Communications, 270, 400, 10.1006/bbrc.2000.2436 Tsushita, 1992, Proliferative effect of PGD2 on osteoblast-like cells; independent activation of pertussis toxin-sensitive GTP-binding protein from PGE2 or PGF2 alpha, Prostaglandins, Leukotrienes, and Essential Fatty Acids, 45, 267, 10.1016/0952-3278(92)90082-T Ushikubi, 1994, Functional reconstitution of platelet thromboxane A2 receptors with Gq and Gi2 in phospholipid vesicles, Molecular Pharmacology, 46, 808 Vassaux, 1993, Inhibition of prostacyclin-induced Ca2+ mobilization by phorbol esters in Ob1771 preadipocytes, Prostaglandins, 46, 441, 10.1016/0090-6980(93)90080-Q Versteeg, 2000, Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, phosphatidylinositol 3-kinase, and Rac, The Journal of Biological Chemistry, 275, 28750, 10.1074/jbc.M907635199 Versteeg, 2000, A new phosphospecific cell-based ELISA for p42/p44 mitogen-activated protein kinase (MAPK), p38 MAPK, protein kinase B and cAMP-response-element-binding protein, The Biochemical Journal, 350, 717, 10.1042/0264-6021:3500717 Versteeg, 1999, Cyclooxygenase-dependent signalling: Molecular events and consequences, FEBS Letters, 445, 1, 10.1016/S0014-5793(99)00105-2 von Euler, 1936, On specific vaso-dilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin), The Journal of Physiology, 88, 213, 10.1113/jphysiol.1936.sp003433 Walsh, 2000, The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for prostacyclin-mediated desensitization, The Journal of Biological Chemistry, 275, 20412, 10.1074/jbc.M907881199 Watabe, 1993, Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor, The Journal of Biological Chemistry, 268, 20175, 10.1016/S0021-9258(20)80710-8 Watanabe, 1996, Positive and negative regulation of cell proliferation through prostaglandin receptors in NIH-3T3 cells, Journal of Cellular Physiology, 169, 401, 10.1002/(SICI)1097-4652(199611)169:2<401::AID-JCP20>3.0.CO;2-A Watanabe, 1995, Prostaglandin F2 alpha stimulates formation of p21ras-GTP complex and mitogen-activated protein kinase in NIH-3T3 cells via Gq-protein-coupled pathway, The Journal of Biological Chemistry, 270, 8984, 10.1074/jbc.270.15.8984 Watanabe, 1991, Characterization of prostaglandin and thromboxane receptors expressed on a megakaryoblastic leukemia cell line, MEG-01s, Blood, 78, 2328, 10.1182/blood.V78.9.2328.2328 Williams, 1979, Prostaglandin E2, prostaglandin I2 and the vascular changes of inflammation, British Journal of Pharmacology, 65, 517, 10.1111/j.1476-5381.1979.tb07860.x Williams, 2000, Regulation of macrophage interleukin-6 (IL-6) and IL-10 expression by prostaglandin E2: The role of p38 mitogen-activated protein kinase, Journal of Interferon & Cytokine Research, 20, 291, 10.1089/107999000312423 Xie, 1992, Mitogen-inducible prostaglandin G/H synthase: A new target for nosteroidal anti-inflammatory drugs, Drugs Development Research, 25, 249, 10.1002/ddr.430250402 Yousufzai, 1994, Muscarinic stimulation of arachidonic acid release and prostaglandin synthesis in bovine ciliary muscle: Prostaglandins induce cyclic AMP formation and muscle relaxation, Experimental Eye Research, 58, 513, 10.1006/exer.1994.1045