Role of plant alkaloids on human health: A review of biological activities
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Jing, 2014, Histochemical investigation and kinds of alkaloids in leaves of different developmental stages in Thymus quinquecostatus, Sci. World J., 2014, 1, 10.1155/2014/839548
Arnason, 2005, Biodiversity & health: focusing research to policy
Acamovic, 2004
Aniszewski, 2007
Cordell, 1981
Debnath, 2015, Estimation of alkaloids and phenolics of five edible cucurbitaceous plants and their antibacterial activity, Int. J. Pharm. Pharmaceut. Sci., 7, 223
Pan, 2013, New perspectives on how to discover drugs from herbal medicines: CAM's outstanding contribution to modern therapeutics, Evid. Base Compl Alternative Med, 2013, 1
Benowitz, 2009, Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics, Annu. Rev. Pharmacol. Toxicol., 49, 57, 10.1146/annurev.pharmtox.48.113006.094742
Shah, 2010, 485
Nicotine Side Effects. Available at: https://www.drugs.com/sfx/nicotine-side-effects.html (Accessed 22 June 2015).
Cytisine. Technical tips online. Available at: https://www.drugs.com/dict/cytisine.html (Accessed 22 June 2016).
Pérez, 2012, Cytisine: a natural product leads for the development of drugs acting at nicotinic acetylcholine receptors, Nat. Prod. Rep., 29, 555, 10.1039/c2np00100d
Çaksen, 2003, Deadly nightshade (Atropa belladonna) intoxication: an analysis of 49 children, Hum. Exp. Toxicol., 22, 665, 10.1191/0960327103ht404oa
Tripathi, 2013
Robenshtok, 2002, Adverse reaction to atropine and the treatment of organophosphate intoxication, Isr. Med. Assoc. J., 4, 535
Lewis, 2003
Renner, 2005, Pharmacokinetics and pharmacodynamics in clinical use of scopolamine, Ther. Drug Monit., 27, 655, 10.1097/01.ftd.0000168293.48226.57
Transderm scop side effects center. Technical tips online. Available at: http://www.rxlist.com/transderm-scop-side-effects-drug-center.htm (Accessed 30 June 2016).
Plowman, 1984
1986
Campos, 2005, Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms, Psychopharmacology, 182, 45, 10.1007/s00213-005-0052-1
Zanolari, 2003, Tropane alkaloids from the bark of Erythroxylum vacciniifolium, J. Nat. Prod., 66, 497, 10.1021/np020512m
Catuabine. Available at: https://en.wikipedia.org/wiki/Catuabine (Accessed 10 July 2016).
Achan, 2011, Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria, Malar. J., 10, 144, 10.1186/1475-2875-10-144
Quinine. Available at: http://www.newworldencyclopedia.org/entry/Quinine (Accessed 14 July 2016).
White, 1981, Quinidine in falciparum malaria, Lancet, 318, 1069, 10.1016/S0140-6736(81)91275-7
Brembilla-Perrot, 1997, Relationships between heart rate variability and antiarrhythmic effects of hydroquinidine, Cardiovasc. Drugs Ther., 11, 493, 10.1023/A:1007709808576
Nontprasert, 1996, Antimalarial activity and interactions between quinine, dihydroquinine and 3-hydroxyquinine against Plasmodium falciparum in vitro, Trans. R. Soc. Trop. Med. Hyg., 90, 553, 10.1016/S0035-9203(96)90320-X
Curd, 1945, Studies on synthetic antimalarial drugs: II.—general chemical considerations, Ann. Trop. Med. Parasitol., 39, 157, 10.1080/00034983.1945.11685229
Shimizu, 2000, Mechanism of relaxant response to papaverine on the smooth muscle of non-pregnant rat uterus, J. Smooth Muscle Res., 36, 83, 10.1540/jsmr.36.83
Reynolds, 1974, Crystal and molecular structure of the alkaloid papaverine hydrochloride, J. Cryst. Mol. Struct., 4, 213, 10.1007/BF01198178
Triner, 1970, Cyclic phosphodiesterase activity and the action of papaverine, Biochem. Biophys. Res. Commun., 40, 64, 10.1016/0006-291X(70)91046-6
Srivastava, 2015, A review on biological and chemical diversity in Berberis (Berberidaceae), EXCLI J., 14, 247
Turner, 2008, Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action, Diabetes, 57, 1414, 10.2337/db07-1552
Han, 2012, Mechanisms involved in the cytotoxic effects of berberine on human colon cancer HCT-8 cells, Biocell, 36, 113
Chu, 2014, Role of berberine in anti-bacterial as a high-affinity LPS antagonist binding to TLR4/MD-2 receptor, BMC Compl. Alternative Med., 14, 1
Shanbhag, 1970, Pharmacological actions of berberine on the central nervous system, Jpn. J. Pharmacol., 20, 482, 10.1254/jjp.20.482
Amritpal, 2010, Berberine: alkaloid with wide spectrum of pharmacological activities, J. Nat. Prod.(India), 3, 64
Hoskin, 1991, Opioid agonist-antagonist drugs in acute and chronic pain states, Drugs, 41, 326, 10.2165/00003495-199141030-00002
Ma, 2007, Pharmacological effects of ephedrine alkaloids on human α1-and α2-adrenergic receptor subtypes, J. Pharmacol. Exp. Therapeut., 322, 214, 10.1124/jpet.107.120709
Frank, 1990, Hordenine: pharmacology, pharmacokinetics and behavioural effects in the horse, Equine Vet. J., 22, 437, 10.1111/j.2042-3306.1990.tb04312.x
Barwell, 1989, Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat, J. Pharm. Pharmacol., 41, 421, 10.1111/j.2042-7158.1989.tb06492.x
Garattini, 1961, Pharmacological and biochemical affects of some reserpine derivatives, J. Pharm. Pharmacol., 13, 548, 10.1111/j.2042-7158.1961.tb11868.x
Pharmacognosy ergotamine. http://www.epharmacognosy.com/2012/07/ergotamine-obtained-from-seeds-of.html (Accessed 22 May 2015).
Drug bank, ergotamine. https://www.drugbank.ca/drugs/DB00696 (Accessed 28 May 2015).
De Costa, 2002, St Anthony's fire and living ligatures: a short history of ergometrine, Lancet, 359, 1768, 10.1016/S0140-6736(02)08658-0
Votava, 1957, Pharmacological Studies of ergometrine and methylergometrine, Basic Clin. Pharmacol. Toxicol., 13, 309
Yohimbine Bark Extract. Available at: http://www.hnkeyuan.com/sports_nutrition/yohimbine-bark.html (Accessed 25 July 2016).
Pharmacology of Yohimbine. Available at: http://www.drugbank.ca/drugs/DB01392 (Accessed 25 July 2016).
Berlan, 1993, α2-Adrenoceptor antagonist potencies of two hydroxylated metabolites of yohimbine, Br. J. Pharmacol., 108, 927, 10.1111/j.1476-5381.1993.tb13488.x
Yohimbe Side Effect. Available at: https://www.drugs.com/sfx/yohimbe-side-effects.html. (Accessed 26 July 2016).
Moudi, 2013, Vinca alkaloids, Int. J. Prev. Med., 4, 1231
Vinblastine. Available at: http://www.drugbank.ca/drugs/DB00570 (Accessed 28 July 2016).
Vinblastine. Available at: https://www.drugs.com/pro/vinblastine.html (Accessed 28 July 2016).
Vinblastine Side Effects. Technical tips online. Available at: https://www.drugs.com/sfx/vinblastine-side-effects.html (Accessed 28 July 2016).
Vincristine. Available at http://www.drugbank.ca/drugs/DB00541 (Accessed 29 July 2016).
Ronghe, 2001, Remission induction therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of vincristine, corticosteroids, L-asparaginase and anthracyclines, Canc. Treat Rev., 27, 327, 10.1053/ctrv.2001.0243
Vincristine Side Effect. Technical tips online. Available at: https://www.drugs.com/sfx/vincristine-side-effects.htm (Accessed 29 July 2016).
Argyreia nervosa. Available at https://en.wikipedia.org/wiki/Argyreia_nervosa (Accessed 31 July 2016).
Paulke, 2013, Argyreia nervosa (Burm. f.): receptor profiling of lysergic acid amide and other potential psychedelic LSD-like compounds by computational and binding assay approaches, J. Ethnopharmacol., 148, 492, 10.1016/j.jep.2013.04.044
Rusconi, 2010, Theobroma cacao L., the Food of the Gods: a scientific approach beyond myths and claims, Pharmacol. Res., 61, 5, 10.1016/j.phrs.2009.08.008
Cappelletti, 2015, Caffeine: cognitive and physical performance enhancer or psychoactive drug?, Curr. Neuropharmacol., 13, 71, 10.2174/1570159X13666141210215655
Nehlig, 1992, Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects, Brain Res. Rev., 17, 139, 10.1016/0165-0173(92)90012-B
Benowitz, 1990, Clinical pharmacology of caffeine, Annu. Rev. Med., 41, 277, 10.1146/annurev.me.41.020190.001425
Santos, 2004, Pilocarpus spp.: a survey of its chemical constituents and biological activities, Rev. Bras. Ciencias Farm., 40, 116, 10.1590/S1516-93322004000200002
Reyes-Escogido, 2011, Chemical and pharmacological aspects of capsaicin, Molecules, 16, 1253, 10.3390/molecules16021253
Capsaicin Topical Side Effects. Available at: https://www.drugs.com/sfx/capsaicin-topical-side-effects.html (Accessed 2 Aug 2016).
Corbin, 2012, Choline metabolism provides novel insights into non-alcoholic fatty liver disease and its progression, Curr. Opin. Gastroenterol., 28, 159, 10.1097/MOG.0b013e32834e7b4b
Jacob, 2011, J. Chromatogr. B Anal. Technol. Biomed. Life Sci., 879, 267, 10.1016/j.jchromb.2010.12.012
Gorrod, 1993, 185
Astroug, 2010, Pharmacokinetics of cytisine after single intravenous and oral administration in rabbits, Interdiscipl. Toxicol., 3, 15, 10.2478/v10102-010-0003-5
Jeong, 2015, Pharmacokinetics of cytisine, an α4β2 nicotinic receptor partial agonist, in healthy smokers following a single dose, Drug Test. Anal., 7, 475, 10.1002/dta.1707
Atropine sulphate. Technical tips online. Available at: http://ratguide.com/meds/cardiovascular_drugs/atropine_sulfate.php (Accessed 30 June 2016).
Chen, 2005, Analysis of scopolamine and its eighteen metabolites in rat urine by liquid chromatography-tandem mass spectrometry, Talanta, 67, 984, 10.1016/j.talanta.2005.04.026
Chen, 2008, Liquid chromatography-electrospray ionization ion trap mass spectrometry for analysis of in vivo and in vitro metabolites of scopolamine in rats, J. Chromatogr. Sci., 46, 74, 10.1093/chromsci/46.1.74
Kolbrich, 2006, Major and minor metabolites of cocaine in human plasma following controlled subcutaneous cocaine administration, J. Anal. Toxicol., 30, 501, 10.1093/jat/30.8.501
Mirghani, 2003, Metabolism and elimination of quinine in healthy volunteers, Eur. J. Clin. Pharmacol., 59, 423, 10.1007/s00228-003-0637-8
Rakhit, 1984, Pharmacokinetics of quinidine and three of its metabolites in man, J. Pharmacokinet. Pharmacodyn., 12, 1, 10.1007/BF01063608
Nielsen, 1999, In vitro metabolism of quinidine: the (3S)-3-hydroxylation of quinidine is a specific marker reaction for cytochrome P-4503A4 activity in human liver microsomes, J. Pharmacol. Exp. Therapeut., 289, 31
Ebert, 1998, Female gender as a risk factor for drug-induced cardiac arrhythmias: evaluation of clinical and experimental evidence, J. Womens Health, 7, 547, 10.1089/jwh.1998.7.547
Peng, 2007, Chromatographic tandam mass spectrometric detection of papaverine and its major metabolites in rat urine, Int. J. Mass Spectrom., 266, 114, 10.1016/j.ijms.2007.07.013
Zuo, 2006, Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry, Drug Metab. Dispos., 34, 2064, 10.1124/dmd.106.011361
Codeine and Morphine Pathway, Pharmacokinetics. Available at: https://www.pharmgkb.org/pathway/PA146123006 (Accessed 22 July 2015).
Bovill, 1997, Mechanisms of actions of opioids and non-steroidal anti-inflammatory drugs, Eur. J. Anaesthesiol., 14, 9, 10.1097/00003643-199705001-00003
Tseng, 2006, Metabolites of ephedrines in human urine after administration of a single therapeutic dose, Forensic Sci. Int., 157, 149, 10.1016/j.forsciint.2005.04.008
Bollina, 2010, Mass spectrometry-based metabolomics application to identify quantitative resistance-related metabolites in barley against Fusarium head blight, Mol. Plant Pathol., 11, 769
Glazko, 1956, Studies on the metabolism of reserpine, J. Pharmacol. Exp. Therapeut., 118, 377
Drugbank, Ergotamine. Available at: https://www.drugbank.ca/drugs/DB00696 (Accessed 23 July 2016).
Duringer, 2005, Growth and hepatic in vitro metabolism of ergotamine in mice divergently selected for response to endophyte toxicity, Xenobiotica, 35, 531, 10.1080/00498250500153838
Le Verge, 1992, Determination of yohimbine and its two hydroxylated metabolites in humans by high-performance liquid chromatography and mass spectral analysis, J. Chromatogr. B Biomed. Sci. Appl., 574, 283, 10.1016/0378-4347(92)80041-N
Le Corre, 1999, Biopharmaceutics and metabolism of yohimbine in humans, Eur. J. Pharmaceut. Sci., 9, 79, 10.1016/S0928-0987(99)00046-9
Tellingen, 1993, Tissue disposition, excretion and metabolism of vinblastine in mice as determined by high-performance liquid chromatography, Canc. Chemother. Pharmacol., 32, 286, 10.1007/BF00686174
Dennison, 2006, Selective metabolism of vincristine in vitro by CYP3A5, Drug Metab. Dispos., 34, 1317, 10.1124/dmd.106.009902
Dennison, 2007
Eteng, 1997, Recent advances in caffeine and theobromine toxicities: a review, Plant Foods Hum. Nutr., 51, 231, 10.1023/A:1007976831684
Hioki, 2011, Human paraoxonase 1 is the enzyme responsible for pilocarpine hydrolysis, Drug Metab. Dispos., 39, 1345, 10.1124/dmd.111.038141
Chanda, 2008, In vitro hepatic and skin metabolism of capsaicin, Drug Metab. Dispos., 36, 670, 10.1124/dmd.107.019240
Choline. Available at: http://lpi.oregonstate.edu/mic/other-nutrients/choline (Accessed 4 Aug 2016).
Manske, 1960, vol. I
Lewis, 2003
O'Hagan, 2000, Pyrrole, pyrrolidine, pyridine, piperidine and tropane alkaloids, Nat. Prod. Rep., 17, 435, 10.1039/a707613d
Singh, 2010, Biological activities of Withania somnifera, Ann. Biol. Res., 1, 56
Kar, 2003, 489
Mansurov, 1971, The effect of stachydrine alkaloid on the blood coagulation system, Farmakol. Toksikol., 35, 715
Rathee, 2012, In vitro anticancer activity of stachydrine isolated from Capparis decidua on prostate cancer cell lines, Nat. Prod. Res., 26, 1737, 10.1080/14786419.2011.608673
Schmeller, 1997, Allelochemical activities of pyrrolizidine alkaloids: interactions with neuroreceptors and acetylcholine related enzymes, J. Chem. Ecol., 23, 399, 10.1023/B:JOEC.0000006367.51215.88
Euler, 1945, Nicotine-like actions of arecoline, Basic Clin. Pharmacol. Toxicol., 1, 263
Holmstedt, 1967, Arecoline, nicotine, and related compounds. Tremorgenic activity and effect upon brain acetylcholine, Ann. N. Y. Acad. Sci., 142, 126, 10.1111/j.1749-6632.1967.tb13719.x
Chandra, 2008, Effect of novel arecoline thiazolidinones as muscarinic receptor 1 agonist in Alzheimer's dementia models, Neurochem. Int., 52, 376, 10.1016/j.neuint.2007.07.006
Chang, 2007, Arecoline inhibits the 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced cytochrome P450 1A1 activation in human hepatoma cells, J. Hazard Mater., 146, 356, 10.1016/j.jhazmat.2006.12.035
Garg, 2014, A review of the systemic adverse effects of areca nut or betel nut, Indian J. Med. Paediatr. Oncol., 35, 3, 10.4103/0971-5851.133702
France, 2004, vol. 85, 160
Patel, 2016, Medicinal significance, pharmacological activities, and analytical aspects of ricinine: a concise report, J. Coast. Life Med., 4, 663, 10.12980/jclm.4.2016J6-96
Ferraz, 1999, Pharmacological evaluation of ricinine, a central nervous system stimulant isolated from Ricinus communis, Pharmacol. Biochem. Behav., 63, 367, 10.1016/S0091-3057(99)00007-6
Jena, 2012, Ricinus communis Linn: a phytopharmacological review, Int. J. Pharm. Pharmaceut. Sci., 4, 25
Nath, 2011, Restorative aspect of castor plant on mammalian physiology: a review, J. Microbiol. Biotechnol. Food Sci., 1, 236
Hamelin, 2012, Evaluation of ricinine, a ricin biomarker, from a non-lethal castor bean ingestion, J. Anal. Toxicol., 36, 660, 10.1093/jat/bks077
Ferraz, 2000, Ricinine-elicited seizures: a novel chemical model of convulsive seizures, Pharmacol. Biochem. Behav., 65, 577, 10.1016/S0091-3057(99)00250-6
Cheeke, 1989
Green, 2013, Fetal muscle-type nicotinic acetylcholine receptor activation in TE-671 cells and inhibition of fetal movement in a day 40 pregnant goat model by optical isomers of the piperidine alkaloid coniine, J. Pharmacol. Exp. Therapeut., 344, 295, 10.1124/jpet.112.199588
Bowman, 1963, Pharmacological actions of hemlock (Conium maculatum) alkaloids, J. Pharm. Pharmacol., 15, 1, 10.1111/j.2042-7158.1963.tb12738.x
Vetter, 2004, Poison hemlock (Conium maculatum L.), Food Chem. Toxicol., 30, 1373, 10.1016/j.fct.2004.04.009
Bevan, 1962, Action of lobeline and capsaicine on afferent endings in the pulmonary artery of the cat, Circ. Res., 10, 792, 10.1161/01.RES.10.5.792
Daniel, 2006, 39
Quin, 2010
Seigler, 2002
Ecgonine. Available at: https://www.drugs.com/dict/ecgonine.html (Accessed 18 Aug 2015).
Pharmacognosy, Ecgonine. Technical tips online. Available at: http://www.epharmacognosy.com/2012/07/ecgonine-obtained-from-leaves-of.html (Accessed 18 Aug 2016).
Novak, 1984, Biological activity of the alkaloids of Erythroxylum coca and Erythroxylum novogranatense, J. Ethnopharmacol., 10, 261, 10.1016/0378-8741(84)90015-1
Tu, 1988, Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris, J. Pharm. Sci., 77, 461, 10.1002/jps.2600770522
Blumenthal, 1998
Dorling, 1983, The biological activity of swainsonine: an indolizidine alkaloid isolated from Swainsona canescens, Toxicon, 21, 93, 10.1016/0041-0101(83)90163-0
Sim, 1997, Analysis of swainsonine and its early metabolic precursors in cultures of Metarhizium anisopliae, Glycoconj. J., 14, 661, 10.1023/A:1018505130422
Strychnine-found in the Seeds of Strychnos Nux Vomica. Available at: http://www.epharmacognosy.com/2012/07/strychnine-found-in-seeds-of-strychnos.html (Accessed 18 Aug 2016).
Shapovalov, 1963, Effect of strychnine on activity of motor and internuncial neurons of the spinal cord during stimulation of the anterior lobe of the cerebellum, Bull. Exp. Biol. Med., 56, 1295, 10.1007/BF00784027
Churchill, 1984, Action and mechanism of action of veratrine on renin secretion from rat kidney slices, J. Pharmacol. Exp. Therapeut., 229, 27
Matsuda, 1989, Veratrine-induced decrease of (Na++ K+)-adenosine triphosphatase activity in rat brain slices, J. Pharmacol. Exp. Therapeut., 248, 729
Yin, 2003, Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica, J. Ethnopharmacol., 88, 205, 10.1016/S0378-8741(03)00224-1
Souto, 2011, Anti-inflammatory activity of alkaloids: an update from 2000 to 2010, Molecules, 16, 8515, 10.3390/molecules16108515
Chen, 2014, Pharmacological evaluation of total alkaloids from nux vomica: effect of reducing strychnine contents, Molecules, 19, 4395, 10.3390/molecules19044395
Deng, 2006, The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism, J. Ethnopharmacol., 106, 179, 10.1016/j.jep.2005.12.021
Malikova, 2006, Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis, Biomed. Pap. Palacky Univ. Olomouc, 150, 5, 10.5507/bp.2006.001
Akinboye, 2011, Biological activities of emetine, Open Nat. Prod. J., 4, 8, 10.2174/1874848101104010008
Verlee, 2011, Summary of NHG practice guideline 'Acute cough', Ned. Tijdschr. Geneeskd., 156, A4188
Narceine. Available at: https://en.wikipedia.org/wiki/Narceine (Accessed 2 Sep 2016).
Narceine. Available at: https://www.drugs.com/search.php?searchterm=narceine (Accessed 2 Sep 2016).
Liu, 1991, Studies on plant resources, pharmacology and clinical treatment with berbamine, Phytother. Res., 5, 228, 10.1002/ptr.2650050508
Xie, 2009, Berbamine derivatives: a novel class of compounds for anti-leukemia activity, Eur. J. Med. Chem., 44, 3293, 10.1016/j.ejmech.2009.02.018
Liang, 2009, Berbamine, a novel nuclear factor κB inhibitor, inhibits growth and induces apoptosis in human myeloma cells, Acta Pharmacol. Sin., 30, 1659, 10.1038/aps.2009.167
Griffin, 2011, Pancratistatin selectively targets cancer cell mitochondria and reduces growth of human colon tumor xenografts, Mol. Canc. Therapeut., 10, 57, 10.1158/1535-7163.MCT-10-0735
Ingrassia, 2008, Amaryllidaceae isocarbostyril alkaloids and their derivatives as promising antitumor agents, Transl. Oncol., 1, 1, 10.1593/tlo.08100
McLachlan, 2005, Pancratistatin: a natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis, Apoptosis, 10, 619, 10.1007/s10495-005-1896-x
Bezakova, 1996, Lipoxygenase inhibition and antioxidant properties of bisbenzylisoqunoline alkaloids isolated from Mahonia aquifolium, Pharmazie, 51, 758
Aceto, 1999, Stereoselective μ-and δ-opioid receptor-related antinociception and binding with (+)-thebaine, Eur. J. Pharmacol., 365, 143, 10.1016/S0014-2999(98)00862-0
Kovacic, 2009, Novel, unifying mechanism for mescaline in the central nervous system: electrochemistry, catechol redox metabolite, receptor, cell signaling and structure activity relationships, Oxid. Med. Cell. Longev., 2, 181, 10.4161/oxim.2.4.9380
Mescaline. Technical tips online. Available at: http://www.drugs.com/illicit/mescaline.html (Accessed 6 Sep 2016).
Bufotenine. Available at: https://www.britannica.com/science/bufotenine (Accessed 6 Sep 2016).
Passie, 2002, The pharmacology of psilocybin, Addict. Biol., 7, 357, 10.1080/1355621021000005937
Passie, 2008, The pharmacology of lysergic acid diethylamide: a review, CNS Neurosci. Ther., 14, 295, 10.1111/j.1755-5949.2008.00059.x
Shamima, 2012, Antinociceptive action of isolated mitragynine from Mitragyna speciosa through activation of opioid receptor system, Int. J. Mol. Sci., 13, 11427, 10.3390/ijms130911427
Hanapi, 2013, Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities, Pharmacogn. Res., 5, 241, 10.4103/0974-8490.118806
Takayama, 2002, Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands, J. Med. Chem., 25, 45
Matsumoto, 2004, Antinociceptive effect of 7-hydroxymitragynine in mice: discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa, Life Sci., 74, 2143, 10.1016/j.lfs.2003.09.054
Nicola, 2013, Chemical constituents antioxidant and anticholinesterasic activity of Tabernaemontana catharinensis, Sci. World J., 10.1155/2013/519858
Rizo, 2013, Cytotoxicity and genotoxicity of coronaridine from Tabernaemontana catharinensis A. DC in a human laryngeal epithelial carcinoma cell line (Hep-2), Genet. Mol. Biol., 36, 105, 10.1590/S1415-47572013005000010
Alper, 2001, Ibogaine: a review. The alkaloids:, Chem. Biol., 56, 1
Xu, 2000, A dose-response study of ibogaine-induced neuropathology in the rat cerebellum, Toxicol. Sci., 57, 95, 10.1093/toxsci/57.1.95
Koenig, 2015, The anti-addiction drug ibogaine and the heart: a delicate relation, Molecules, 20, 2208, 10.3390/molecules20022208
Mehta, 2013, Pharmacognosy and health benefits of cocoa seeds (chocolate), Notes Phcog., 6, 2013
Usmani, 2005, Theobromine inhibits sensory nerve activation and cough, Faseb. J., 19, 231, 10.1096/fj.04-1990fje
Phytochemicals. http://www.phytochemicals.info/phytochemicals/theophylline.php (Accessed 25 Jan 2016).
Salihović, 2014, DFT study and biological activity of some methylxanthines, Bull. Chem. Technol. Bosnia Herzeg, 42, 31
Gutser, 1997, Mode of antinociceptive and toxic action of alkaloids of Aconitum spec, Naunyn-Schmiedeberg's Arch. Pharmacol., 357, 39, 10.1007/PL00005136
Anwar, 2003, Biological and pharmacological properties of Aconitum chasmanthum, J. Biol. Sci., 3, 989
Pelletier, 1999
Roy, 1958, Kurchi alkaloids: their isolation, constitution & biological activity, J. Sci. Ind. Res., 71A, 158
Ballal, 2000, Antibacterial activity of Holarrhena antidysenterica [Kurchi] against the enteric pathogens, Indian J. Pharmacol., 32, 392
Kavitha, 2004, Antibacterial and antidiarrhoeal effects of alkaloids of Holarrhena antidysenterica WALL, Indian J. Exp. Biol., 42, 589
Santora, 2008, A new family of H 3 receptor antagonists based on the natural product Conessine, Bioorg. Med. Chem. Lett, 18, 1490, 10.1016/j.bmcl.2007.12.059
Esser, 1996, vol. VI
Velez, 2012, Biological characterization of Cynara cardunculus L. methanolic extracts: antioxidant, anti-proliferative, anti-migratory and anti-angiogenic activities, Agriculture, 2, 472, 10.3390/agriculture2040472
Cermanova, 2015, Boldine enhances bile production in rats via osmotic and Farnesoid X receptor dependent mechanisms, Toxicol. Appl. Pharmacol., 285, 12, 10.1016/j.taap.2015.03.004
Speisky, 1994, Boldo and boldine: an emerging case of natural drug development, Pharmacol. Res., 29, 1, 10.1016/1043-6618(94)80093-6
Zhang, 2007, Advances in development of dopaminergic aporphinoids, J. Med. Chem., 50, 171, 10.1021/jm060959i
Eich, 2008
Burnet, 2000, The stachydrine catabolism region in Sinorhizobium meliloti encodes a multi-enzyme complex similar to the xenobiotic degrading systems in other bacteria, Gene, 244, 151, 10.1016/S0378-1119(99)00554-5
Zhou, 2007, Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update, Curr. Drug Metabol., 8, 526, 10.2174/138920007781368863
Skoneczny, 2015, Metabolic profiling of pyrrolizidine alkaloids in foliage of two Echium spp. Invaders in Australia—a case of novel weapons?, Int. J. Mol. Sci., 16, 26721, 10.3390/ijms161125979
Peng, 2014, A metabonomic analysis of serum from rats treated with ricinine using ultra performance liquid chromatography coupled with mass spectrometry, PLoS One, 9
Langford, 1996, Oleander toxicity: an examination of human and animal toxic exposures, Toxicology, 109, 1, 10.1016/0300-483X(95)03296-R
Song, 2008, Identification of metabolites of lobeline in the rat urine by liquid chromatography–tandem mass spectrometry, Int. J. Mass Spectrom., 269, 131, 10.1016/j.ijms.2007.09.015
Moncrieff, 1990, Simultaneous determination of sparteine and its 2-dehydro and 5-dehydro metabolites in urine by high-performance liquid chromatography with electrochemical detection, J. Chromatogr. B Biomed. Sci. Appl., 529, 194, 10.1016/S0378-4347(00)83822-0
Ebner, 1995, Mechanism of cytochrome P450 2D6-catalyzed sparteine metabolism in humans, Mol. Pharmacol., 48, 1078
Xiong, 2009, Identification of metabolites of adonifoline, a hepatotoxic pyrrolizidine alkaloid, by liquid chromatography/tandem and high-resolution mass spectrometry, Rapid Commun. Mass Spectrom., 23, 3907, 10.1002/rcm.4329
Abraham, 1983, Swainsonine affects the processing of glycoproteins in vivo, FEBS Lett., 163, 110, 10.1016/0014-5793(83)81174-0
Mishima, 1985, Metabolism of strychnine in vitro, Drug Metab. Dispos., 13, 716
Chen, 2012, Simultaneous analysis of strychnine and brucine and their major metabolites by liquid chromatography–electrospray ion trap mass spectrometry, J. Anal. Toxicol., 36, 171, 10.1093/jat/bks004
Tian, 2014, Metabolism of brucine: the important metabolic pathways of dihydroindole-type alkaloid for excretion in rats, Bioanalysis, 6, 137, 10.4155/bio.13.290
Dvorak, 2007, Metabolism of sanguinarine: the facts and the myths, Curr. Drug Metabol., 8, 173, 10.2174/138920007779815959
Asano, 2001, Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities, Biol. Pharm. Bull., 24, 678, 10.1248/bpb.24.678
Asano, 2002, Biotransformation of the ipecac alkaloids cephaeline and emetine from ipecac syrup in rats, Eur. J. Drug Metab. Pharmacokinet., 27, 29, 10.1007/BF03190402
Tsunoda, 1979, Metabolic fate of noscapine. II. Isolation and identification of novel metabolites produced by C-C bond cleavage, Xenobiotica, 9, 181, 10.3109/00498257909038719
Misra, 1974, Pharmacokinetics and metabolism of [3H] thebaine, Xenobiotica, 4, 17, 10.3109/00498257409052087
Smith, 2009, Opioid metabolism, Mayo Clin. Proc., 84, 613, 10.1016/S0025-6196(11)60750-7
Charalampous, 1966, Metabolic fate of mescaline in man, Psychopharmacology, 9, 48, 10.1007/BF00427703
Sanders, 1967, Distribution, metabolism and excretion of bufotenine in the rat with preliminary studies of its O-methyl derivative, J. Pharmacol. Exp. Therapeut., 158, 340
Philipp, 2009, Studies on the metabolism of mitragynine, the main alkaloid of the herbal drug Kratom, in rat and human urine using liquid chromatography-linear ion trap mass spectrometry, J. Mass Spectrom., 44, 1249, 10.1002/jms.1607
Zhang, 2005, Separation and identification of Aconitum alkaloids and their metabolites in human urine, Toxicon, 46, 500, 10.1016/j.toxicon.2005.06.014
Lyu, 2015, Identification and characterization of in vitro and in vivo metabolites of steroidal alkaloid veratramine, Biopharm. Drug Dispos., 36, 308, 10.1002/bdd.1942
Hroch, 2013, Development of an HPLC fluorescence method for determination of boldine in plasma, bile and urine of rats and identification of its major metabolites by LC–MS/MS, J. Chromatogr. B, 936, 48, 10.1016/j.jchromb.2013.07.009
Kubinova, 2001, Chemoprotective activity of boldine: modulation of drug-metabolizing enzymes, Die Pharmazie, 56, 242