Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing

Nature - Tập 439 Số 7075 - Trang 430-436 - 2006
Dolors Ferrés-Marcó1, Irene Gutiérrez-García1, Diana M. Vallejo1, Jorge Bolı́var2, Francisco José Gutiérrez-Aviñó1, María Domínguez1
1Instituto de Neurociencias CSIC–UMH, Campus de San Juan, Apartado 18, 03550, Sant Joan, Alicante, Spain
2Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Cadiz, Poligono Rio San Pedro s/n, 11510, Puerto Real, Spain

Tóm tắt

Từ khóa


Tài liệu tham khảo

Logan, C. Y. & Nusse, R. The Wnt signalling pathway in development and disease. Annu. Rev. Cell. Dev. Biol. 20, 781–810 (2004)

Hooper, J. E. & Scott, M. P. Communicating with Hedgehogs. Nature Rev. Mol. Cell Biol. 6, 306–317 (2005)

Artavanis-Tsakonas, S., Rand, M. D. & Lake, R. J. Notch signalling: cell fate control and signal integration in development. Science 284, 770–776 (1999)

Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100, 57–70 (2000)

Taipale, J. & Beachy, P. A. The Hedgehog and Wnt signalling pathways in cancer. Nature 411, 349–354 (2001)

Allenspach, E. J., Maillard, I., Aster, J. C. & Pear, W. S. Notch signalling in cancer. Cancer Biol. Ther. 1, 466–476 (2002)

Lund, A. H. & van Lohuizen, M. Epigenetics and cancer. Genes Dev. 18, 2315–2335 (2004)

Valk-Lingbeek, M. E., Bruggeman, S. W. & van Lohuizen, M. Stem cells and cancer; the polycomb connection. Cell 118, 409–418 (2004)

Ringrose, L. & Paro, R. Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu. Rev. Genet. 38, 413–443 (2004)

Cao, R. & Zhang, Y. The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr. Opin. Genet. Dev. 14, 155–164 (2004)

Nguyen, C. T. et al. Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2′-deoxycytidine. Cancer Res. 62, 6456–6461 (2002)

Lachner, M., O'Sullivan, R. J. & Jenuwein, T. An epigenetic road map for histone lysine methylation. J. Cell Sci. 116, 2117–2124 (2003)

Feinberg, A. P. & Tycko, B. The history of cancer epigenetics. Nature Rev. Cancer 4, 143–153 (2004)

Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell 81, 323–330 (1995)

Woodhouse, E. C. & Liotta, L. A. Drosophila invasive tumors: a model for understanding metastasis. Cell Cycle 3, 38–40 (2004)

Dominguez, M. & Casares, F. Organ specification-growth control connection: new insights from the Drosophila eye-antennal disc. Dev. Dyn. 232, 673–684 (2005)

Toba, G. et al. The gene search system. A method for efficient detection and rapid molecular identification of genes in Drosophila melanogaster. Genetics 151, 725–737 (1999)

Dominguez, M. & de Celis, J. F. A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye. Nature 396, 276–278 (1998)

Giniger, E., Tietje, K., Jan, L. Y. & Jan, Y. N. lola encodes a putative transcription factor required for axon growth and guidance in Drosophila. Development 120, 1385–1398 (1994)

Madden, K., Crowner, D. & Giniger, E. LOLA has the properties of a master regulator of axon-target interaction for SNb motor axons of Drosophila. Dev. Biol. 213, 301–313 (1999)

Goeke, S. et al. Alternative splicing of lola generates 19 transcription factors controlling axon guidance in Drosophila. Nature Neurosci 6, 917–924 (2003)

Ohsako, T., Horiuchi, T., Matsuo, T., Komaya, S. & Aigaki, T. Drosophila lola encodes a family of BTB-transcription regulators with highly variable C-terminal domains containing zinc finger motifs. Gene 311, 59–69 (2003)

Horowitz, H. & Berg, C. A. The Drosophila pipsqueak gene encodes a nuclear BTB-domain-containing protein required early in oogenesis. Development 122, 1859–1871 (1996)

Weber, U., Siegel, V. & Mlodzik, M. pipsqueak encodes a novel nuclear protein required downstream of seven-up for the development of photoreceptors R3 and R4. EMBO J. 14, 6247–6257 (1995)

Siegmund, T. & Lehmann, M. The Drosophila Pipsqueak protein defines a new family of helix-turn-helix DNA-binding proteins. Dev. Genes Evol. 212, 152–157 (2002)

Siegel, V., Jongens, T. A., Jan, L. Y. & Jan, Y. N. pipsqueak, an early acting member of the posterior group of genes, affects vasa level and germ cell-somatic cell interaction in the developing egg chamber. Development 119, 1187–1202 (1993)

Lehmann, M., Siegmund, T., Lintermann, K. G. & Korge, G. The pipsqueak protein of Drosophila melanogaster binds to GAGA sequences through a novel DNA-binding domain. J. Biol. Chem. 273, 28504–28509 (1998)

Schwendemann, A. & Lehmann, M. Pipsqueak and GAGA factor act in concert as partners at homeotic and many other loci. Proc. Natl Acad. Sci. USA 99, 12883–12888 (2002)

Rorth, P. et al. Systematic gain-of-function genetics in Drosophila. Development 125, 1049–1057 (1998)

Barna, M. et al. Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling. Dev. Cell 3, 499–510 (2002)

Melnick, A. et al. Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors. Mol. Cell Biol. 22, 1804–1818 (2002)

Schotta, G. et al. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 18, 1251–1262 (2004)

Irvine, K. D. Fringe, Notch, and making developmental boundaries. Curr. Opin. Genet. Dev. 9, 434–441 (1999)

Dominguez, M., Ferres-Marco, D., Gutierrez-Avino, F. J., Speicher, S. A. & Beneyto, M. Growth and specification of the eye are controlled independently by Eyegone and Eyeless in Drosophila melanogaster. Nature Genet. 36, 31–39 (2004)

Chao, J. L., Tsai, Y. C., Chiu, S. J. & Sun, Y. H. Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye. Development 131, 3839–3847 (2004)

Bray, S., Musisi, H. & Bienz, M. Bre1 is required for Notch signalling and histone modification. Dev. Cell 8, 279–286 (2005)

Muller, J. et al. Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111, 197–208 (2002)

Tie, F., Furuyama, T., Prasad-Sinha, J., Jane, E. & Harte, P. J. The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3. Development 128, 275–286 (2001)

Czermin, B. et al. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111, 185–196 (2002)

Janody, F. et al. A mosaic genetic screen reveals distinct roles for trithorax and polycomb group genes in Drosophila eye development. Genetics 166, 187–200 (2004)

Harbour, J. W. & Dean, D. C. The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev. 14, 2393–2409 (2000)

Gowher, H., Leismann, O. & Jeltsch, A. DNA of Drosophila melanogaster contains 5-methylcytosine. EMBO J. 19, 6918–6923 (2000)

Jabbari, K. & Bernardi, G. Cytosine methylation and CpG, TpG (CpA) and TpA frequencies. Gene 333, 143–149 (2004)

Salzberg, A., Fisher, O., Siman-Tov, R. & Ankri, S. Identification of methylated sequences in genomic DNA of adult Drosophila melanogaster. Biochem. Biophys. Res. Commun. 322, 465–469 (2004)

Kunert, N., Marhold, J., Stanke, J., Stach, D. & Lyko, F. A Dnmt2-like protein mediates DNA methylation in Drosophila. Development 130, 5083–5090 (2003)

Hung, M. S. et al. Drosophila proteins related to vertebrate DNA (5-cytosine) methyltransferases. Proc. Natl Acad. Sci. USA 96, 11940–11945 (1999)

Narsa Reddy, M., Tang, L. Y., Lee, T. L. & James Shen, C. K. A candidate gene for Drosophila genome methylation. Oncogene 22, 6301–6303 (2003)

Marhold, J., Kramer, K., Kremmer, E. & Lyko, F. The Drosophila MBD2/3 protein mediates interactions between the MI-2 chromatin complex and CpT/A-methylated DNA. Development 131, 6033–6039 (2004)

Baonza, A. & Freeman, M. Control of cell proliferation in the Drosophila eye by notch signalling. Dev. Cell 8, 529–539 (2005)

Firth, L. C. & Baker, N. E. Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev. Cell 8, 541–551 (2005)