High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): an open, phase 4, randomised controlled trial

Manley, 2013, High-flow nasal cannulae in very preterm infants after extubation, N Engl J Med, 369, 1425, 10.1056/NEJMoa1300071 Schibler, 2011, Reduced intubation rates for infants after introduction of high-flow nasal prong oxygen delivery, Intensive Care Med, 37, 847, 10.1007/s00134-011-2177-5 McKiernan, 2010, High flow nasal cannulae therapy in infants with bronchiolitis, J Pediatr, 156, 634, 10.1016/j.jpeds.2009.10.039 Beggs, 2014, High-flow nasal cannula therapy for infants with bronchiolitis, Cochrane Database Syst Rev, 1, 10.1002/14651858.CD009609.pub2 Mayfield, 2014, High-flow nasal cannula therapy for respiratory support in children, Cochrane Database Syst Rev, 3 Collins, 2013, A randomized controlled trial to compare heated humidified high-flow nasal cannulae with nasal continuous positive airway pressure postextubation in premature infants, J Pediatr, 162, 949, 10.1016/j.jpeds.2012.11.016 Frat, 2015, High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure, N Engl J Med, 372, 2185, 10.1056/NEJMoa1503326 Stéphan, 2015, High-flow nasal oxygen vs noninvasive positive airway pressure in hypoxemic patients after cardiothoracic surgery: a randomized clinical trial, JAMA, 313, 2331, 10.1001/jama.2015.5213 Mayfield, 2014, High-flow nasal cannula oxygen therapy for infants with bronchiolitis: pilot study, J Pediatrics Child Health, 50, 373, 10.1111/jpc.12509 Hough, 2012, Humidified high flow nasal cannulae: current practice in Australasian nurseries, a survey, J Pediatr Child Health, 48, 106, 10.1111/j.1440-1754.2011.02070.x Haq, 2014, The evidence for high flow nasal cannula devices in infants, Pediatr Respir Rev, 15, 124 Manley, 2012, High-flow nasal cannulae for respiratory support of preterm infants: a review of the evidence, Neonatology, 102, 300, 10.1159/000341754 Chisti, 2015, Bubble continuous positive airway pressure for children with severe pneumonia and hypoxaemia in Bangladesh: an open, randomised controlled trial, Lancet, 386, 1057, 10.1016/S0140-6736(15)60249-5 Zwarenstein, 2008, Improving the reporting of pragmatic trials: an extension of the CONSORT statement, BMJ, 337, a2390, 10.1136/bmj.a2390 2012 Meissner, 2016, Viral bronchiolitis in children, N Engl J Med, 374, 10, 10.1056/NEJMra1413456 Ralston, 2014, Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis, Pediatrics, 134, e1474, 10.1542/peds.2014-2742 Wettstein, 2005, Delivered oxygen concentrations using low-flow and high-flow nasal cannulas, Respir Care, 50, 604 Jubran, 1999, Pulse oximetry, Crit Care, 3, R11, 10.1186/cc341 Suiter, 2007, Oxygen saturation and heart rate during feeding in breast-fed infants at 1 week and 2 months of age, Arch Phys Med Rehabil, 88, 1681, 10.1016/j.apmr.2007.07.042 2011 Welliver, 2003, Review of epidemiology and clinical risk factors for severe respiratory syncytial virus (RSV) infection, J Pediatr, 143, 112, 10.1067/S0022-3476(03)00508-0 2015 Cunningham, 2016, Deciphering clinical phenotypes in acute viral lower respiratory tract infection: bronchiolitis is not an island, Thorax, 71, 679, 10.1136/thoraxjnl-2016-209012 2006 Duarte-Dorado, 2013, Validation of a scale to assess the severity of bronchiolitis in a population of hospitalized infants, J Asthma, 50, 1056, 10.3109/02770903.2013.834504 Piedra Schuh, 2014, Effect of oximetry on hospitalization in bronchiolitis: a randomized clinical trial, JAMA, 312, 712, 10.1001/jama.2014.8637 Cunningham, 2015, Oxygen saturation targets in infants with bronchiolitis (BIDS): a double-blind, randomised, equivalence trial, Lancet, 368, 1041, 10.1016/S0140-6736(15)00163-4