SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning

Biederer, 2006, Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules, Genomics, 87, 139, 10.1016/j.ygeno.2005.08.017 Biederer, 2002, SynCAM, a synaptic adhesion molecule that drives synapse assembly, Science, 297, 1525, 10.1126/science.1072356 Biederer, 2008, Signaling by synaptogenic molecules, Curr. Opin. Neurobiol., 18, 261, 10.1016/j.conb.2008.07.014 Blundell, 2010, Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior, J. Neurosci., 30, 2115, 10.1523/JNEUROSCI.4517-09.2010 Bourgeron, 2009, A synaptic trek to autism, Curr. Opin. Neurobiol., 19, 231, 10.1016/j.conb.2009.06.003 Cheng, 2006, Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum, Mol. Cell. Proteomics, 5, 1158, 10.1074/mcp.D500009-MCP200 Chih, 2005, Control of excitatory and inhibitory synapse formation by neuroligins, Science, 307, 1324, 10.1126/science.1107470 Chubykin, 2007, Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2, Neuron, 54, 919, 10.1016/j.neuron.2007.05.029 Davis, 1997, Genetic analysis of the mechanisms controlling target selection: Target-derived Fasciclin II regulates the pattern of synapse formation, Neuron, 19, 561, 10.1016/S0896-6273(00)80372-4 Fiala, 2002, Dendritic spine pathology: Cause or consequence of neurological disorders?, Brain Res. Brain Res. Rev., 39, 29, 10.1016/S0165-0173(02)00158-3 Fogel, 2007, SynCAMs organize synapses through heterophilic adhesion, J. Neurosci., 27, 12516, 10.1523/JNEUROSCI.2739-07.2007 Fujita, 2006, Oligo-astheno-teratozoospermia in mice lacking RA175/TSLC1/SynCAM/IGSF4A, a cell adhesion molecule in the immunoglobulin superfamily, Mol. Cell. Biol., 26, 718, 10.1128/MCB.26.2.718-726.2006 Gage, 1989, Age-related impairments in spatial memory are independent of those in sensorimotor skills, Neurobiol. Aging, 10, 347, 10.1016/0197-4580(89)90047-X Gerrow, 2006, Cell adhesion molecules at the synapse, Front. Biosci., 11, 2400, 10.2741/1978 Giagtzoglou, 2009, Cell adhesion, the backbone of the synapse: “Vertebrate” and “invertebrate” perspectives, Cold Spring Harb. Perspect. Biol., 1, a003079, 10.1101/cshperspect.a003079 Graf, 2004, Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins, Cell, 119, 1013, 10.1016/j.cell.2004.11.035 Gresack, 2004, Environmental enrichment reduces the mnemonic and neural benefits of estrogen, Neuroscience, 128, 459, 10.1016/j.neuroscience.2004.06.011 Hung, 2008, Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1, J. Neurosci., 28, 1697, 10.1523/JNEUROSCI.3032-07.2008 Irwin, 2001, Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: A quantitative examination, Am. J. Med. Genet., 98, 161, 10.1002/1096-8628(20010115)98:2<161::AID-AJMG1025>3.0.CO;2-B Jin, 2008, Molecular mechanisms of presynaptic differentiation, Annu. Rev. Cell Dev. Biol., 24, 237, 10.1146/annurev.cellbio.23.090506.123417 Jones, 1974, Isolation of synaptic plasma membrane from brain by combined flotation-sedimentation density gradient centrifugation, Biochim. Biophys. Acta, 356, 276, 10.1016/0005-2736(74)90268-5 Kayser, 2006, Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors, J. Neurosci., 26, 12152, 10.1523/JNEUROSCI.3072-06.2006 Kemp, 2004, Hippocampal long-term depression and long-term potentiation encode different aspects of novelty acquisition, Proc. Natl. Acad. Sci. USA, 101, 8192, 10.1073/pnas.0402650101 Kim, 2008, Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals, Proc. Natl. Acad. Sci. USA, 105, 9087, 10.1073/pnas.0803448105 Knott, 2006, Spine growth precedes synapse formation in the adult neocortex in vivo, Nat. Neurosci., 9, 1117, 10.1038/nn1747 Lee, 2009, The molecular and cellular biology of enhanced cognition, Nat. Rev. Neurosci., 10, 126, 10.1038/nrn2572 Li, 2004, Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice, Proc. Natl. Acad. Sci. USA, 101, 2185, 10.1073/pnas.0307313101 Lister, 1987, The use of a plus-maze to measure anxiety in the mouse, Psychopharmacology (Berl.), 92, 180, 10.1007/BF00177912 Lyckman, 2008, Gene expression patterns in visual cortex during the critical period: Synaptic stabilization and reversal by visual deprivation, Proc. Natl. Acad. Sci. USA, 105, 9409, 10.1073/pnas.0710172105 Mansuy, 2000, Tetracycline-regulated gene expression in the brain, Curr. Opin. Neurobiol., 10, 593, 10.1016/S0959-4388(00)00127-6 Mayford, 1996, Control of memory formation through regulated expression of a CaMKII transgene, Science, 274, 1678, 10.1126/science.274.5293.1678 Megias, 2001, Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells, Neuroscience, 102, 527, 10.1016/S0306-4522(00)00496-6 Nam, 2005, Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter, Proc. Natl. Acad. Sci. USA, 102, 6137, 10.1073/pnas.0502038102 Nelson, 2008, Strength through diversity, Neuron, 60, 477, 10.1016/j.neuron.2008.10.020 Neves, 2008, Synaptic plasticity, memory and the hippocampus: A neural network approach to causality, Nat. Rev. Neurosci., 9, 65, 10.1038/nrn2303 Nicholls, 2008, Transgenic mice lacking NMDAR-dependent LTD exhibit deficits in behavioral flexibility, Neuron, 58, 104, 10.1016/j.neuron.2008.01.039 Okamura, 2004, Cadherin activity is required for activity-induced spine remodeling, J. Cell Biol., 167, 961, 10.1083/jcb.200406030 Rabenstein, 2005, Impaired synaptic plasticity and learning in mice lacking beta-adducin, an actin-regulating protein, J. Neurosci., 25, 2138, 10.1523/JNEUROSCI.3530-04.2005 Raghavachari, 2004, Properties of quantal transmission at CA1 synapses, J. Neurophysiol., 92, 2456, 10.1152/jn.00258.2004 Rosahl, 1995, Essential functions of synapsins I and II in synaptic vesicle regulation, Nature, 375, 488, 10.1038/375488a0 Sara, 2005, Selective capability of SynCAM and neuroligin for functional synapse assembly, J. Neurosci., 25, 260, 10.1523/JNEUROSCI.3165-04.2005 Scheiffele, 2000, Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons, Cell, 101, 657, 10.1016/S0092-8674(00)80877-6 Stagi, 2010, SynCAM 1 participates in axo-dendritic contact assembly and shapes neuronal growth cones, Proc. Natl. Acad. Sci. USA, 107, 7568, 10.1073/pnas.0911798107 Südhof, 2008, Neuroligins and neurexins link synaptic function to cognitive disease, Nature, 455, 903, 10.1038/nature07456 Thomas, 2008, Expression and adhesion profiles of SynCAM molecules indicate distinct neuronal functions, J. Comp. Neurol., 510, 47, 10.1002/cne.21773 Togashi, 2002, Cadherin regulates dendritic spine morphogenesis, Neuron, 35, 77, 10.1016/S0896-6273(02)00748-1 Varoqueaux, 2006, Neuroligins determine synapse maturation and function, Neuron, 51, 741, 10.1016/j.neuron.2006.09.003 Verhage, 2000, Synaptic assembly of the brain in the absence of neurotransmitter secretion, Science, 287, 864, 10.1126/science.287.5454.864 Wang, 2009, Common genetic variants on 5p14.1 associate with autism spectrum disorders, Nature, 459, 528, 10.1038/nature07999 Wierenga, 2008, GABAergic synapses are formed without the involvement of dendritic protrusions, Nat. Neurosci., 11, 1044, 10.1038/nn.2180 Zelano, 2009, SynCAM1 expression correlates with restoration of central synapses on spinal motoneurons after two different models of peripheral nerve injury, J. Comp. Neurol., 517, 670, 10.1002/cne.22186 Zhiling, 2008, Mutations in the gene encoding CADM1 are associated with autism spectrum disorder, Biochem. Biophys. Res. Commun., 377, 926, 10.1016/j.bbrc.2008.10.107 Zhou, 2004, Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses, Neuron, 44, 749, 10.1016/j.neuron.2004.11.011 Ziv, 1996, Evidence for a role of dendritic filopodia in synaptogenesis and spine formation, Neuron, 17, 91, 10.1016/S0896-6273(00)80283-4 Zoghbi, 2003, Postnatal neurodevelopmental disorders: Meeting at the synapse?, Science, 302, 826, 10.1126/science.1089071