Role of HSD17B13 in the liver physiology and pathophysiology

Abul-Husn, 2018, A protein-truncating HSD17B13 variant and protection from chronic liver disease, N. Engl. J. Med., 378, 1096, 10.1056/NEJMoa1712191 Adam, 2018, Hydroxysteroid (17beta) dehydrogenase 13 deficiency triggers hepatic steatosis and inflammation in mice, Faseb. J., 32, 3434, 10.1096/fj.201700914R Adams, 2005, The natural history of nonalcoholic fatty liver disease: a population-based cohort study, Gastroenterology, 129, 113, 10.1053/j.gastro.2005.04.014 Cai, 2005, Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB, Nat. Med., 11, 183, 10.1038/nm1166 Carr, 2016, Pathophysiology of lipid droplet proteins in liver diseases, Exp. Cell Res., 340, 187, 10.1016/j.yexcr.2015.10.021 Carr, 2017, Perilipin staining distinguishes between steatosis and nonalcoholic steatohepatitis in adults and children, Clin. Gastroenterol. Hepatol., 15, 145, 10.1016/j.cgh.2016.08.023 Carr, 2012, Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice, Am. J. Physiol. Regul. Integr. Comp. Physiol., 302, R996, 10.1152/ajpregu.00177.2011 Carracedo, 2013, Cancer metabolism: fatty acid oxidation in the limelight, Nat. Rev. Canc., 13, 227, 10.1038/nrc3483 Chambers, 2011, Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma, Nat. Genet., 43, 1131, 10.1038/ng.970 Cohen, 2011, Human fatty liver disease: old questions and new insights, Science, 332, 1519, 10.1126/science.1204265 Cotoi, 2012, Whole-genome DASL gene expression profiling of hepatocellular carcinoma sub-populations isolated by laser microdissection on formalin-fixed and paraffin-embedded liver tissue samples, Rom. J. Morphol. Embryol., 53, 893 Crunk, 2013, Dynamic regulation of hepatic lipid droplet properties by diet, PLoS One, 8, 10.1371/journal.pone.0067631 Cusi, 2016, Long-term pioglitazone treatment for patients with nonalcoholic steatohepatitis and prediabetes or type 2 diabetes mellitus: a randomized trial, Ann. Intern. Med., 165, 305, 10.7326/M15-1774 de Azevedo, 2017, Genetic variants underlying vitamin D metabolism and VDR-TGFbeta-1-SMAD3 interaction may impact on HCV progression: a study based on dbGaP data from the HALT-C study, J. Hum. Genet., 62, 969, 10.1038/jhg.2017.75 El-Serag, 2007, Hepatocellular carcinoma: epidemiology and molecular carcinogenesis, Gastroenterology, 132, 2557, 10.1053/j.gastro.2007.04.061 Gross, 2017, PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD, Nat. Rev. Endocrinol., 13, 36, 10.1038/nrendo.2016.135 He, 2010, A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis, J. Biol. Chem., 285, 6706, 10.1074/jbc.M109.064501 Higuchi, 2008, Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease, Hepatol. Res., 38, 1122, 10.1111/j.1872-034X.2008.00382.x Horiguchi, 2008, 17beta-Hydroxysteroid dehydrogenase type 13 is a liver-specific lipid droplet-associated protein, Biochem. Biophys. Res. Commun., 370, 235, 10.1016/j.bbrc.2008.03.063 Jinno, 2010, Cide-a and Cide-c are induced in the progression of hepatic steatosis and inhibited by eicosapentaenoic acid, Prostaglandins Leukot. Essent. Fatty Acids, 83, 75, 10.1016/j.plefa.2010.05.002 Kampf, 2014, The human liver-specific proteome defined by transcriptomics and antibody-based profiling, Faseb. J., 28, 2901, 10.1096/fj.14-250555 Kase, 2005, Skeletal muscle lipid accumulation in type 2 diabetes may involve the liver X receptor pathway, Diabetes, 54, 1108, 10.2337/diabetes.54.4.1108 Kunutsor, 2013, Liver aminotransferases and risk of incident type 2 diabetes: a systematic review and meta-analysis, Am. J. Epidemiol., 178, 159, 10.1093/aje/kws469 Larsson, 2007, Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies, Br. J. Canc., 97, 1005, 10.1038/sj.bjc.6603932 Lee, 2017, Network analyses identify liver-specific targets for treating liver diseases, Mol. Syst. Biol., 13, 938, 10.15252/msb.20177703 Liu, 2007, Molecular cloning and expression analysis of a new gene for short-chain dehydrogenase/reductase 9, Acta Biochim. Pol., 54, 213, 10.18388/abp.2007_3289 Loomba, 2018, The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: a randomized, phase 2 trial, Hepatology, 67, 2063 Marchais-Oberwinkler, 2011, 17beta-Hydroxysteroid dehydrogenases (17beta-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development, J. Steroid Biochem. Mol. Biol., 125, 66, 10.1016/j.jsbmb.2010.12.013 Marrero, 2002, NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States, Hepatology, 36, 1349, 10.1002/hep.1840360609 McManaman, 2013, Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease, J. Lipid Res., 54, 1346, 10.1194/jlr.M035063 Michelotti, 2013, NAFLD, NASH and liver cancer, Nat. Rev. Gastroenterol. Hepatol., 10, 656, 10.1038/nrgastro.2013.183 Mitsumoto, 2017, Time-course microarrays reveal early activation of the immune transcriptome in a choline-deficient mouse model of liver injury, Life Sci., 184, 103, 10.1016/j.lfs.2017.07.009 Montagner, 2016, Liver PPARalpha is crucial for whole-body fatty acid homeostasis and is protective against NAFLD, Gut, 65, 1202, 10.1136/gutjnl-2015-310798 Mota, 2016, Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease, Metabolism, 65, 1049, 10.1016/j.metabol.2016.02.014 Motomura, 2006, Up-regulation of ADRP in fatty liver in human and liver steatosis in mice fed with high fat diet, Biochem. Biophys. Res. Commun., 340, 1111, 10.1016/j.bbrc.2005.12.121 Neuschwander-Tetri, 2003, Nonalcoholic steatohepatitis: summary of an AASLD single topic conference, Hepatology, 37, 1202, 10.1053/jhep.2003.50193 Neuschwander-Tetri, 2015, Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial, Lancet, 385, 956, 10.1016/S0140-6736(14)61933-4 Patterson, 2011, Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling, Cancer Res., 71, 6590, 10.1158/0008-5472.CAN-11-0885 Pratt, 2000, Evaluation of abnormal liver-enzyme results in asymptomatic patients, N. Engl. J. Med., 342, 1266, 10.1056/NEJM200004273421707 Ratziu, 2016, Elafibranor, an agonist of the peroxisome proliferator-activated receptor-alpha and -delta, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening, Gastroenterology, 150, 10.1053/j.gastro.2016.01.038 Rotinen, 2010, Type 10 17beta-hydroxysteroid dehydrogenase expression is regulated by C/EBPbeta in HepG2 cells, J. Steroid Biochem. Mol. Biol., 122, 164, 10.1016/j.jsbmb.2010.07.003 Rotroff, 2018, Genetic variants in HSD17B3, SMAD3, and IPO11 impact circulating lipids in response to fenofibrate in individuals with type 2 diabetes, Clin. Pharmacol. Ther., 103, 712, 10.1002/cpt.798 Saloniemi, 2012, The diversity of sex steroid action: novel functions of hydroxysteroid (17beta) dehydrogenases as revealed by genetically modified mouse models, J. Endocrinol., 212, 27, 10.1530/JOE-11-0315 Sanyal, 2010, Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis, N. Engl. J. Med., 362, 1675, 10.1056/NEJMoa0907929 Schultz, 2000, Role of LXRs in control of lipogenesis, Genes Dev., 14, 2831, 10.1101/gad.850400 Shaker, 2014, Liver transplantation for nonalcoholic fatty liver disease: new challenges and new opportunities, World J. Gastroenterol., 20, 5320, 10.3748/wjg.v20.i18.5320 Smagris, 2015, Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis, Hepatology, 61, 108, 10.1002/hep.27242 Soderberg, 2010, Decreased survival of subjects with elevated liver function tests during a 28-year follow-up, Hepatology, 51, 595, 10.1002/hep.23314 Song, 2015, Recent advances in surgical treatment of hepatocellular carcinoma, Drug Discov. Ther., 9, 319, 10.5582/ddt.2015.01051 Spichiger, 2015, Gestation under chronic constant light leads to extensive gene expression changes in the fetal rat liver, Physiol. Genom., 47, 621, 10.1152/physiolgenomics.00023.2015 Stickel, 2010, Non-alcoholic fatty liver disease as a risk factor for hepatocellular carcinoma: mechanisms and implications, Gut, 59, 1303, 10.1136/gut.2009.199661 Straub, 2008, Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis, Hepatology, 47, 1936, 10.1002/hep.22268 Stulnig, 2002, Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue, Mol. Pharmacol., 62, 1299, 10.1124/mol.62.6.1299 Su, 2017, Liver X receptor alpha induces 17beta-hydroxysteroid dehydrogenase-13 expression through SREBP-1c, Am. J. Physiol. Endocrinol. Metab., 312, E357, 10.1152/ajpendo.00310.2016 Su, 2014, Comparative proteomic study reveals 17beta-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease, Proc. Natl. Acad. Sci. U. S. A., 111, 11437, 10.1073/pnas.1410741111 Tsai, 2017, The constitutive lipid droplet protein PLIN2 regulates autophagy in liver, Autophagy, 13, 1130, 10.1080/15548627.2017.1319544 Vinciguerra, 2009, Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN, J. Hepatol., 50, 1132, 10.1016/j.jhep.2009.01.027 Vuorinen, 2014, Ligand-based pharmacophore modeling and virtual screening for the discovery of novel 17beta-hydroxysteroid dehydrogenase 2 inhibitors, J. Med. Chem., 57, 5995, 10.1021/jm5004914 Wang, 2015, Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis, Hepatology, 61, 870, 10.1002/hep.27409 Wang, 2015, Transcriptional regulation of hepatic lipogenesis, Nat. Rev. Mol. Cell Biol., 16, 678, 10.1038/nrm4074 White, 2012, Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review, Clin. Gastroenterol. Hepatol., 10, 10.1016/j.cgh.2012.10.001 Xing, 2015, Comparative analysis of primary hepatocellular carcinoma with single and multiple lesions by iTRAQ-based quantitative proteomics, J. Proteomics, 128, 262, 10.1016/j.jprot.2015.08.007 Xu, 2014, Small nucleolar RNA 113-1 suppresses tumorigenesis in hepatocellular carcinoma, Mol. Canc., 13, 216, 10.1186/1476-4598-13-216 Xu, 2017, Mendelian randomization estimates of alanine aminotransferase with cardiovascular disease: Guangzhou Biobank Cohort study, Hum. Mol. Genet., 26, 430 Xu, 2018, Lipid droplet proteins and metabolic diseases, Biochim. Biophys. Acta, 1864, 1968, 10.1016/j.bbadis.2017.07.019 Younossi, 2016, Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes, Hepatology, 64, 73, 10.1002/hep.28431 Yu, 2016, Systemic transcriptome analysis of hepatocellular carcinoma, Tumour Biol., 37, 13323, 10.1007/s13277-016-5286-5