New-generation Skulachev ions exhibiting nephroprotective and neuroprotective properties

Biochemistry (Moscow) - Tập 75 - Trang 145-150 - 2010
E. Y. Plotnikov1,2, D. N. Silachev1,2, A. A. Chupyrkina1,2, M. I. Danshina2, S. S. Jankauskas2, M. A. Morosanova2,3, E. V. Stelmashook2,4, A. K. Vasileva1,2, E. S. Goryacheva2,3, Y. A. Pirogov5, N. K. Isaev1,2,4, D. B. Zorov2
1Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia
2Mitoengineering Research Institute, Lomonosov Moscow State University, Moscow, Russia
3Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia
4Department of Brain Research, Neurology Research Center, Russian Academy of Medical Sciences, Moscow, Russia
5Training and Research Interfaculty Center of Magnetic Tomography and Spectroscopy, Lomonosov Moscow State University, Moscow, Russia

Tóm tắt

A mitochondria-targeted chimeric compound consisting of a rhodamine derivative linked to a plastoquinone molecule (10-(6′-plastoquinonyl)decylrhodamine, SkQR1) was studied under conditions of acute brain or kidney damage. A protective effect of this compound was demonstrated in a model of focal brain ischemia, rat kidney ischemia/reperfusion, myoglobinuria (rhabdomyolysis, or crush syndrome), and pyelonephritis. We found that a single intraperitoneal injection of SkQR1 diminishes the size of the ischemic zone in the brain and improves performance of a test characterizing neurological deficit in ischemic animals. An analog of SkQR1 not containing plastoquinone (C12R19) was not neuroprotective. The data show that SkQR1 is a nephroprotectant and neuroprotectant, which can be due to the antioxidative action of this Skulachev cation.

Tài liệu tham khảo

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