Immunostimulatory CpG-oligodeoxynucleotides (CpG-ODN) induce early hepatic injury, but provide a late window for protection against endotoxin-mediated liver damage

Journal of Hepatology - Tập 44 - Trang 576-585 - 2006
Jan E. Slotta1, Claudia Scheuer1, Michael D. Menger1, Brigitte Vollmar2
1Institute for Clinical and Experimental Surgery, University of Saarland, 66421 Homburg/Saar, Germany
2Department of Experimental Surgery, University of Rostock, Schillingalle 70, 18055 Rostock, Germany

Tài liệu tham khảo

Kox, 2000, Immunomodulatory therapies in sepsis, Intensive Care Med, 26, S124, 10.1007/s001340051129 Ziegler, 1991, Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group, N Engl J Med, 324, 429, 10.1056/NEJM199102143240701 Abraham, 1998, Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group, Lancet, 351, 929, 10.1016/S0140-6736(00)80009-4 Randow, 1995, Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor beta, J Exp Med, 181, 1887, 10.1084/jem.181.5.1887 Goebel, 2000, Injury induces deficient interleukin-12 production, but interleukin-12 therapy after injury restores resistance to infection, Ann Surg, 231, 253, 10.1097/00000658-200002000-00015 O'Reilly, 1992, Interleukin 1 beta improves survival following cecal ligation and puncture, J Surg Res, 52, 518, 10.1016/0022-4804(92)90321-P Echtenacher, 1996, Critical protective role of mast cells in a model of acute septic peritonitis, Nature, 381, 75, 10.1038/381075a0 Krieg, 2000, Immune effects and mechanisms of action of CpG motifs, Vaccine, 19, 618, 10.1016/S0264-410X(00)00249-8 Krieg, 1995, CpG motifs in bacterial DNA trigger direct B-cell activation, Nature, 374, 546, 10.1038/374546a0 Klinman, 1996, CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma, Proc Natl Acad Sci USA, 93, 2879, 10.1073/pnas.93.7.2879 Juffermans, 2002, CpG oligodeoxynucleotides enhance host defense during murine tuberculosis, Infect Immun, 70, 147, 10.1128/IAI.70.1.147-152.2002 Krieg, 1998, CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge, J Immunol, 161, 2428, 10.4049/jimmunol.161.5.2428 Zimmermann, 1998, CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis, J Immunol, 160, 3627, 10.4049/jimmunol.160.8.3627 Oxenius, 1999, CpG-containing oligonucleotides are efficient adjuvants for induction of protective antiviral immune responses with T-cell peptide vaccines, J Virol, 73, 4120, 10.1128/JVI.73.5.4120-4126.1999 Weighardt, 2000, Increased resistance against acute polymicrobial sepsis in mice challenged with immuno-stimulatory CpG oligodeoxynucleotides is related to an enhanced innate effector cell response, J Immunol, 165, 4537, 10.4049/jimmunol.165.8.4537 Cowdery, 1996, Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides, J Immunol, 156, 4570, 10.4049/jimmunol.156.12.4570 Vollmar, 1997, High-resolution microscopic determination of hepatic NADH fluorescence for in vivo monitoring of tissue oxygenation during hemorrhagic shock and resuscitation, Microvasc Res, 54, 164, 10.1006/mvre.1997.2028 Vollmar, 1994, Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion, Am J Pathol, 145, 1421 Schäfer, 2003, Inhibition of p53 protects liver tissue against endotoxin-induced apoptotic and necrotic cell death, Fed Am Soc Exp Brol J., 17, 660 Vollmar, 1994, Impact of leukocyte-endothelial interaction in hepatic ischemia-reperfusion injury, Am J Physiol, 267, G786 Vollmar, 1996, Modulation of Kupffer cell activity by gadolinium chloride in endotoxemic rats, Shock, 6, 434, 10.1097/00024382-199612000-00008 Menger, 2000, Role of microcirculation in transplantation, Microcirculation, 7, 291, 10.1038/sj.mn.7300117 Eipel, 2004, Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia, Am J Physiol Gastrointest Liver Physiol, 286, G769, 10.1152/ajpgi.00275.2003 Lowry, 1951, Protein measurement with the Folin phenol reagent, J Biol Chem, 193, 265, 10.1016/S0021-9258(19)52451-6 Chu, 1997, CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity, J Exp Med, 186, 1623, 10.1084/jem.186.10.1623 Gao, 2001, and lipopolysaccharide induce synergistic production of TNF-alpha through a post-transcriptional mechanism, J Immunol, 166, 6855, 10.4049/jimmunol.166.11.6855 Yi, 2001, Lipopolysaccharide and CpG DNA synergize for tumor necrosis factor-alpha production through activation of NF-kappaB, Int Immunol, 13, 1391, 10.1093/intimm/13.11.1391 Schuchmann, 2004, HSP60 and CpG-DNA-oligonucleotides differentially regulate LPS-tolerance of hepatic Kupffer cells, Immunol Lett, 93, 199, 10.1016/j.imlet.2004.03.016 Cornelie, 2002, Cytosine-phosphate-guanine (CpG) motifs are sensitizing agents for lipopolysaccharide in toxic shock model, Intensive Care Med, 28, 1340, 10.1007/s00134-002-1418-z Jin, 2002, Preexposure of murine macrophages to CpG-containing oligonucleotides results in nuclear factor kappaB p50 homodimer-associated hyporesponsiveness, Surgery, 132, 245, 10.1067/msy.2002.125355 Yeo, 2003, induces self and cross-hyporesponsiveness of RAW264.7 cells in response to CpG DNA and lipopolysaccharide: alterations in IL-1 receptor-associated kinase expression, J Immunol, 170, 1052, 10.4049/jimmunol.170.2.1052 Smith, 2004, Impact of immunomodulatory oligodeoxynucleotides on cytokine production in the lipopolysaccharide-stimulated human whole blood model, Surgery, 136, 464, 10.1016/j.surg.2004.05.026 Schwartz, 1999, or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway, J Immunol, 163, 224, 10.4049/jimmunol.163.1.224 Crabtree, 2001, Preexposure of murine macrophages to CpG oligonucleotide results in a biphasic tumor necrosis factor alpha response to subsequent lipopolysaccharide challenge, Infect Immun, 69, 2123, 10.1128/IAI.69.4.2123-2129.2001 Flohe, 1999, Endotoxin tolerance in rats: expression of TNF-alpha, IL-6, IL-10, VCAM-1 and HSP 70 in lung and liver during endotoxin shock, Cytokine, 11, 796, 10.1006/cyto.1998.0490 Essani, 1995, Cytokine-induced upregulation of hepatic intercellular adhesion molecule-1 messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure, Hepatology, 21, 1632 Echtenacher, 2001, Differences in innate defense mechanisms in endotoxemia and polymicrobial septic peritonitis, Infect Immun, 69, 7271, 10.1128/IAI.69.12.7172-7276.2001 Vollmar, 1993, Role of leukocytes in the initial hepatic microvascular response to endotoxemia, Zentralbl Chir, 118, 691 Ceydeli, 2003, The septic abscess wall: a cytokine-generating organ associated with portal venous cytokinemia, hepatic outflow fibrosis, sinusoidal congestion, inflammatory cell sequestration, hepatocellular lipid deposition, and focal cell death, Shock, 20, 74, 10.1097/01.shk.0000065769.72937.2b Isaka, 2000, Ultrastructural changes of the vascular endothelium after intra-arterial administration of tumor necrosis factor-alpha (TNFalpha) in rat gliomas, J Neurooncol, 46, 145, 10.1023/A:1006477217342 Hohlfeld, 1995, The contribution of tumour necrosis factor-alpha and endothelin-1 to the increase of coronary resistance in hearts from rats treated with endotoxin, Br J Pharmacol, 116, 3309, 10.1111/j.1476-5381.1995.tb15140.x Eakes, 1998, Regulation of endothelin synthesis in hepatic endothelial cells, Am J Physiol, 274, G1068 Utaisincharoen, 2002, CpG ODN activates NO and iNOS production in mouse macrophage cell line (RAW 264.7), Clin Exp Immunol, 128, 467, 10.1046/j.1365-2249.2002.01866.x Chow, 1999, Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction, J Biol Chem, 274, 10689, 10.1074/jbc.274.16.10689 Hoshino, 1999, Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product, J Immunol, 162, 3749, 10.4049/jimmunol.162.7.3749 Lien, 2000, Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide, J Clin Invest, 105, 497, 10.1172/JCI8541 Muzio, 2001, Toll-like receptors (TLRs) signalling and expression pattern, J Endotoxin Res, 7, 297, 10.1179/096805101101532882 Migita, 2004, Lipopolysaccharide signaling induces serum amyloid A (SAA) synthesis in human hepatocytes in vitro, Fed Eur Biochem Soc Lett, 569, 235, 10.1016/j.febslet.2004.05.072 Liu, 2002, Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide, Infect Immun, 70, 3433, 10.1128/IAI.70.7.3433-3442.2002 Paik, 2003, Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells, Hepatology, 37, 1043, 10.1053/jhep.2003.50182 Halpern, 1996, induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha, Cell Immunol, 167, 72, 10.1006/cimm.1996.0009 Yamamoto, 1992, DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth, Microbiol Immunol, 36, 983, 10.1111/j.1348-0421.1992.tb02102.x Akira, 2001, Toll-like receptors: critical proteins linking innate and acquired immunity, Nat Immunol, 2, 675, 10.1038/90609 Calvano, 2003, Modulation of the lipopolysaccharide receptor complex (CD14, TLR4, MD-2) and toll-like receptor 2 in systemic inflammatory response syndrome-positive patients with and without infection: relationship to tolerance, Shock, 20, 415, 10.1097/01.shk.0000092269.01859.44 Aderem, 2000, Toll-like receptors in the induction of the innate immune response, Nature, 406, 782, 10.1038/35021228 Hirschfeld, 2001, Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages, Infect Immun, 69, 1477, 10.1128/IAI.69.3.1477-1482.2001 Lomaga, 1999, TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling, Genes Dev, 13, 1015, 10.1101/gad.13.8.1015 Sparwasser, 1997, Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock, Eur J Immunol, 27, 1671, 10.1002/eji.1830270712 Lipford, 1997, Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines, Eur J Immunol, 27, 3420, 10.1002/eji.1830271242 Sparwasser, 1997, Bacterial DNA causes septic shock, Nature, 386, 336, 10.1038/386336a0 Kreutz, 1997, A comparative analysis of cytokine production and tolerance induction by bacterial lipopeptides, lipopolysaccharides and Staphyloccous aureus in human monocytes, Immunology, 92, 396, 10.1046/j.1365-2567.1997.00365.x Sato, 2000, Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways, J Immunol, 165, 7096, 10.4049/jimmunol.165.12.7096