Expression of cyclooxygenase‐1 and cyclooxygenase‐2 in bronchial epithelium and nonsmall cell lung carcinoma

Cancer - Tập 94 Số 4 - Trang 1023-1031 - 2002
Serap Hastürk1, Bonnie L. Kemp2, Shyla K. Kalapurakal1, Jonathan M. Kurie1, Waun Ki Hong1, Jin S. Lee1
1Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
2Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas

Tóm tắt

AbstractBACKGROUNDCyclooxygenase (Cox) is the main target enzyme for the nonsteroidal antiinflammatory drugs that have been shown to suppress carcinogenesis in both experimental models and epidemiologic studies.METHODSTo evaluate its utility as an intermediate biomarker in bronchial chemoprevention trials, the authors examined Cox 1 and Cox 2 expression in normal and premalignant bronchial epithelial cells and nonsmall cell lung carcinoma (NSCLC) samples using an immunohistochemical staining technique. Included in the current study were 101 NSCLC samples and 77 bronchial biopsy samples obtained from 15 healthy smokers.RESULTSIn the normal bronchial epithelium, Cox 2 expression was found to be completely negative whereas Cox 1 expression was noted in a few scattered cells. The areas of basal cell hyperplasia and squamous metaplasia demonstrated the same pattern. There were relatively more Cox 2‐positive tumors, as defined by positive staining in > 10% of tumor cells, than Cox 1‐positive tumors (30 of 101 tumors [30%] vs. 14 of 101 tumors [14%]; P = 0.01). When tumor types were considered, there were more Cox 2‐positive adenocarcinomas compared with squamous cell carcinomas (21 of 51 adenocarcinomas [41%] vs. 9 of 46 squamous cell carcinomas [20%]; P = 0.03). In contrast, fewer adenocarcinomas tended to show Cox 1 expression compared with squamous cell carcinomas (4 of 51 adenocarcinomas [8%] vs. 9 of 46 squamous cell carcinomas [20%]; P = 0.14). Although smokers tended to have more Cox 2‐positive tumors than nonsmokers (29 of 91 tumors in the smokers [32%] vs. 1 of 10 tumors in the nonsmokers [10%]; P = 0.15), there was no statistically significant relation found between Cox 1 or Cox 2 expression and smoking status or prognostically significant clinicopathologic features.CONCLUSIONSThe results of the current study suggest that Cox 1 and Cox 2 expression may not be a useful intermediate biomarker in bronchial chemoprevention trials. Nevertheless, considering the patterns of Cox 1 and Cox 2 expression in tumor cells, Cox expression status may be a useful parameter when designing treatment strategies for a subset of NSCLC patients. Cancer 2002;94:1023–31. © 2002 American Cancer Society.DOI 10.1002/cncr.10262

Từ khóa


Tài liệu tham khảo

10.3322/canjclin.48.1.6

Garfinkel L, 1998, Smoking and lung cancer in women: findings in a prospective study, Cancer Res, 48, 6951

10.1002/(SICI)1097-0142(19960901)78:5<1004::AID-CNCR10>3.0.CO;2-6

10.1056/NEJM199404143301501

10.1056/NEJM199605023341802

Lee JS, 1992, Determination of biomarkers for intermediate end points in chemoprevention trials, Cancer Res, 52, 2707s

10.3181/00379727-216-44170

10.1096/fasebj.12.12.1063

10.1016/0092-8674(95)90127-2

10.1016/0959-8049(95)00137-8

10.1056/NEJM199509073331001

10.1007/BF02358623

10.1002/jcb.240560905

10.1016/S0952-3278(96)90064-2

10.1093/carcin/18.5.1001

10.1093/carcin/18.3.491

10.1097/00001648-199403000-00003

10.1016/0005-2760(91)90119-3

10.1007/BF00666095

Kargman SL, 1995, Expression of prostaglandin G/H synthase ‐1 and ‐2 in human colon cancer, Cancer Res, 55, 2556

Hida T, 1998, Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas, Cancer Res, 58, 3761

Wolff H, 1998, Expression of cyclooxygenase ‐2 in human lung carcinoma, Cancer Res, 58, 4997

World Health Organization, 1981, World Health Organization histological typing of lung tumors, 1

10.1378/chest.111.6.1710

10.1200/JCO.1994.12.5.937

10.1002/1097-0142(197401)33:1<256::AID-CNCR2820330139>3.0.CO;2-G

10.1034/j.1399-3003.1999.13e12.x

10.1203/00006450-200005000-00008

El‐Bayoumy K, 1999, Increased expression of cyclooxygenase‐2 in rat lung tumors induced by the tobacco‐specific nitrosamine 4‐(methylnitrosamino)‐4‐(3‐pyridyl)‐1‐butanone: the impact of a high‐fat diet, Cancer Res, 59, 1400

10.1165/ajrcmb.18.4.2939

Achiwa H, 1999, Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinoma, Clin Cancer Res, 5, 1001

10.1007/s000110050555

10.1093/carcin/18.4.795

Jims JJ, 1999, Reversal of the transcriptional rates of cyclooxygenase I and II genes in human fibroblasts and prostate cancer cells, Proc Am Assoc Cancer Res, 40, 2424

10.1093/carcin/21.1.15

10.1093/carcin/21.9.1745

10.1080/15287399409531825

Thông tin
Thông tin xuất bản

Cancer

Tập 94 Số 4

1023-1031

Thông tin tác giả