Tranexamic acid in traumatic brain injury: systematic review and meta-analysis trumps a large clinical trial?

Al Lawati K (2020) Efficacy and safety of Tranexamic acid in Acute traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials. Intensive Care Med. https://doi.org/10.1007/s00134-020-06279-w CRASH-3 trial collaborators (2019) Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. Lancet 394:1713–1723. https://doi.org/10.1016/S0140-6736(19)32233-0 Taccone FS, Citerio G, Stocchetti N (2019) Is tranexamic acid going to CRASH the management of traumatic brain injury? Intensive Care Med. https://doi.org/10.1007/s00134-019-05879-5 Rowell SE, Meier EN, McKnight B et al (2020) Effect of out-of-hospital tranexamic acid vs placebo on 6-month functional neurologic outcomes in patients with moderate or severe traumatic brain injury. JAMA 324:961–974. https://doi.org/10.1001/jama.2020.8958 Murad MH, Asi N, Alsawas M, Alahdab F (2016) New evidence pyramid. Evid-Based Med 21:125–127. https://doi.org/10.1136/ebmed-2016-110401 Yokobori S, Yatabe T, Kondo Y et al (2020) Efficacy and safety of tranexamic acid administration in traumatic brain injury patients: a systematic review and meta-analysis. J Intensive Care 8:46–49. https://doi.org/10.1186/s40560-020-00460-5