Biogeographic range expansion into South America byCoccidioides immitismirrors New World patterns of human migration

Proceedings of the National Academy of Sciences of the United States of America - Tập 98 Số 8 - Trang 4558-4562 - 2001
Matthew C. Fisher1, Gina L. Koenig1, Thomas J. White1, Gioconda San-Blas1, Ricardo Negroni1, Isidro Gutiérrez Alvarez1, Bodo Wanke1, John W. Taylor1
1Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720; Roche Molecular Systems, 1145 Atlantic Avenue, Alameda, CA 94501; Venezuelan Institute for Scientific Research, Center of Microbiology and Cell Biology, P.O. Box 21827, Caracas 1020A, Venezuela; Facultad de Medicina, Centro de Micologia, Departmento de Microbiologia, Buenos Aires, Argentina; Health Sciences Department, Universidad de Valle de México, C.P. 76100, Querétaro, Mexico; Laboratório de...

Tóm tắt

Long-distance population dispersal leaves its characteristic signature in genomes, namely, reduced diversity and increased linkage between genetic markers. This signature enables historical patterns of range expansion to be traced. Herein, we use microsatellite loci from the human pathogenCoccidioides immitisto show that genetic diversity in this fungus is geographically partitioned throughout North America. In contrast, analyses of South AmericanC. immitisshow that this population is genetically depauperate and was founded from a single North American population centered in Texas. Variances of allele distributions show that South AmericanC. immitishave undergone rapid population growth, consistent with an epidemic increase in postcolonization population size. Herein, we estimate the introduction into South America to have occurred within the last 9,000–140,000 years. This range increase parallels that ofHomo sapiens. Because of known associations between Amerindians and this fungus, we suggest that the colonization of South America byC. immitisrepresents a relatively recent and rapid codispersal of a host and its pathogen.

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Proceedings of the National Academy of Sciences of the United States of America

Tập 98 Số 8

4558-4562

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