Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption

Cell - Tập 127 Số 5 - Trang 917-928 - 2006
Andong Qiu1,2, Michaela Jansen3, Antoinette Sakaris4, Sang Hee Min1, Shrikanta Chattopadhyay1, Eugenia Tsai1,2, Claudio Sandoval5, Rongbao Zhao1,2, Myles H. Akabas1,3, I. David Goldman1,2
1Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
2Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461 USA
3Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
4Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
5Department of Pediatrics, New York Medical College, Valhalla, NY 10595 USA

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Anderson, 1992, Potocytosis: Sequestration and transport of small molecules by caveolae, Science, 255, 410, 10.1126/science.1310359

Benz, 1983, The molecular mechanism of action of the proton ionophore FCCP (carbonylcyanide p-trifluoromethoxyphenylhydrazone), Biophys. J., 41, 381, 10.1016/S0006-3495(83)84449-X

Boll, 2002, Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters, J. Biol. Chem., 277, 22966, 10.1074/jbc.M200374200

Eichholzer, 2006, Folic acid: A public-health challenge, Lancet, 367, 1352, 10.1016/S0140-6736(06)68582-6

Geller, 2002, Hereditary folate malabsorption: Family report and review of the literature, Medicine (Baltimore), 81, 51, 10.1097/00005792-200201000-00004

Hagenbuch, 2003, The superfamily of organic anion transporting polypeptides, Biochim. Biophys. Acta, 1609, 1, 10.1016/S0005-2736(02)00633-8

Helmlinger, 1997, Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation, Nat. Med., 3, 177, 10.1038/nm0297-177

Hidalgo, 1989, Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability, Gastroenterology, 96, 736, 10.1016/S0016-5085(89)80072-1

Horne, 1993, Transport of folates and antifolates in liver, Proc. Soc. Exp. Biol. Med., 202, 385, 10.3181/00379727-202-43550A

Jansen, 2006, State-dependent cross-linking of the M2 and M3 segments: Functional basis for the alignment of GABAA and acetylcholine receptor M3 segments, J. Neurosci., 26, 4492, 10.1523/JNEUROSCI.0224-06.2006

Koepsell, 2004, The SLC22 drug transporter family, Pflugers Arch., 447, 666, 10.1007/s00424-003-1089-9

Mason, 1994, Intestinal absorption of folate, 1979

Mason, 1990, Carrier affinity as a mechanism for the pH-dependence of folate transport in the small intestine, Biochim. Biophys. Acta, 1024, 331, 10.1016/0005-2736(90)90362-R

Matherly, 2003, Membrane transport of folates, Vitam. Horm., 66, 403, 10.1016/S0083-6729(03)01012-4

McEwan, 1990, A combined TDDA-PVC pH and reference electrode for use in the upper small intestine, J. Med. Eng. Technol., 14, 16, 10.3109/03091909009028758

Murphy, 1984, Endosome pH measured in single cells by dual fluorescence flow cytometry: Rapid acidification of insulin to pH 6, J. Cell Biol., 98, 1757, 10.1083/jcb.98.5.1757

Opladen, 2006, Analysis of 5-methyltetrahydrofolate in serum of healthy children, Mol. Genet. Metab., 87, 61, 10.1016/j.ymgme.2005.08.011

Paulos, 2004, Ligand binding and kinetics of folate receptor recycling in vivo: Impact on receptor-mediated drug delivery, Mol. Pharmacol., 66, 1406, 10.1124/mol.104.003723

Sagne, 2001, Identification and characterization of a lysosomal transporter for small neutral amino acids, Proc. Natl. Acad. Sci. USA, 98, 7206, 10.1073/pnas.121183498

Said, 2004, Recent advances in carrier-mediated intestinal absorption of water-soluble vitamins, Annu. Rev. Physiol., 66, 419, 10.1146/annurev.physiol.66.032102.144611

Selhub, 1981, Folate transport in isolated brush border membrane vesicles from rat intestine, J. Biol. Chem., 256, 4489, 10.1016/S0021-9258(19)69461-5

Sharif, 2000, Rapid determination of membrane transport parameters in adherent cells, Biotechniques, 28, 926, 10.2144/00285st06

Shayeghi, 2005, Identification of an intestinal heme transporter, Cell, 122, 789, 10.1016/j.cell.2005.06.025

Stover, 2004, Physiology of folate and vitamin B12 in health and disease, Nutr. Rev., 62, S3, 10.1111/j.1753-4887.2004.tb00070.x

Wang, 2004, Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier, Clin. Cancer Res., 10, 6256, 10.1158/1078-0432.CCR-04-0645

Wang, 2005, Preservation of folate transport activity with a low-pH optimum in rat IEC-6 intestinal epithelial cell lines that lack reduced folate carrier function, Am. J. Physiol. Cell Physiol., 288, C65, 10.1152/ajpcell.00307.2004

Wike-Hooley, 1984, The relevance of tumour pH to the treatment of malignant disease, Radiother. Oncol., 2, 343, 10.1016/S0167-8140(84)80077-8

Zhao, 2004, A prominent low-pH methotrexate transport activity in human solid tumor cells: Contribution to the preservation of methotrexate pharmacological activity in HeLa cells lacking the reduced folate carrier, Clin. Cancer Res., 10, 718, 10.1158/1078-0432.CCR-1066-03

Zhao, 2005, Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier, Clin. Cancer Res., 10, 8735, 10.1158/1078-0432.CCR-04-0932

Zhao, 2005, The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells, Biochim. Biophys. Acta, 1715, 57, 10.1016/j.bbamem.2005.07.003