Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock

Springer Science and Business Media LLC - Tập 15 - Trang 266-273 - 1995
A. Marchant1, M. L. Alegre2, A. Hakim1, G. Piérard1, G. Marécaux2, G. Friedman2, D. De Groote3, R. J. Kahn2, J. L. Vincent2, M. Goldman1
1Department of Immunology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
2Department of Intensive Care, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
3Medgenix Research Group and Development, Fleurus, Belgium

Tóm tắt

Interleukin-10 is a potent macrophage-deactivating cytokine that inhibits lipopolysaccharide-induced tumor necrosis factor production. We determined the plasma levels of immunoreactive interleukin-10 in 16 patients with septic shock and in 11 patients with circulatory shock of nonseptic origin. In septic shock, interleukin-10 levels peaked during the first 24 h (median: 48 pg/ml) and decreased progressively till Day 5. In nonseptic shock, interleukin-10 plasma levels also increased during the first 24 h but to a lesser extent (median: 17 pg/ml). In septic shock patients, interleukin-10 plasma levels were positively correlated with tumor necrosis factor (r=0.8,p=0.01) and with parameters of shock severity including lactate levels (r=0.56, p<0.05) and correlated negatively with blood platelet counts (r=−0.65,p<0.05). The decreased production of tumor necrosis factor-α and interleukin-6 afterin vitro incubation of whole blood from septic shock patients with lipopolysaccharide was not influenced byin vitro neutralization of interleukin-10. We conclude that interleukin-10 is produced in patients with circulatory shock of septic and nonseptic origin and that the production of this anti-inflammatory cytokine during septic shock correlates positively with the intensity of the inflammatory response.

Tài liệu tham khảo

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