Identification and Analysis of the Core Biosynthetic Machinery of Tubulysin, a Potent Cytotoxin with Potential Anticancer Activity
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Newman, 2003, Natural products as sources of new drugs over the period 1981–2002, J. Nat. Prod., 66, 1022, 10.1021/np030096l
Nicolaou, 1998, Chemical biology of epothilones, Angew. Chem. Int. Ed. Engl., 37, 2014, 10.1002/(SICI)1521-3773(19980817)37:15<2014::AID-ANIE2014>3.0.CO;2-2
Donadio, 2002, Microbial technologies for the discovery of novel bioactive metabolites, J. Biotechnol., 99, 187, 10.1016/S0168-1656(02)00209-2
Staunton, 2001, Polyketide biosynthesis, Nat. Prod. Rep., 18, 380, 10.1039/a909079g
Walsh, 2002, Combinatorial biosynthesis of antibiotics, Chembiochem, 3, 125, 10.1002/1439-7633(20020301)3:2/3<124::AID-CBIC124>3.0.CO;2-J
Cane, 1999, The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases, Chem. Biol., 6, R319, 10.1016/S1074-5521(00)80001-0
Gerth, 2003, Myxobacteria, J. Biotechnol., 106, 233, 10.1016/j.jbiotec.2003.07.015
Reichenbach, 1999, Myxobacteria as producers of secondary metabolites, 149
Gaitatzis, 2001, In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15, Proc. Natl. Acad. Sci. USA, 98, 11136, 10.1073/pnas.201167098
Gaitatzis, 2002, The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase, J. Biol. Chem., 277, 13082, 10.1074/jbc.M111738200
Silakowski, 1999, New lessons for combinatorial biosynthesis from Myxobacteria, J. Biol. Chem., 274, 37391, 10.1074/jbc.274.52.37391
Weinig, 2003, Melithiazol biosynthesis, Chem. Biol., 10, 939, 10.1016/j.chembiol.2003.09.012
Kunze, 1995, Chondramides A–D, new antifungal and cytostatic depsipeptides from Chondromyces crocatus (myxobacteria). Production, physico-chemical and biological properties, J. Antibiot. (Tokyo), 48, 1262, 10.7164/antibiotics.48.1262
Sasse, 1998, The chondramides, J. Natl. Cancer Inst., 90, 1559, 10.1093/jnci/90.20.1559
Sasse, 1993, Rhizopodin, a new compound from Myxococcus stipitatus (myxobacteria) causes formation of rhizopodia-like structures in animal cell cultures. Production, isolation, physico-chemical and biological properties, J. Antibiot. (Tokyo), 46, 741, 10.7164/antibiotics.46.741
Gerth, 1996, Epothilons A and B, J. Antibiot. (Tokyo), 49, 560, 10.7164/antibiotics.49.560
Bollag, 1995, Epothilones, a new class of microtubule-stabilizing agents with Taxol-like mechanism of action, Cancer Res., 55, 2325
Elnakady, 2004, Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells, Biochem. Pharmacol., 49, 560
Sasse, 2000, Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli—production, isolation, physico-chemical and biological properties, J. Antibiot. (Tokyo)., 53, 879, 10.7164/antibiotics.53.879
Steinmetz, 2004, Isolation, crystal and solution structure, and biosynthesis of tubulysins—powerful inhibitors of tubulin polymerisation from myxobacteria, Angew. Chem. Int. Ed. Engl., in press
Molnar, 2000, The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90, Chem. Biol., 7, 97, 10.1016/S1074-5521(00)00075-2
Tang, 2000, Cloning and heterologous expression of the epothilone gene cluster, Science, 287, 640, 10.1126/science.287.5453.640
Arslanian, 2002, A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus, J. Nat. Prod., 65, 1061, 10.1021/np020120f
Neumann, 1992, Rapid isolation of genomic DNA from Gram negative bacteria, Trends Genet., 8, 332, 10.1016/0168-9525(92)90146-U
1989
Thompson, 1994, Clustal w, Nucleic Acids Res., 22, 4673, 10.1093/nar/22.22.4673
Rubin, 1999, In vivo transposition of mariner-based elements in enteric bacteria and mycobacteria, Proc. Natl. Acad. Sci. USA, 96, 1645, 10.1073/pnas.96.4.1645
Sandmann, 2002, Search for genes involved in the production of bioactive secondary metabolites in the myxobacterium Angiococcus disciformis An d48 using a mariner based transposon mutagenesis, 66
Silakowski, 2001, Multiple hybrid polyketide synthase/non-ribosomal peptide synthetase gene clusters in the myxobacterium Stigmatella aurantiaca, Gene, 275, 233, 10.1016/S0378-1119(01)00680-1
Donadio, 1991, Modular organization of genes required for complex polyketide biosynthesis, Science, 252, 675, 10.1126/science.2024119
Schwecke, 1995, The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin, Proc. Natl. Acad. Sci. USA, 92, 7839, 10.1073/pnas.92.17.7839
Kleinkauf, 1997, Products of secondary metabolism, 277
Konz, 1999, How do peptide synthetases generate structural diversity?, Chem. Biol., 6, R39, 10.1016/S1074-5521(99)80002-7
Shimkets, 1993, The myxobacterial genome, 85
Challis, 2000, Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains, Chem. Biol., 7, 211, 10.1016/S1074-5521(00)00091-0
Stachelhaus, 1999, The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases, Chem. Biol., 6, 493, 10.1016/S1074-5521(99)80082-9
Kagan, 1994, Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggest a common structure for these enzymes, Arch. Biochem. Biophys., 310, 417, 10.1006/abbi.1994.1187
Khaw, 1998, Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase, J. Bacteriol., 180, 809, 10.1128/JB.180.4.809-814.1998
Tillett, 2000, Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806, Chem. Biol., 7, 753, 10.1016/S1074-5521(00)00021-1
Chen, 2001, Epothilone biosynthesis, Chem. Biol., 8, 899, 10.1016/S1074-5521(01)00064-3
Konz, 1999, Molecular and biochemical characterization of the protein template controlling biosynthesis of the lipopeptide lichenysin, J. Bacteriol., 181, 133, 10.1128/JB.181.1.133-140.1999
De Crecy-Lagard, 1995, Multienzyme nonribosomal peptide biosythesis, C. R. Acad. Sci. III, 318, 927
Conti, 1997, Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S, EMBO J., 16, 4174, 10.1093/emboj/16.14.4174