Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice

Avilion, 2003, Multipotent cell lineages in early mouse development depend on SOX2 function, Genes Dev., 17, 126, 10.1101/gad.224503 Barker, 2007, Identification of stem cells in small intestine and colon by marker gene Lgr5, Nature, 449, 1003, 10.1038/nature06196 Barker, 2010, Tissue-resident adult stem cell populations of rapidly self-renewing organs, Cell Stem Cell, 7, 656, 10.1016/j.stem.2010.11.016 Barker, 2010, Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro, Cell Stem Cell, 6, 25, 10.1016/j.stem.2009.11.013 Bass, 2009, SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas, Nat. Genet., 41, 1238, 10.1038/ng.465 Bjerknes, 2002, Multipotential stem cells in adult mouse gastric epithelium, Am. J. Physiol. Gastrointest. Liver Physiol., 283, G767, 10.1152/ajpgi.00415.2001 Brazel, 2005, Sox2 expression defines a heterogeneous population of neurosphere-forming cells in the adult murine brain, Aging Cell, 4, 197, 10.1111/j.1474-9726.2005.00158.x Breault, 2008, Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells, Proc. Natl. Acad. Sci. USA, 105, 10420, 10.1073/pnas.0804800105 Brinster, 1994, Spermatogenesis following male germ-cell transplantation, Proc. Natl. Acad. Sci. USA, 91, 11298, 10.1073/pnas.91.24.11298 Bylund, 2003, Vertebrate neurogenesis is counteracted by Sox1-3 activity, Nat. Neurosci., 6, 1162, 10.1038/nn1131 Chen, 2000, A new positive/negative selectable marker, puDeltatk, for use in embryonic stem cells, Genesis, 28, 31, 10.1002/1526-968X(200009)28:1<31::AID-GENE40>3.0.CO;2-K Driskell, 2009, Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis, Development, 136, 2815, 10.1242/dev.038620 Ellis, 2004, SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult, Dev. Neurosci., 26, 148, 10.1159/000082134 Fauquier, 2008, SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland, Proc. Natl. Acad. Sci. USA, 105, 2907, 10.1073/pnas.0707886105 Feil, 1997, Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains, Biochem. Biophys. Res. Commun., 237, 752, 10.1006/bbrc.1997.7124 Furuyama, 2011, Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine, Nat. Genet., 43, 34, 10.1038/ng.722 Galan-Caridad, 2007, Zfx controls the self-renewal of embryonic and hematopoietic stem cells, Cell, 129, 345, 10.1016/j.cell.2007.03.014 Graham, 2003, SOX2 functions to maintain neural progenitor identity, Neuron, 39, 749, 10.1016/S0896-6273(03)00497-5 Graw, 2010, Eye development, Curr. Top. Dev. Biol., 90, 343, 10.1016/S0070-2153(10)90010-0 Imamura, 2006, Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells, BMC Dev. Biol., 6, 34, 10.1186/1471-213X-6-34 Jaks, 2008, Lgr5 marks cycling, yet long-lived, hair follicle stem cells, Nat. Genet., 40, 1291, 10.1038/ng.239 Kamachi, 1998, Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction, Development, 125, 2521, 10.1242/dev.125.13.2521 Karam, 1993, Dynamics of epithelial cells in the corpus of the mouse stomach. I. Identification of proliferative cell types and pinpointing of the stem cell, Anat. Rec., 236, 259, 10.1002/ar.1092360202 Kiernan, 2005, Sox2 is required for sensory organ development in the mammalian inner ear, Nature, 434, 1031, 10.1038/nature03487 Ko, 2009, Induction of pluripotency in adult unipotent germline stem cells, Cell Stem Cell, 5, 87, 10.1016/j.stem.2009.05.025 Lefebvre, 2007, Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors, Int. J. Biochem. Cell Biol., 39, 2195, 10.1016/j.biocel.2007.05.019 Lengner, 2007, Oct4 expression is not required for mouse somatic stem cell self-renewal, Cell Stem Cell, 1, 403, 10.1016/j.stem.2007.07.020 Lombaert, 2010, Epithelial stem/progenitor cells in the embryonic mouse submandibular gland, Front. Oral. Biol., 14, 90, 10.1159/000313709 Mansukhani, 2005, Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation, J. Cell Biol., 168, 1065, 10.1083/jcb.200409182 Masui, 2007, Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells, Nat. Cell Biol., 9, 625, 10.1038/ncb1589 Montgomery, 2011, Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells, Proc. Natl. Acad. Sci. USA, 108, 179, 10.1073/pnas.1013004108 Okubo, 2006, Sox2 is required for development of taste bud sensory cells, Genes Dev., 20, 2654, 10.1101/gad.1457106 Okubo, 2009, Cell lineage mapping of taste bud cells and keratinocytes in the mouse tongue and soft palate, Stem Cells, 27, 442, 10.1634/stemcells.2008-0611 Que, 2007, Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm, Development, 134, 2521, 10.1242/dev.003855 Que, 2009, Multiple roles for Sox2 in the developing and adult mouse trachea, Development, 136, 1899, 10.1242/dev.034629 Sangiorgi, 2008, Bmi1 is expressed in vivo in intestinal stem cells, Nat. Genet., 40, 915, 10.1038/ng.165 Sangiorgi, 2009, Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis, Proc. Natl. Acad. Sci. USA, 106, 7101, 10.1073/pnas.0902508106 Shinohara, 2000, Spermatogonial stem cell enrichment by multiparameter selection of mouse testis cells, Proc. Natl. Acad. Sci. USA, 97, 8346, 10.1073/pnas.97.15.8346 Srinivas, 2001, Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus, BMC Dev. Biol., 1, 4, 10.1186/1471-213X-1-4 Suh, 2007, In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus, Cell Stem Cell, 1, 515, 10.1016/j.stem.2007.09.002 Takahashi, 2006, Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors, Cell, 126, 663, 10.1016/j.cell.2006.07.024 Taranova, 2006, SOX2 is a dose-dependent regulator of retinal neural progenitor competence, Genes Dev., 20, 1187, 10.1101/gad.1407906 Tian, 2011, A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable, Nature, 10.1038/nature10408 Yamada, 2006, In vitro transdifferentiation of mature hepatocytes into insulin-producing cells, Endocr. J., 53, 789, 10.1507/endocrj.K06-116 Yang, 1998, p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities, Mol. Cell, 2, 305, 10.1016/S1097-2765(00)80275-0 Yoshida, 2010, Stem cells in mammalian spermatogenesis, Dev. Growth Differ., 52, 311, 10.1111/j.1440-169X.2010.01174.x