Emilin1 Links TGF-β Maturation to Blood Pressure Homeostasis

Agrotis, 2005, Transforming growth factor-beta, cell signaling and cardiovascular disorders, Curr Vasc Pharmacol, 3, 55, 10.2174/1570161052773951 Annes, 2003, Making sense of latent TGFbeta activation, J. Cell Sci., 116, 217, 10.1242/jcs.00229 Beck, 2002, Extraembryonic proteases regulate Nodal signalling during gastrulation, Nat. Cell Biol., 4, 981, 10.1038/ncb890 Braghetta, 2004, Overlapping, complementary and site-specific expression pattern of genes of the EMILIN/Multimerin family, Matrix Biol., 22, 549, 10.1016/j.matbio.2003.10.005 Bressan, 1993, Emilin, a component of elastic fibers preferentially located at the elastin-microfibrils interface, J. Cell Biol., 121, 201, 10.1083/jcb.121.1.201 De Acetis, 2005, Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload, Circ. Res., 96, 1087, 10.1161/01.RES.0000168028.36081.e0 Dietz, 1991, Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene, Nature, 352, 337, 10.1038/352337a0 Eimon, 2002, Effects of heterodimerization and proteolytic processing on Derriere and Nodal activity: implications for mesoderm induction in Xenopus, Development, 129, 3089, 10.1242/dev.129.13.3089 Faury, 2003, Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency, J. Clin. Invest., 112, 1419, 10.1172/JCI19028 Inman, 2002, SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7, Mol. Pharmacol., 62, 65, 10.1124/mol.62.1.65 Izzo, 2001, Arterial stiffness: clinical relevance, measurement, and treatment, Rev. Cardiovasc. Med., 2, 29 Khanna, 2004, Concerted effect of transforming growth factor-beta, cyclin inhibitor p21, and c-myc on smooth muscle cell proliferation, Am. J. Physiol. Heart Circ. Physiol., 286, H1133, 10.1152/ajpheart.00462.2003 Koli, 2004, Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung, J. Cell Biol., 167, 123, 10.1083/jcb.200403067 Mongiat, 2000, Self-assembly and supramolecular organization of EMILIN, J. Biol. Chem., 275, 25471, 10.1074/jbc.M001426200 Mulvany, 2002, Small artery remodeling and significance in the development of hypertension, News Physiol. Sci., 17, 105 Neptune, 2003, Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome, Nat. Genet., 33, 407, 10.1038/ng1116 Piccolo, 1999, The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals, Nature, 397, 707, 10.1038/17820 Siegel, 2003, Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer, Nat. Rev. Cancer, 3, 807, 10.1038/nrc1208 Staessen, 2003, Essential hypertension, Lancet, 361, 1629, 10.1016/S0140-6736(03)13302-8 Suthanthiran, 2000, Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage, Proc. Natl. Acad. Sci. USA, 97, 3479 Ventura, 2004, JNK regulates autocrine expression of TGF-beta1, Mol. Cell, 15, 269, 10.1016/j.molcel.2004.06.007 Zanetti, 2004, EMILIN-1 deficiency induces elastogenesis and vascular cell defects, Mol. Cell. Biol., 24, 638, 10.1128/MCB.24.2.638-650.2004